Professional Documents
Culture Documents
.
20113SAN
YO-CYPS
12
5
3
3
72
9
:
.
1.
S
9119110
66441
81
151991
174
15
2.
11033
740
3.
B
C
.
1.
1985
5199131
201211 15
19914
611
119912006
22006
1.
1
19912006
1-1
4
2006
7
2006UV
UV
5
2.
1
2006
1-2
1
SDS
2
1/10
SDZ
SDS
16 201211
1980
1980
2006UV
1990
12162
2
5
1
19913
43
1
19851988
1 : 1
1989
1,25060
15201,1,1-1520
1,1,1-95
19914
19911997/98
19911992/931,2-
50601520
1,1,1-15201992/93
1997/981,2-40
5040501
101997/98
1
1997/982006
1,2-982006
3
1997
16
9
3
1
15
S
24731
1.
201211 17
19973
S1997
24681989
1984
1989
1990123
117L45L
PRTRS
20011,2-
8,300kg13001
24L1.4
1997/982000
45L
2000
2
35L
2006UV
5
18 201211
1997/98
2000
98
1-3.
1
2
12,
787
3
3,946
1,293m /hr1
4,840m3/hr 56
7,2007,656m3/hr
2,000m /hr
2224
55
20062008UV
1,8582,042m3/hr1
3
PS
2-1
4
1
PS
14
1820
14
20405
12
1
3.
1
1990
1 216 300
800
UV
UV
UV
2.
201211 19
UV
4.
2-2
2-3
PS
1996
112L1996
3.
3-1
20 201211
11
62
1
4
13
82013
254536
7
274637
121
12312
4
13
1,2-12
2.
19851,2-
71711
720
14
211
56
41
21B
C
199120061,2-
1
62 517
11515
62130
8.6
1/6
1,2-117
6.1 11
111
3.91,2-
183.3
2011126
3-2
5
33
19912011
22S
11
0.01216
50 33
SMR500951801,100
22
0.00204
SMR2,900 951,1006,400 6
531
SMR
6
640952401,400
SGTP
4,100
140 IU/L45
951,5008,800
1SGTP
60 IU/L
201211 21
.
1.
1-1
1
U.S. NTP
2B6C3F02,000
4,000 ppmF344/N0
1,0002,0004,000 ppm165
102
0/500/4922/490/50
23/4821/48
22/5024/4933/493/5016/48
40/48
U.S. NTP
2/501/50
4/505/50
22 201211
-S-GST
P450CYP
GST
CYP
GST
S-
GST
GST
1
3
2
1,2-
U.S. NTP1,2-
4
B6C3
F125250mg/kg/
F344/
N062125mg/kg/0125
250mg/kg/5103
250mg/kg/
U.S. NTP
1,2-
F344/DuCrj1,2-
01252505001,0002,000ppm16
513
2,000ppm1,0002,000ppm
GTP
2,000ppm
080200500ppm16
5104
500ppmGTP
B6D2F1/Crlj
1,2-
603280200ppm
165104
1,2-
CYPGST
7
GST
1-2 GST
GST
GST
1
GST
3
GST
Sherratt8
GST
T1-1GST
GST T1-1
GST
1
1,2-
GST
1-3
1
4
2
1919ppm
210
39ppm
0
11
2311
3140ppm280ppm475ppm
412
250100ppm350
700ppm
42
32
2
3195411
19867113
SMR20 95
5.256
199012
11
SMR
2
SMR
412
2
1,2-
ASTALT
201211 23
1-4 IARC
IARC
2B
1,2-3
14
IARC
1
2A
2B
1,2-
1997/982006
1,2-
GST
2-2
1,2-
40ppm90ppm
2.
3.
2-1
3-1
1,2-46
54
1.7L/h
60210ppm
130360ppm1
S
19911992/931,2-
120430ppm80210ppm1992/93
1997/98100360ppm
190540ppm1997/98
20061,2-
150670ppm
GST
2001,000ppm
319911997/98
313
15, 16
4
15, 16
24 201211
3-2
2005
2.61/10, 7.85/10
753544
1/5015, 17
S1991
2006162
SMR2,900 95
1,1006,400
1,2-5
31SMR4,10095
1,5008,800
3-3
13
1,2-
199120061,2-
100670ppm
GST
1,2-
GST T1-1
GST T1-1
11,2-
1312
1991
1997/9880
540ppmGST
GST
T1-1
12
1CYP
18
1,2-
GST
1,2-
1,2-
S
1997
.
S
11,22
1,2-
.
1. .
A-2012-02
2012.
2. NTPNational Toxicology Program
.
Toxicology and carcinogenesis studies
of dichloromethane in F344/N rats and
B6C3Fi miceinhalation studies
. NTP
Technical Report 306, U.S. Dept. Health
201211 25
and Human Services, Washington, DC.
1986.
3. .
Ver 1.1, No.15, . 2004.
4. NTPNational Toxicology Program
.
Toxicology and carcinogenesis studies
of 1,2-dichloropropane in F344/N rats
and B6C3Fi micegavage studies
. NTP
Technical Report 263, U.S. Dept. Health
and Human Services, Washington, DC.
1986.
5. Umeda Y, Matsumoto M, Aiso S, et al.
Inhalation carcinogenicity and toxicity
of 1,2-dichloropropane in rats. Inhalation
Toxicology 2010;22:1116-1126.
6.
. 1,2-
,
0458. 2006.
7. .
Ver 1.1, No.39, 1,2-.
2004.
8. Sherratt PJ, Williams S, Foster J,
Kernohan N, Green T, Hayes JD. Direct
comparison of the nature of mouse and
human GST T1-1 and the implications on
dichloromethane carcinogenicity. Toxicol
Appl Pharmacol 2002;179:89-97.
9. Tomenson JA. Update of a cohort
mortality study of workers exposed to
methylene chloride employed at a plant
producing cellulose triacetate film base.
Int Arch Occup Environ Health 2011; 84:
889-897.
10. Hearne FT, Pifer JW. Mortality study of
two overlapping cohorts of photographic
film base manufacturing employees
exposed to methylene chloride. J Occup
Einviron Med 1999; 41: 1154-1169.
11. Lanes SF, Rothman KJ, Dreyer NA,
Soden KJ. Mortality update of cellulose
26 201211
2009: 278-282.
16. , . 7,
,
1999: 7-13.
17. , .
.
2006: 322-330.
18. Bolt HM, Roos PH, Their R. The
cytochrome P-450 isoenzyme CYP2E1
in the biological processing of industrial
chemicals: consequences for occupational
and environmental medicine. Int Arch
Occup Environ Health 2003; 76: 174-185
TEL 093-691-7288
s
hkumagai@health.uoeh-u.ac.jp
8101
2 2481008101
12
082101
2481
47318 2
201211 27