(Chemotheraputic Agents)

(Penicillins)
1.1 (Penicillins)
01101

Penicillin G

IPC3
Penicillin G Sodium

Penicillin G Sodium inj 3,000,000 U

Vial

1. Penicicllicum mold
2.

(streptococcus)(pneumococcus)
(meningococcus)(gonococcus)(spirochetal)

1.

10,000,000

(hyperreflexia)
2. 68 1 200,000500,000 10
300,000 8 (
3 )
3. 25,00090,000 /kg 36
300,000 1,200,000 / (
10,000,0000 )

Jarisch-Herxheimer
1.
2.
a b 0.1% 0.5ml
c Hydrocortisone 50100mgd
Aminophylline 0.250.5ge
B

 1.Tetracycline Penicillin
Penicillins Chlortetracycline
2.Penicillin MethotrexateMTX
MTX
3. Ceftazidime
Penicillin Penicillinase
CNS
15 ~ 25

01102

Retarpen
IRETA
Penicillin G Benzathine
Retarpen inj 2,400,000 IU

Vial
Biochemie Gesellscha
1.
2.

1. 240 ; 240
3
2. 120 60
4
3. 1200000 300000900000
4. 4 1 1200000
--()

1.

2.
3.
4.
5.
4
6.
B
1.
2. Cephalosporines
3.
1.( IndomethacinPhenylbutazone
Salicylas)
2

2. Penicillin

15 ~ 25

1.2 (Penicillinase-Resistant)
01201

01202

Prostaphlin
IPRO5
Oxacillin sodium
Prostaphlin inj 500mg

Vial

1. 6 250500mg 6
5001000mg
2. 50100mg 40kg

3. 25mg
4.

1.
2.

1.Tetracycline Penicillin
2.Penicillin MTX
15 ~ 25

Cloxacillin

OCLOX
Cloxacillin sodium
Cloxacillin 250mg

Cap

/
1.
2.
3.

G
1.

2.
1. 46 1 500mg, 7
2. 40 : 50100mg/kg,

penicillin
1.probeneciddisulfiram

2.
1.
6 40%
2. 250mg 1 3-7mg

15 ~ 25

1.3 (Aminopenicillin)
01301

01302

Ampicillin
OAMP5
Ampicillin
Ampicillin 500mg

Cap

Ampolin
IAMPI
Ampicillin
Ampolin inj 500mg
500
Vial

 penicillin glycopeptide
transpeptidase peptidylglycan

1.
a.>40kg 2050mg/kgq68h
b.>20kg250mg q6h<20kg, 50mg/kgq68h
2.(H.influenzae,S.pneumoniae N.menigitids )
a. 12gq6h
b. 400mg/kgq4h (H.influenzae b )
3. 150200mg/kg
4.Gonococci 3.5g 1g
probenecid tetracycline 500mg qid( erythromycin 500mg )
7
5.3.5g 1g probenecid 500mg qid 7
6. 3.5g 1g probenecid doxycycline 100mg
bid 1014
7.-()3.5g 1g probenedic tetracycline 500mg
qid 10
8.(
)12g( 50mg/kg) gentamicin 1.5mg/kg( 2mg/kg)
8 6
penicillin V 1g( 27kg 500mg)
9.2g( 50mg/kg) gentamicin 1.5mg/kg(
2mg/kg)8

1. 15
2.

1. Penicillin
2.
15 ~ 25

01303

Supercillin
OAMO2
Amoxicillin
Supercillin cap. 250mg

Cap

/ VPP101
5

01304

Supercillin Suspension
OAMOS
Amoxicillin
Supercillin Suspension 1.5mg/60ml

Suspension

8 250mg 500mg

3gm Probenecid

1.
2.
3.

Supercillin (amoxicillin) 1-2

Supercillin powder for Oral Suspention

60cc

1.4 (Broad-Spectrum Penicillin)

01401

Lilacillin

ILILA
Sulbenicillin sodium

Lilacillin inj.1gm

Vial

1. 24g 4080mgkg 24
2. 13g 180mgkg


1.
2.

3.
1.
2.
3.
15 ~ 25

1.5 Penicillin
01501

01502

Soonmelt F.C
OSOON
Amoxicillin 250mg /Clavulanic acid125mg
Soonmelt F.C Tab 375mg

Tab

YSP 4

Augmentin syrup

OAUGS5
Amoxicillin 80mg/ml & Pot. Clavulanate

11.4mg/ml
Augmentin syrup 457mg/5ml35ml/bot

Bot
Smithkline Beecham

01503

Soonmelt

IAUGM1
Amoxicillin 500mg/Clavulanic Acid 100mg.
Soonmelt For Intravenous injection

Vial

Amoxicillin Clavulanic acid
- Amoxicillin

 1. 3 1 375mg 8 25-50mg/kg
1-2ml/kg 3
2. IV 20
100ML 30
1 3 1 1.2mg 8 1
6 1 1 4
30mg1 3 6 8 1
3.

AST / ALT
1. amoxicillin/clavulanic acid

2. amoxicillin/clavulanic acid

1.
2. -lactam Cephalosporin
3. penicillins /
1. amoxicillin/clavulanic acid

2.
3. probenecid probenecid amoxicillin
amoxicillin/clavulanic acid
70%amoxicillin/clavulanic acid

1. 25
2.

01504

Subacillin

ISUBA
Ampicillin sod.1gm / Sulbactam sod. 500mg

Subacillin inj 1.5g

Vial

Sulbactam sodium
Ampicillin
8

01505

mucopeptide

( Bacteroides
Fusobacterium Clostridium difficile)Branhamella catarrhalis
1. 15g 12g 6 8 Sulbactam
4 g 12
1,500mg 115mg5
1.5 -3g 6 8
1.5g 1.0g probenecid
2. 150mg/kg/ 6 8
75 mg /kg/ 12

Sulbactam

Allopurinol allopurinol Ampicillin

Ampicillin

CSF -lactam
Ampicillin Sulbactam

1.
2.
3. 0.5 lidocaine hydrochloride anhydrous

(15-30)

Tapimycin

ITAPI
Piperacillin 2g / Tazobactam 250mg.

Tapimycin inj 2.25gm.

Vial

Piperacillin Piperacillin Piperacillin/
Tazobactam -lactamase

 30
12g/1.5g 16g/2.0g 4.5g

1. -lactam Piperacillin

2.

()
3.Tapimycin Piperacillin Tazobactam
Piperacillin 2.35 (54mg)

4.

5.Piperacillin

B
-Lactamase

1. Tobramycin (AUC)
2. Probenecid Tazobactam
3.Piperacillin Vecuronium Vecuronium
Piperacillin/Tazobactam Vecuronium

Penicillins

( diazepam barbiturates)
Piperacillin 5ml

(15-30) 24
(2~8) 48

(Cephalosporins)
2.1 (Cephalosporins)
02101

U-Save
OUSAV
Cephradine
U-Save cap 250mg

Cap
-TW
/, UL 016
10

02102

S-60
IS60
Cephradine
S-60 inj.1gm.

Vial

-LACTAMASE

1.
a 6 250mg 12 500mg
b 6 250mg 12 1mg
c 6 500mg 12 1mg
d 6 1gm
2. 2550mg/kg/ 6
3.75100mg/kg/ 6
12 4gm

4. 500mg 1gm
AMCEF 2~4 gm
4 50~100 mg/kg/day
5.AMCEF 50100mg/kg/
4gm
1.
2.

3. SGOT SGPT
4. BUN
5.
6.

1.
2.
3.
B

1. Cephalosporin
2. Furosemide Ethacrynic
3.Probenecid Cephalosporin

1. 4.0ml 1.0gm
2. 10ml 1.0gm
11

3. 10ml 1.0gm
5%M/6

(15-30)

02103

Winzolin
IWINZ
Cefazolin sod
Winzolin inj 1gm

Vial

cefazolin
(PBP)

1gm
20~40mg/kg
1.5~3gm 50mg/kg 5g
100mg/kg
1.
2.
3.

4.

5. BUNCreatinine
6.

7.

8. K Prothrombin
B
CANDIDA
9.
1. Lidocaine
Anilide
2. Pencillin Cephem Cephalosporine Cephamycin

Vitamin K
3.

12

02104

4.
5.
6.

Cephalosporin
Probenecid Cephazolin
1.
2. 2ml Lidocaine Hcl inj0.5%

48

Cefadroxil
OCEF1
Cefadroxil monohydrate
Cefadroxil 500mg

Cap

, ST. 008

1. 12g 34g
a 1gm
2gm
2gm
b 1gm
c
1gm 10
2. kg 50mg kg
75~100mg

1.

2.
3. Creatinine
4.
5.

Cphalosporin
13

 Cephalosporin Aminoglycoside

(15-30)

02105

02106

Keflex
OCEP5
Cephalexin
Keflex 500mg

Cap

/, S/416

Ulex Susp

OULEX
Cephalexin

Ulex For Oral Susp 25mg/ml.(60ml./Bot)

Bot

methicillin

1. 2550mg/kg
2. 14gm 6 250mg
6 500mg1gm
3. 60ml

vitK vitB
1. Penicillin

2.
3.
B
Cephalosporin
1..
2. 14

14

2.2 (Cephalosporins)
02201

Cefaclor
OCEFA
Cefaclor
Cefaclor 250mg

Cap

/, G3213

Pseudomonas
Methicillin

...
1. 250mg 10
250mg

3gm 1gm Probenecid

4gm
2. kg 20mg 8
kg 20mg

1gm

1.
2.
3.

(15-30)

15

02202

Cefuroxime

ICEFU

Cefuroxime sod

Cefuroxime 750mg

Vial

GG
-LACTAMASE

1. 8 750mg 8 1.5gm
36gm
2. 30100gm/kg 34
3. 1.5gm 750mg

1. penicillin
2.
3.
Benedict's Fehling'sClinitest
4.
5.
6.
7.

Cphalosporin
Cephalosporin Aminoglycoside

1.Cefuroxime 250mg 1ml 750mg

3ml
2.Cefuroxime 250mg 2ml 750mg
6ml
.

16

2.3 (Cephalosporins)
02301

Flumarin

IFLUM

Flomoxef Sod

Flumarin inj 500mg

Vial

Oxacephem G(+) G(-)
1.()
Methicillin (MRSA)
Cephem
2. Cephem

( ) peptostreptococcus Branhamella
catarrhalisKlebsiella Proteus Influenzae Bacteroides

1 1~2gm 2 1 60~80mg/kg 3~4

1
150mg/kg 3~4

02302

Loforan

ILOFO
Cefotaxime

Loforan inj 1gm

Vial

1. 1gm 2gm 68
12gm 30
90 1g
2. 50100mg/kg 612
150200mg/kg
3. 1gm 23 612

4. 50mg/kg
5.

6. 3

17

 1. 35
2.
3. 30

1. Aminoglycoside
2. Coombs
Enzymatic Method
Cphalosporin
Cephalosporin Aminoglycoside

02303

02304

Unizid
IUNIZ
Ceftazidime
Unizid inj 2gm

Vial

-LACTAMASE

1. 16g 2 3
2.02 2560mg/kg
3.2 30100mg/kg 2 3

1.

2.Benedict's Fehling's Clinitest

3.Creatinine
4. COOMBS

cephalosporin

Sintrix

ISINT
Ceftriaxone sod

Sintrix 1g inj

Vial

18

02305

Tricef

ITRIC
Ceftriaxone sod

Tricef inj 1gm

Vial

1. 12g 50mg/kg 50mg/kg

30
4g
2. 2050mg/kg
3. 2080mg/kg
SGPTSGOTBUN

1.

2.Ceftriaxone cephalosporin Albumin Bilirubin

Hyperbilirubinemia
3.
4. Epinephrine Glucocorticoid

Penicillin & Cephalosporin
Aminoglycoside
1. 2g
2.

2.4
02401

Mepem

IMEPE
Meropenem

Mepem inj.250mg.

Vial

Dainippon-Japan
1.

non-glucose-fermenting G(-)-Pseudomonaseruginosa
19

lactamase
-1(DHP-1) DHP-1
2.(PBPs)
peptideglycan
Meropenem
Mepem ( Staphylococcus spp,Streptoccus
spp, Enterococcus spp, Klebsiella spp, Enterobacterspp, Serratia spp, Proteus
spp, Pseudomonas spp, Haemophilusinfluenzea and Bacteroides spp)

1.
14
2. 1 0.5~1g Meropenem() 2~3 30
2g()
1.

2.
3.
4.PIE syndrome X

5.
1.

2.
3. 7 GOTGPT

4.
5.
carbapenempenicillin cephem
Sodium Valproate( Valproic Acid
)
0.25g() 0.5g() 100ml

2.5 Cephalosporins
02501

Tienam

ITIEN500
Imipemen/Cilastatin

Tienam inj 500mg.

Bot

20


G+G-
1. Imipenem
2.

8 250mg 8
500mg 8 5001000mg

1.

2.

(Tetracyclines)
3.1 (Tetracyclines)
03101

Tetracycline

OTETR
Tetracycline Hcl

Tetracycline 250mg

Cap

/, 184

Oxytetracycline Chlortetracycline

1gm
2050mgkg

1. 13
2.
3.
4.
5.
6.
21

03102

7.
8.
D

15 ~ 25

Doxymycin

ODOXY
Doxycycline

Doxymycin 100mg

Cap

/, DEC

2 1 2
12

l.
2.
D
Doxycycline/Tetracycline products
1.Barbituratescarbamazepinephenytoin doxycycline

2. Doxycycline
3.
~90%18~22hr
0.9~1.8 L/kg82~93%

(15-30)

22

03103

Tygacil
ITYGA
Tigecycline
Tygacil 50mg/vial Lyophilized Powder

Vial

Tigecycline glycylcycline
tRNA 30S tigecycline
30S A site tRNA

Tigecycline

100mg 50mg 12 5~14

18

D
Tigecycline warfarin

15 ~ 25

( Macrolides)
4.1 ( Macrolides)
04101

Ilosone
OILO
Erythromycin Estolate
Erymycin (Ilosone) 250mg

Cap

/
t-RNA

1. 14gm 250-500mg 6-8

2. 30-50 mg/kg/ 6
3. 4g -

23

1.
2.
B

1.Erythromycin bromocriptine

2.Erythromycin cyclosporine cyclosporine

3.Theophylline erythromycin

15 ~ 25

04103

Erythromycin
EERYO
Erythromycin
Erythromycin

TUBE

G+

(N.gonococcus)(C.trachomatis)
1

1.

2.
1. 15 ~ 25
2.4

24

04104

04105

04106

Klaricid
OKLAR1
Clarithromycin
Klaricid Film-coated Tablets 500mg

Tab
Abbott

Omeprazole

1. 250mg~500mg
250mg7~10
2.500mg Omeprazole
40mg 14

PimozideAstemizoleCisapride Terfenadine
C
macrolide
Theophylline Carbamazepine Clarithromycin

15 ~ 25

Zithromax
OZITH
Azithromycin
Zithromax 250mg

Tab

, ZIM 250

Zithromax Susp
OZITS
Azithromycin 200mg/5ml
Zithromax Powder for oral Susp

Bot

()

1. (Chlamydia trachomatis)
25

1 500mg
24 250mg 4 15
3 500mg 5 500mg
25 250mg
2. 30mg/kg 10mg/kg 3 10mg/kg
25 5mg/kg
1.
(/)
2.
3.
1. 1 2
2.
3. warfarin
4. 2
5.
6.
7.

B
azithromycinerythromycinmacrolide
1. 50%
2. erythromycintroleandomycin dirithromycin
theophylline
theophyllines
50%
1 2
30

26

 (Aminoglycosides)
5.1 (Aminoglycosides)
05101

05102

Gentamycin Vial
IGM1
Gentamycin Sulfate
Gentamycin inj. 80mg/2ml

Vial

Gentamycin Amp

IGM2
Gentamycin Sulfate

Gentamycin inj. 80mg/2ml

Amp

Aminoglycoside

1.

2. Pseudomonase CNS
1. 3mg/kg 3 (q8h)
5mg/kg 3mg/kg 710
a.22.5mg/kg q8hb.()2.5mg/kg q8H
c.()2.5mg/kg q12h
2.() ampicillin12g
gentamicin 1.5mg/kg( 80mg)8
2 6 penicillin V 1g q6h
3.() 0.51
ampicillin 2g gentamicin 1.5mg/kg( 80mg)8
2 3,0000units/kg aqueous penicillin G
50mg/kg ampicillin 2mg/kg gentamicin
4.
a.()= x8
2mg/dl 16 b.=/
60kg 60mg q8h 2mg/dl
30mg q8h
5. 0.52 23
6. 48mg qd(>3
)12mg
--
27

05103

-
1. 3~5

2.
2mcg/ml~12mcg/ml
3. I/O Gentamicin
I/O
4. Gentamycin Fanconilike

5.

Gentamycin Aminoglycoside
Aminoglycoside
1.Aminoglycoside acetylcholine
acetylcholine

2.Loop Diurtic Aminoglycoside

15 ~ 25

Gentamycin eye drop

EGEND
Gentamycin Sulfate

Gentamicin eye drop 5ml

Bot

Gentamicin Amino-glycoside Antibiotics

:12 1 34

D
Gentamicin
15 ~ 25
28

05104

05105

Neomycin
ONEOM
Neomycin Sulfate
Neomycin 250mg

Cap

, GCPC 1403

1. 8
2. 16 13
-

aminoglycosides
(15-30)

Neomycin Oint

ENEOM
Neomycin
Neomycin Oint

Tube

05106

Bacitracin Neomycin
EBACI
Neomycin sulfate/Bacitracin zinc
Bacitracin Neomycin 30g

Tube

2~4

29

05107

05108

Sisogen
ISISO
Sisomicin Sulfate
Sisogen inj 100mg/2ml

Vial

1. 100mg 150mg

2. 5%

Sisomicin Aminogly cosides

1. Dextran sodium Alginate
2.

Tobramycin
ITOBR
Tobramycin Sulfate
Tobramycin inj 40mg/ml 2ml

Vial

DNA DNA

1. 3mgkg
2. 5mgkg 34
3. 67.5mgkg 34
4. 4mgkg
5. 1mgkg

30

SGOT

710 10

05109

Unikin

IUNIK
Amikacin
Unikin inj 250mg.

Vial

kanamycin

1. 8 5 12
7.5 () 20 7 10
2. 12 250
3. 1.5 10
4. 10mg/kg 12 7.5mg/kg
5. 4 6 5 7.5
(1 1.5 )

1.
2.
3. 10
D

Amikacin Aminoglycosides

(15-30)25 3 2-8 7
25 1 2-8 3

(Polypeptides)
31

6.1 (Polypeptides)
06101

Targocid
ITARG
Teicoplanin
Targocid inj 200mg

Vial
Gruppo Lepettt S.P.A. -ITALY
Methicillin

1.
400mg IM
IV 200mg 12
IV 400mgIV IM400mg
2.

1.
2. Vancomycin Vancomycin
teicoplanin
3.
teicoplanin
4. / Aminoglycosides, Colistin,
Amphotericin B, Cyclosporin, Cisplatin, Furosemide Ethacrynic acid

5. Targocid

teicoplanin
Teicoplanin
CSF
( 0.3
3 ) 70100
0.6l/KG
9095%teicoplanin

97% teicoplanin
4 12 12
32

 ( Quinolones)
7.1
07101

Urintestin
ONEGA
Nalidixic acid(Negacide)
Urintestin 500mg

tab

, 750
pH
DNA RNA
proteus , E.coli, Enterobacter Klebsiella

1. 1 4 2 1g 2
2.1 2g 1
3. 1 55mg 4 2
1 33mg/kg

()()

()
1. Oxolinic Acid
2. BishydroxycoumarinWarfarin
3. Ketogenic Steroids 17-Keto
4. 12
5. ClinistixTest-Tape

6.

7.

Nalidixic acid warfarin

warfarin warfarin
15 ~ 25

33

7.2
07201

07202

Cixa
ICIXA
Ciprofloxacin 100mg
Cixa 100mg/50ml.inj

Bot

Cinolone

ICINO

Ciprofloxacin 200mg

Cinolone 200mg/100ml inj

Bot

Quinolone DNA gyrase

2 100200mg 3060 100mg

()
1. warfarin quinolones
( prothrombin timesINR )
warfarin
2.

Quinolone

1.Ciprofloxacin methadone
quinolones methadone (CYP1A2 and 3A4)
2. warfarin warfarin PT INR

1~2 20%
3.5~4.5 30~50%
15 ~ 25

34

07203

Sinflo FC

OSINF
Ofloxacin

Sinflo FC Tab 200mg

Tab

07204

Tarivid

ETARI
Ofloxacin

Tarivid OTIC

Bot

Daiichi-Japan
Quinolone
pyridone carboxylic acid

1.

2.

1. 300600mg 23

2. 2 6 10 10
10 1~12 5 0.25 mL0.75 mg
ofloxacin
10 0.5 mL1.5 mg ofloxacin

S-GOTS-GPTALPr-GTPTotal Bilirubin

BUNCreatinine

1.
2.
3.
4.HemoglobinHematocrit

5.

6.

35


1.
(Cmax )(AUC)
100600mg (T) 35

2.

0.3 %
602 mg/gotorrhea
389-2850 mg/g 0.3 %10
0.5 mL1.5 mg ofloxacin
4.1 5.4 ng/mL
10 ng/mL

28

7.3
07301

Cravit
OCRA5
Levofloxacin
Cravit 500mg FC Tab

Tab

DNA Gyrase Ofloxacin 2

MIC MBC
MIC

1. Clcr>50ml/min 500 1
()250 1 500
1
2.(Clcr>50ml/min)Creatinine clearance 24
250 250mg 24 500 500
12 500 500
1.
()
(Lyell )(Stevens-Jonson )
()(
36

2.;
BUNCreatinine ; GOTGPTALPr-GTP

1.
2.
3. levofloxacin
4.
:D-
Ofloxacin
1.Quinolone class Ia class III
QTc torsades de pointes
cisapridephenothiazine

2.quinolones warfarin PT INR

15 ~ 25

(Sulfonamides )
8.1 (Sulfonamides )
08101

Kingmin
ESINO
Sulfamethoxazole
Kingmin Eye Drops 4% 10ml

Bot

sulfsoxazole
2

1 3

1.
2. 5~10

37

08102

08103

Bacide
OBAKT
Sulfamethoxazole 400mg/Trimethoprim 80mg
Bacide (Baktar)

Tab

, 705

LYELL GOTGPT
BUN PIE

1.

2.

3. Bilirubin

1. methotrexate
methotrexate

2.warfarin wafarin

15 ~ 25

Spasmo-Euvernil
OSPAE
Sulfacarbamide 500mg / Phenazopyridine 50mg

Spasmo-Euvernil
-
Tab

10

38


1.
2.
3.

08104

08105

Sulfasil Cream
ESULF1
Siver Sulfadiazine
Sulfasil Cream 1% 25gm

Tube

Sulfasil Cream
ESULF
Siver Sulfadiazine
Sulfasil Cream 1% (1bot=200gm)

Bot

Enzyme Blocker DNARNA

Siver Sulfadiazine

Deformation

2 3
12 1/16

Sulfadiazine
1.
2.

3.

glucose 6-phosphate
1.Silver Sulfadiazine
2. Silver Sulfadiazine
Siver Sulfadiazine
Amorphous colloids 100%
15 ~ 25

39

 (Miscellaneous Antibiotics )
9.1
09101

09102

Clindamycin
OCLIN
Clindamycin
Clindamycin cap150mg

Cap

/, SK G-1162

Clindamycin inj

ICLIN
Clindamycin Phosphate inj 300mg/2ml.

Clindamycin inj 300mg/2ml

Amp

50s

1. 2400
2700mg 24 12001800mg
600mg
2. 2024mg/kg
3. 1520mg/kg

-
( IV )
1.
2. 1060
3.
4.
B
Clindamycin Lincomycin

nondepolarizing muscle relaxants

40

09103

Vanco

IVANO
Vancomycin

Vanco inj 500mg

Vial

[]
()
Penicillin,Cephalosporins
clostridium
1. 6 500mg 12 1g1 44mg/kg

2. 10m
100~200ml 6 1 30
-
1.
2.
C

1. aminoglycosidescephaloridinepolymyxin Bcolistinfurosemide
ethacrynic acid
2. tertacyclineserythromycins Vancomycin

15 ~ 25

09104

Fucidin
OFUCI
Fusidate
Fucidin 250mg

Tab
Laboratoires LEO S.A.
, 121
Fusidic acid
Fusidic acid
fusidic acid

41

1 3 1 500mg50mg/kg 3

1. ,
Lincomycin rifampicin ,
2.
D

1. Coumarin derivatives
2. HMG-CoA stain
rhabdomyolysis
3. HIV Ritonavir Saquinavir

4. Cyclosporin Cyclosporin
Fucidin
Fucidin Suspension

Fucidin
0.03-0.16 mcg/ml
Fusidic acid
()
(15-25)

(Antituberculosis Agents)
10.1
10101

Ebutol
OEMB
Ethambutol
E M B , Ebutol 400mg

Tab

42


1.
2.

3.

10102

Duracrin

OINAH
Isoniazid

Duracrin 100mg

Tab

, GCPC

INH
B6
1.

2.a
b

Corticosteroits
1.- 5mg/kg(1 300mg)-1
10~20mg/kg(1 300mg)
2.-1 300mg)-1 10mg/kg
()
()
1. B6(1 10100mg) Isoniazid

2. 6 2
3.
4.
5.
6.

1. carbamazepine
43

Carbamazepine isoniazid
2. hydantoins

12 16
50%
acetylate hydrolyzed 2~3
90% 6

10103

Pyrazinamide
OPZA
Pyrazinamide
P.Z.A. Tab 500mg(Pyrazinamide )"Y.S.

Tab

, GCPC-1614

34 1.52gm INAH0.30.4gm
13

1.
2.
3.
4.

1. Probenecid Sulfinpyrazone
2. cyclosporine cyclosporine
2 910
(70%)
(15-25)

44

10104

10105

Rifampin 300mg
ORIF3
Rifampicin
Rifampin 300mg

Cap

Rifampin 450mg
ORIF450
Rifampicin
Rifampin 450mg

Cap

/, 476

Rifamyicin

450600mg
450mg

S-GOTS-GPT

2.
3.
4.
5.
6.

1.Rifampin cyclosporine
2.Rifamycins warfarin
3.Rifamycins theophylline
theophylline
4. Ethambutol
5. bumarin Digitalis
45

Isoniazid Streptomycin

150mg 2
8
24 3 8090%
(
)

10.2
10201

Rifinah 150mg
ORIFI1
RIF 150mg+INAH 100mg
Rifinah 150mg
150

Tab
Gruppo Lepettt S.P.A

10202

Rifinah 300mg

ORIFI
RIF 300mg+INAH 150mg

Rifinah 300mg
300
Tab

Gruppo Lepettt S.P.A

1.RIF DNA-dependentRNA polymerase

2.INH
INH
B6

RIF 600mgINAH 300mg

1.
2. S-GOTS-GPT 2~4

3. Vitamin B6
D

46



1.Rifampin Corticosteroids

2.PAS rifampin
3.PAS isoniazid PAS INH acetylation
4.INAH

5.Rifampin isoniazid
(15-25)

10203

Rifater
ORIFA
Rifampin 120mg+INAH 80mg +PZA 250mg
Rifater

Tab
Gruppo Lepettt S.P.A

1.RIF DNA-dependentRNA polymerase

2.INH INH
B6
3.PZA PH

1.-1 600mg 5 1 1020mg/kg

2.Meningococcal -1 600mg 4 5 1
10~20mg/kg 3

1.

2. S-GOTS-GPT 2~4

3. Vitamin B6
D

rifamycinisoniazidpyrazinamide
1.Rifampin
Corticosteroids
2.PAS rifampin
47

3.PAS isoniazid PAS INAH acetylation

4.INAH

5.Rifampin isoniazid
6.Pyrazinamide probenecid sulfinpyrazone
(15-25)

(Anthelmintics)
11.1
11101

Conquer
OVER
Mebendazole
Conquer 100mg.

Tab

, YY SSS
ATP

1.
1 100mg 1 3 2~3
3 2

2.100mg

1.
2.
3.
4.

5.

6.
7.

Phenytoin Carbamazepine mebendazole
48

mebendazole
valproic acid(depakine)mebendazole

5~10%~80%2.8~9.0hr
1.0~1.2 L/kg95%

(15-30)

(Antitrichomonal Agents and Anticandidal Agents)
12.1
12101

Frotin

OFROT
Metronidazole
Frotin 250mg

tab

12102

Medazole

IMETR
Metronidazole

Medazole inj 500mg.

bot

12103

Sutrol gel-vaginal
ESUTR
Metronidazole 7.5mg/g vaginal gel
Sutrol gel-vaginal 25g

Tube

DNA

Metronidazole
49

 1. 250mg 2 10
15mgkg 7
2. l5mg
7.5mg 1g 6 7
4g
30~60
3.
3 9
1.

2.

1.
2.
3.
4.()
5. 46

1. Metronidazole Nitroimidazole
2.
3.
1. Acetaldehyde
Disulfiram
2. warfarin

60-80%
100%6~9hr0.6~1.1 L/kg0~20%
6-12 8

25

50

12104

Clomazole
ECLOM
Clotrimazole 500mg
Clomazole Vaginal Tab

EA

, P-1005

1.

2.
46

15

clotrimazole tacrolimus
tacrolimus (CYP3A4)tacrolimus clotrimazole AUC
2
25

12.2
12201

Talsutin
ETALS
Tetracycline/ Amphotericin B
Talsutin Vaginal

EA

SQUIBB

12 2
2
51


1.

2.

3.

4.
5.


25

(Scabicides)
13.1
13101

Jaline

EBB
Benzyl Benzoate

Jaline 150ml

Bot

1. 10 25%
24
2.
3. 10ml
10ml
1.
2.
3.
25

13102

Scabi
ESCAB
G-benzene hexachloride
Scabi Cream 10gm

Tube
52


Lindane(Gamma-BHC)

1.
812 . 30g
1 2
2. 35
1.
2.12

3.
1.
2.
3.
4. 24
C

-BHC

15 ~ 25

13103

Scalphen

ESCAL
Mesulphen
Scalphen Ointment

Tube

1~2

1.

2.

53

13104

13105

Ulex
EULEX
Cortamiton
Ulex Cream 10g

Tube

Hydrocortisone

()
C

1.
2.
3.

Biofur

EBIOF
Sulfur Precipitated

Biofur Acne Lotion 50mg/g 30 ml

Bot

54

(Antifungal Agents)
14.1
14101

14102

Mycostatin
ONYST
Nystatin
Mycostatin 50 U

Tab

580

Mycostatin Syrup

OMYCS
Nystatin

Mycostatin Syrup 10 U/ml

Bot

14103

Nystatin
EMYCO
Mycostatin Vaginal 10 U
Nystatin

EA

7117
Nystatin Polyene

1.
2.
3.

1. 1~2
55

14104

48
2. 1ml
100000
48
3. 1-2 2

36
1.
2.
1.1 150 1
2.

Diflucan

ODIFL
Fluconazole
Diflucan 150mg.

14105

Diflucan inj

cap

, FLU-150
IDIFL
Fluconazole
Diflucan inj 100mg/50ml

Vial

triazole sterol

CSF

1.200400mg
a. 400mg 200400mg
68
b. 100mg AIDS
c. 400mg 200mg 400mg
d. 50mg 714
56

14106

e. 50mg 14
f.
50mg 1430
100mg 150mg
g. 50mg
2.

12mg/kg
36m/kg
3.

1. 200mg/100ml 15mmol

2.

1. triazole
2.
1. HMG-CoA reductase lovastatinatorvastatinsimvastatin

2.warfarin azole
warfarin
Fluconazole IV
() IV 90
0.5~1.5 30
4~5 90% 11~12

80% 80%

50%

Icomein

OICOM
Itraconazole
Icomein 100mg

Cap

, ICOMEIN / EVEREST
triazole
57

14107

1. 200mg
200mg
2. 200mg
3. 100mg 15
4. 100mg 15
15
5. 100mg 15
6. 200mg 21

1.
2.
3.
C

-
15 ~ 25

Grisen
OGRIS
Griseofulvin
Grisen 500mg.

Tab

, 728
1.

2.

1. 500mg

2. kg 10mg

12
3.

58

 1.
4-6
2. phenobarbital phenobarbital
3.
4.
5.

Penicillin
phenobarbital primidone griseofulvin griseofulvin
griseofulvin

14108

Lamisil

OLAMI
Terbinafine

Lamisil tab 250mg

Tab

Novartis
, S/T
Allylamine

Squalene Squalene epoxidase

24 6 4 125mg
250mg 26 24

()()

1. 2

2.

3.( 50 /
3000 /)
4.

terbinafine
terbinafine
1.terbinafine tricyclic antidepressants nortriptyline
59

 nortriptyline
2. rifampicin
P450 cimetidine
250 2 0.97g/ml
3
3
6
3

15 ~ 25

14109

Jia Mei

EJIAM
Naftifine

Jia Mei Cream 10g

Tube

ergosterol

Naftifine

(Antivirals agents)
15.1
15101

Zovirax
EZOV2
Acyclovir
Zovirax cream 2gm

Tube

60

15102

15103

Zovirax oph
EZOV3
Acyclovir
Zovirax ophthalmic oint oph 3% 4.5gm

Tube

thymidine kinase acyclovir

monophosphate diphosphate triphosphate
triphosphate DNA polymerase
DNA DNA polymerase
1.

2.
1. 5
2. 1 5 4
3
-(stinging)
Zovirax IV
-

1. finger cot
2.
3.

4.
B

acyclovir propylene glycol

1. Probenecid
2. Zidovudine
3.acyclovir theophyllines

30

Valtrex
OVALT
Valaciclovir Hcl
Valtrex tab 500mg

Tab

61

 , VALTREX 500
Valaciclovir aciclovir valine Aciclovir
DNA DNA DNA

1. 1000mg

2.

valaciclovir(1 8g)

valacicloviraciclovir
1.Cimetidine probenecid aciclovir aciclovir
AUC
2. aciclovir
15 ~ 25

15.2
15201

15202

Amantadine

DC amanda

OAMAN
Amantadine
Amantadine 100mg

Cap

Amanda
OAMAN1
Amantadine
Amanda 100mg

Tab

, WD
1.(corpus striatum)
Dopamine dopamine
Dopamine
62

15202

2.

A
1.100mg 12 400mg
100mg 2 300mg
2.(influenza)100mg 2
19 24mg// 150mg/

()
1.

2. 7

amantadine anticholinergic

Tamiflu
OTAMI
Oseltamivir
Tamiflu 75mg

Cap

/ , ROCHE,
75mg
1.
2.(neuraminidase)

3.

(A B )
1. 2 1 75mgCrC1 1030mL/ min
1 5
2.a.2 1 ()7
1 6 CrCl 10
30mL/min 1 75mgb.
48

63

FDA

oseltamivir phosphate
probenecid oseltamivir carboxylate
oseltamivir
24 40
2 1.3 24
23
60%

15.3 B I
15301

Zeffix
OZEFF
Lamivudine 100mg
Zeffix 100mg

tab

, GX CG5
B
triphosphate(TP) lamivudine-TP
B (polymerase)
DNA DNA Lamivudine-TP
(deoxynucleotide)
B B
1. B B
2.
3.4.
1. Lamivudine
2. HIV zidovudine
a. 12 50 150 mg<50
2 mg/kg
b. 3 12 4 mg/kg
150 mg
3. B 16 100 mg

1. B 4
ALT
2.Lamivudine AUC
64

50ml/min
3. HIV 37CTM(lamivudine)
CombivrTM(lamivudine/zidovudine) HIV
150 2
C

trimethoprim-sulfamethoxazole (TMP-SMX) lamivudine

triphosphate 1719
1
8g/ml

15.4 C
15401

Rebetol

OREBE
Ribavirin
Rebetol 200mg.

Cap


1.Ribavirin RSV
RNA DNA Mrna
Guanosine methylation

2.Ribavirin HCV HCV

Peginterferon -Interferon 1. -Interferon

C 2. C
1000-1200mg

1.Rebetol 18
2.
3.Ribavirin interferon alfa-2b
4.
5. 6
6.
X

65

 1. Ribavrin Rebetol interferon alfa-2bIntron A

-
2.
3.
ribavirin warfarin warfarin
Ribavirin C 6 12
6 (HCV-RNA)
C interferon alfa-2bRibavirin
interferon alfa-2b interferon alfa-2b 10
HCV-RNA
ALT

(Antineoplastic Agents)
16.1 (Alkylating Agents)
16101

Endoxan

OENDO
Cyclophosphamide

* Endoxan 50mg

Tab
Baxter-Germany

16102

Endoxan inj

IENDO
Cyclophosphamide
* Endoxan inj 200mg

vial
Baxter-Germany
oxazaphosphamide
4-hydroxycyclophosphamide
aldophosphamide DNA
DNA
G2

1. 50200mg25mg/kg 50150mg/
66

2
2.4050mg/kg 25 10
15mg/kg 710 1 35mg/kg 2 1.5
3mg/kg28mg/kg 60250mg/ 6
6 1015mg/kg 710 1 30mg/kg 34
1
3.

1.
2.

3.
4. X
Cytatoxic agent Endoxan
Endoxan

-
D

1. cylcophosphamide
2.(active infection)(
cytotoxic agent )
1.
2. phenobarbital

16.2 (Anti-metabolites)
16201

Fluorouracil

IFLUO
Fluorouracil

* Fluorouracil inj 500mg/10ml

vial
Pharmachemie B.V
Fluorouracil
Fluorouracil
5-fluoro-2'-deoxyuridine-5'-phosphate thymidylate synthetase
deoxyuridylic thymidylic DNA
67

fluorouracil RNA RNA

uracil phosphatase RNA
DNA RNA fluorouracil

1.
2.Bowen

1. 0.250.5g l 5~10g
1~2 2
2. 0.5~1g l0~20mg/kg 5% 500~1000ml
l 815g

( 2-3
3-4 )

1.
2.
3.

4. 23
5. 12
D

Fluorouracil
1. fluorouracil
2.
3.
4.

Fluorouracil/Leucovorin fluorouracil
Fluorouracil//

1.5-FU
2. 0.2-0.5L/Kg10% 5-FU IV
5-FU 5-FU

3.5-FU
-fluoro--alanine
4. 15%( 90%
)60-90% 5-FU
5-FU 5-20
5.(15%)5-FU

68

 5-FU

16202

Methotrexate

OMET2
Methotrexate

* MTX(Methotrexate)2.5mg

tab
Heumann(Wyeth)-Germany
, 2.5

16203

Abitrexate

IABIT
Methotrexate

* Abitrexate inj 50mg/2ml

vial
Pharmachemie B.V.
methotrexate DNA
RNAmethotrexate s

1. 30mg/m2 5 2

2.1 1 1025mg 1 50mg

3. methotrexate100mg/10g/, 6~24 1~3
1 70mg/m2 calcium folinate

4. 5
-

-
1. Cytarabine methotreate
(anaphylactoid reactions)

2.

3.
4. 1-2

69

5. Methotrexate
6.
X

Calcium leucovorin methotrexate methotrexate

12 IV 75mg calcium leucovoorin 6 IM 12mg
4 methotrexate 6 IM 12 4
Calcium leucovorin methotrexate
1

16.3
16301

Pharmorubicin
IPHAR
Epirubicine
Pharmorubicin inj 50mg/1vial

vial
Pharmacia Italia S.P
DNA

1.Pharmorubicin 60~90mg/
2. I.V. 3~5 21

3.
60~75mg/
4. 23

5.a.bilirubin1.4~3mg/100ml
BS Prevention9~15% 50%b.
bilirubin>3mg/100ml BS Prevention>15% 75%
6.

1.
2.
3. Pharmorubicin
70

4. Cytotoxic Pharmorubicin

5. 1~2
6.
7 550mg/m2
8.mediastinal/pericardial
area 400450mg/m2
9.

1.
2.
Anthracycline

Doxorubicin

16.4
16401

Leuplin Depot
ILEUP
Leuprorelin Acetate
Leuplin Depot inj 3.75mg

vial

Leuplin Depot (LH-RH)

LH-RH Leuprorelin acetate)
4 4 Leuprorelin
-
estradiol
testosterone

1. 4 3.75mg 1-5
6
71

16402

2.
4 1.88-3.75mg
1-5
3. 4 3.75mg
4. 4 leuprorelin acetate
30mcg/kg 90mcg/kg

pleuralrub
1.

2.
LH-RH
3./

1. LH-RH
2.
3.

Tamoxifen
OTAMO
Tamoxifen
Tamoxifen 10mg.

Tab
Pharmachemie B.V

10mg 2 20mg 2
1.

2.

1.
2.
3.
4.
D

72

16.5
16501

BCG
IBCG
B.C.G. Vaccine Freeze-Dried
BCG Immunothregpeutic Immucyst
BCG
Bot

cytokines
TA
T1
1.BCG 15
60
5%
15
2. BCG BCG 6
6 1 1 3
3 1 6 1 6
4.(CIS) 7
14 3 6
1 (bladder irritability)
(granulomatous prostatitis)
2. 2~4 24~72

3. 13 (fever)

4.
1.
2.
""
3.
4.

5.

6. isoniazid 300mg
73

 BCG
BCG Isoniazid
7. BCG 2
isoniazid 300 mg Rifampicin 600mg/ ethambutol 120mg/
cycloserine 250500mg

1. BCG

2.//
BCG
3.
4. BCG

1. 2 ~ 8 ()
2 2hrs

16502

Pegasys

IPEGA
Peginterferon-Alfa-2a

Pegasys Prefilled 180mcg/0.5ml/syringe

Syrg

-2a

1. B HBeAg HBeAg
/anti-HBe
2. ribavirin C

1. B HBeAg HBeAg B
180mcg 48
2. C ribavirin
180mcg 48
ribavirin

ribavirin
1.
2. 50,000/mm3
25,000/mm3
74

3. (CBC)
4.
5.
6.
7.
8.

9.
10.

11.
12.

1. PEGpolyethyleneglycol

2.
3. 3
Pegasys P450 1A2 theophylline AUC
1. 72-96
180 3-6 24
80% 84% -2a

2.Vss 6-14
Pegasys

3. Pegasys 100
/ -2a 100
10% peginterferon -2a

4. 60
80 50-130
2-8

16.6
16601

Campto

ICAMP

Irinotecan

* Campto conc soln I.V infusion 100mg/5ml

vial

75

 1. (Camptothecin) DNA
topoisomerase I carboxylesterase
SN-38SN-38 Irinotecan DNA topoisomerase I
DNA DNA
S
2. acetylcholinesterase
1.
2. 5-FU Folinic Acid
3. 5-FU
300350 mg/ 30 90

1.

2.
3. 86%

1.

2.
3.

4. WHO (performance status)>2

5.(
)

6. 30 90

7.(complete blood cell counts)

( 381,000 /)

1. irinotecan hydrochloride trihydrate

2.(bilirubin)>1.5
3./
4. WHO (performance status)>2
1.Dexamethasone
2.Live vaccine
3

76

16.7
16701

16702

Plaquenil
OPLAQ
Hydroxychloroquin
Plaquenil 200mg

Tab
Sanofi
, 200 HCQ
DNA RNA

1.

2.

400-600mg 200-400mg

1. 6-(glucose-6-phosphated ehydrogenase)

2. 4-aminoquinolines quinine

3.

4.
C

15 ~ 25

Eloxatin
IELOX
Oxaliplatin
* Eloxatin inj 50mg

Vial
Sanofi Aventis
77

 1. platinum oxalate 1,2-diaminocyclohexane

(DACH) platium
2. oxaliplatin (DNA)
(intra and interstrand crosslinks) DNA

3.Oxaliplatin
cisplatin

fluoropyrimidines 5-fluorouracil
Folinic acid
130mg/m2 3

250~500ml 5% 2~6

1. 3

2.
3.

4.

5. 2
6
6. 7
25%
25%

7.(<2000/mm3 <5000/mm3)

(hemogram)
8. fluoropyrimidines fluoropyrimidines

9. 5-fluorouracil5-fluorouracil 5-fluorouracil

10.
11. 4 3-4
(<1000/mm3) 3-4 (
<5000/mm3) 5-fluorouracil
25%
D

78

 oxaliplatin
5-fluorouracil

16703

Filgrastim

IFILG
Granulocyte Colony Stimulating Factor

Filgrastim inj 300mcg/0.7ml

M300
Amp
Kirin-Japan

1.
2.
3.
4.
1 5
300ug/m2 5000/mm2

2.
50ug/m2 1 100ug/m2
1
3. 1000mm2 200ug/m2 1

S-GOT,SGPT

AlpLDH Creatinine

1.
2.

3.

4.

5.

6.

79


7.
C

1.
2.

2-8

16.8
16801

Ufur

OUFUR
Tegafur 100mg.& Uracil 224mg
* Ufur

cap

, UFUR
tegafur 14 uracil tegafur 5-FU

cisplatin

tegafur 500-800 mg/day 300-350 mg/m2/day

2~3

1.`

2.()

()
3.
4.
5.
6.
X

1.
2. sorivudine
80

 1.uracil soriyudine

2. phenytoin phenytoin phenytoin

3.()

Tegafur 7.861.19
5-FU 13.14.2 Uracil
1.500.76
35.319.2

(Drugs Acting On the Central Nerve System)

( Nonbarbiturate Sedative- Hypnotics)

17.1 Benzodiazepepine(BDZ)-
17101

Dormicum

IDORM
Midazolam
Dormicum inj.5mg/ml.

amp

17101

Midazolam

IMIDA
Midazolam
Midazo inj.15mg/3ml

amp

7.5~15mg 4

81


1.
2. 6 12
3.
4.
Benzodiazepine
1.

2.
15 ~ 25

17103

Eszo

OESZO
Estazolam

Eszo 2mg

Tab

, ST

1 1~4mg
1.

2.

3.
1.
2.

3.

1.MAO Inhibitor Phenothiazine

2.
82


15 ~ 25

17104

Modipanol

OMODI
Flunitrazepam
()Modipanol 2mg.

Tab

, F 2

0.5~1mg
2mg

4mg

6~8

flunitrazepam

flunitrazepam

flunitrazepam
()
Benzodiazepines

1.

2.(/
)

3.
4.( cytochrome P450)
83

benzodiazepines benzodiazepines
5.

15 ~ 25

17.2 -
17201

Insopin

OINSO
Zopiclone
Insopin 7.5mg.

Tab
Doupharma-Malysia
, 8/61 DUO
Non-benzodiazepine benzodiazepine
(benzodiazepine receptor complex) gamma-aminobutyric
acid (GABA) 1 GABA
GABAA- chloride ionophore protein complex
Cl- Cl-
(threshold)

1
1

1.
2.
3.

4.
5.
6.
7.

Zopiclone 15
1.Curare-Like Compounds

84

2. Neuroleptics
3. Benzodiazepines
15 ~ 25

17202

Zolnox FC

OZOLN
Zolpidem
Zolnox FC Tab 10mg

Tab

, ZOLNOX
benzodiazepine
GABA
GABA GABA

10-20mg 5-10mg
1.

2.
3.

2 6

15
1.Zopiclone
2.
3.
4.
5.
phenothiazines
15 ~ 25

(Antipsychotic Drugs)
85

18.1 Benzodiazepepine(BDZ)-
18101

Hopan

OHOPA
Haloperidol
Hopan Tab 0.5mg

tab

, KOJAR

18102

Binin-U

18103

IBINI
Haloperidol
Binin-U inj 5mg/1ml.

amp

1 23 1 1
1 23 0.55mg
5mg

1.
2.
3.

4.

Lithium

15 ~ 25

Fluanxol

OFLUA
86

18104

Flupentixol
Fluanxol 3mg.

tab
Lundbeck-Denmark

Fluanxol Depot

IFLUA
Flupentixol
Fluanxol Depot inj 20mg

Amp
H.Lundbeck-Denmark
1. 3mg

2.

1. 315mg 20
60mg 1530mg50200mg 24

2. 2 0.5mg 2
3 1mg 11.5mg
3. 12mg
4mg
1.
2.
1.
2.

3.

1.Flupentixol decanoate

2.guanethidine

3.
87

4.
5.Flupentixol decanoate levodopa
metoclopramide piperazine
15 ~ 25

18105

Betamac

OBETM
Sulpiride
Betamac 200mg

tab
Sawa-Japan

18106

Sulmatyl

OSULM
Sulpiride
Sulmatyl 50mg

tab

, PL
1.
2.
3.
4.

1 150mg 3
(Gonadotropin
Prolactin )

()
88

18107

1.(Atropine, Methylscopolamine )

2. Digitalis
Digitalis
15 ~ 25

Morefine(Wintermin)

OWINT
Chlorpromazine

Morefine(Wintermin)100mg

tab

,, 609

50450mg

1.
2.

15 ~ 25

18.2 (serotonin dopamine antagonists)

18201

Abilify
89

18202

OABIL
Aripiprazole
Abilify Tab 10mg

tab
-JAPAN
, A-008 / 10
1. D2 D3 5-HT1A 5-HT2A

2. D4 5-HT2C 5-HT7 1 H1

3. D2 5-HT1A

1. KetoconazoleQuinidineFluoxetine Paroxetine
50%
2. 15 -30 C

1.
15-20mmHg
2.MMS
MMS
3.
4.

ARIPIPRAZOLE
KetoconazoleQuinidineFluoxetin Paroxetine ARIPIPRAZOLE

15 ~ 25

Lodopin
OLODO
Zotepine
Lodopin 50mg.

tab
Astellas-Japan
, 651

90

1. dopamine
2. serotonine
3.

4.

1.

2.
()(
) -
3.
a.
b.
c.
d.
e.
f.()
g.
()
4.

1.()
2. Barbiturates (
)
3. Epinephrine Phenothiazine

4. Terfennadine Astemizole ( QT
)
D

1.()
2. Barbiturates (
)
3. Epinephrine Phenothiazine

91

4. Terfenadine Astemizole ( QT
)
1. Epinephrine( Epinephrine
)
2.(1)(Barbiturate )
Atropine ()
(2)Ethanol()(3)Metoclopramide Domperidone

3.()
Zotepine first-pass metabolism
7%~13% 97%
13.7-15.9
15 ~ 25

18203

Risperdal solution

ORISL
Risperidone
Risperdal 1mg/ml(30ml/bot)

bot
Janssen-Belgium

18204

Apa-Risdol F.C

OAPAR
Risperidone
Apa-Risdol F.C. Tab. 1mg

tab

RIS/1/WWIN

18205

Risperdal
ORISP
Risperidone
Risperdal 2mg.

tab
Janssen-Korea
, RIS/2

18206

Perisdone
92

OPERD
Risperidone
Perisdone 2mg

tab

Catalepsy
1.

2.
3.
1. 1 2 1mg 2 2 2mg 3
2 3mg 3 2
3mg
2. 2 0.5mg
2 0.5mg 2 12mg

3.15
4. 2 0.5mg 2 12 mg

1.
2.

3.
4.Siadh
1.
2.

3.
4.
5.
6.

RISPERDAL
1.

93

2. Levodopa
3.Carbamazepine C
Carbamazepine

4.Phenothiazines - risperidone

1. 12

2. 9-hydroxy-risperidone
risperidone N-
30
9-hydroxy-risperidone 24
risperidone
9-hydroxy-risperidone 45
15 ~ 25

18207

Utapine

OUTAP
Quetiapine
Utapine F.C Tab 200mg

tab

, UN453, 200MG
serotonin(5HT2)
dopamin D1 D2

2 50mg100mg200mg
300mg 300~450mg




Seroquel ( carbamazepine)
quetiapine Seroquel

15 ~ 25
94

18208

Clopine

OCLOP
Clozapine
Clopine 100mg

tab

Z/E SWISS

18209

Mezapin
OMEZA
Clozapine
Mezapin 100mg

tab

, PANBIOTIC
1.
2. Serotonin
3.

1 25mg 1~2
200~450mg
600mg 150~300mg
1~2

1.
2.
3.
4.
1.
2.
3.
4.
1.
95

2.
3.
15 ~ 25

18210

Zyprexa

OZYP10
Olanzapine
Zyprexa 10mg

tab
Eli Lilly-England
, LILLY4117

10

10

1.ALTAGT

2.

15 ~ 25

(Antianxiety drugs)
19.1 Benzodiazepanines
19101

Anzepam (Ativan)

OATIV
Lorazepam

Anzepam (Ativan) 0.5mg.

tab


96

 , SK/206

19102

Neuropam

INEUR
Lorazepam
Neuropam inj 2mg/ml

amp

Limbicsy Stem

Efficacy

1.
2.

3.
4.
5.

1.5mg~3mg
3mg~10mg
1. 2~3

2.
3.
4. 2~4mg

5.
6.6~12
7.6
8. Neuroleptices

1. Minor TranquilizersChlordiazepoxide, Diazepam,
and Meprobamate
2. Benzodiazepine

3.

97


1. BENZODIAZEPINES
2.
3.
4.
15 ~ 25
2~ 8

19103

Vanconin (Valium)

OVAL2
Diazepam
Vanconin (Valium) 2mg.

tab

, 181

19104

Dupin
IVALI1
Diazepam
* Dupin inj 10mg/2ml

"C.C.P."

amp

1.
GABA GABA

2.Amnesia

3.

4.

1.
2.IV
3.IV
4.
5.
98

 1.1 /2mg 3
2.1 /2mg 3
3. 530mg
4.1 /1020mg
5. 1030mg
6.1 1030mg
3
8. 1020mg 20mg
9.1 /10mg 1 2
10. 20mg 10mg 1 4



TagametCimetidine Benzodiazepine

15 ~ 25

19105

Alepam

OALEP
Oxazepam
Alepam15mg

tab
Alphapharm-Australia
, OM15/G
Benzodiazepine

1. 3~4 10~30mg
2. 3~4 10mg

1.
2.

3.
4.
5. 2

99

19106

6. OTC
7.6
8.

Benzodiazepines 2

1. PhenothiazinesBarbiturates MAO

2.
15 ~ 25

Erispan

OERIS
Fludiazepam
* Erispan 0.25mg

tab

, 017


1 0.75mg 3
1.

2.
3.
4.

1.
2.
3.

1.3

2.
1.
2.Phenothiazine Barbiturie Acid
Monoamin
100

 15 ~ 25

19107

Amprazo

OALPR
Alprazolam
Amprazo 0.5mg.

tab

, CCP C60
Benzodiazepine

Benzodiazepine
18

Benzodiazepine
CNS CNS
15 ~ 25

19108

Lexotan
OLEX1
Bromazepam
Lexotan 1.5mg

tab

101

 , ROCHE/1.5
1.

2.

1.5~3 mg 3
6~12 mg 2~3
()

1.
2.
1. psychoactive substance
Lexotan
2. Lexotan -
narcotic
analgesics antipsychotics/
antiepileptic drugssedative antihistamines

3.euphoria
4.
Benzodiazepines Cimetidine Bromazepam

15 ~ 25

19109

Relac

ORELA
Buspirone
Relac 5mg

tab

102

 , 432
1. BZD

2. D2-doopamine

15mg
2~3 5mg/ 60mg

1.

2.

Fluoxetine Buspirone
15 ~ 25

19110

Serenal

OSERE1
Oxazolam
Serenal 10mg.

tab

, SANKYO 107

kg 12mg
3 1020mg

1.
2.

MAOI

rat 14C-Oxazolam 30
103

 30-60 peak
15 ~ 25

19111

Calmday SC

OCALM
Nordazepam
Calmday SC Tab 5mg

tab
S.A WILL PHARM-BELGIUM


10mg/day,;

1.
2.
3.

4.
5.
6.
7.
,
1. 2.
15 ~ 25

19.2
19201

MELIXOL S.C.

OMELI
Flupentixol 0.5mg/Melitracen 10mg
Melixol S.C. TAB

tab



2 1 2
1 1
104

1.
2. guanethidine
3.MAO
4.
15 ~ 25

(Antidepressants)
20.1
20101

Sinequan

OSINE
Doxepin Hcl

Sinequan 10mg

cap
PFIZER AUSTRALIA
/

20102

Ichderm Cream
EICHD
Doxepin Hcl
Ichderm Cream 15gm.

tub

15gm

H1 H2

105

 3 25-50mg( 300mg)12
4 34 15
75% 7

1. doxepin
2.
3. MAOIs
1.MAOIs doxepin MAOIs
MAOIs
2.Cimetidinecimetidine TCAs
anticholinergic effect cimetidine TCAs
cimetidine TCAs
3.
4. CYP450 IID6 (poor metabolizers)
TCAs CYP450 IID
TCAs
TCAs
( SSRIs)phenothiazinescarbamazepinequinidine(
) Type1C ( propafenoneflecainideencainide )

15 ~ 25

20103

Tofranil

OTOFR1
Imipramine
Tofranil 10mg.

tab
CIBA GEIGY (JAPAN)
, CG. 209

20104

Imimine (Tofranil)
OTOFR
Imipramine
Imimine (Tofranil) 25mg.

tab
106

1 2575mg 1 200mg
300mg

1 2550mg12 1 2

1.

2.

1. Dibenzazepine
2.
3.
4.
1. Monoamine

2. Choline Adrenaline

15 ~ 25

20.2 (SSRI)
20201

Fluvoxin F.C

OFLUV
Fluvoxamine Maleat
Fluvoxin F.C 50mg

tab

, WST, F/03
107

 Serotonin
Fluvoxin
Fluvoxin
Fluvoxin
Fluvoxin 15
()
100~200mg
300mg 50mg
150mg 2~3 Fluvoxin

Fluvoxin
Fluvoxin
Fluvoxin

1. Fluvoxin
2.77% Fluvoxin
Fluvoxin 3.5g(5mg*70 )

1. MAOI

2. Fluvoxin

Fluvoxin
3. Fluvoxin

4. Fluvoxin
5. Fluvoxin
6.Fluvoxin Benzodiazepines
Fluvoxin
1. Fluvoxin
(Warfarin,Phenytoin,
Theophylline)
2. Fluvoxin Propranolol Warfarin

3. Digoxin Atenolol

77%
15 ~ 25

108

20202

Kinloft

OKINL
Sertraline
Kinloft 50mg

tab

, 200, S / K

2-4 6-8

50mg 200mg 150mg
50mg


MAOI
MAOI
MAOI
15 ~ 25

20203

Kitapram F.C.
OKITA
Citalopram
Kitapram F.C. 20mg

tab

, SK
Citalopram Serotonin
Cholinergic muscarine receptors,histamine receptors -adrenoceptors
Citalopram
24

Citalopram Citalopram

.
20mg 60mg
109

20204

65 40mg

MAO 14

MAO
Citalopram 24
80%
12

15 ~ 25

Setine

OSETI
Paroxetine
Setine Tab 20mg

tab

, TS22 STD
5-HT Serotonin

20mg 10mg
50mg
Paroxetine

MAO Inhibitors
MAO Inhibitors

Paroxetine

5-HT Paroxetine Tryptophan
Serotonin
110

5-HT

Phenytoin

Paroxetine

Isozyme
1.NortriptylineAmitriptyline Imipramine Desipramine
2.Phenothiazine Phenothiazine Thioridazine
3.Type IC Propafenone Flecainide
15 ~ 25

20205

Uxetine

OUXET
Fluoxetine
Uxetine 20mg

cap

/, CCP. B54
Serotonin

20mg
2 1 20mg 80mg
1.

2.
3.
1. 10%~15%

2.1%
3.
4.
5.
111

6.

MAOI
MAOI
1.Tryptophan

2. 2

3.
4. Diazepam Diazepam
23 norfluoxetine 79
68
15 ~ 25

20.3 (SNRI)
20301

Valosine SR

OVALO
Venlafaxine Hcl
Valosine SR Cap 75mg

cap

, STD , 283

O-desmethyl venlafaxin(ODV)
(serotonin)(noneinephrine)
dopamin ODV
(muscarinic)(histaminergic) -1

(anticholinergic)(sedative)
ODV

1. 75mg/day
2. 150mg/day
225mg/day75mg/day

112

225mg/day
350mg/day
375mg/day
3.XR 2 2 225mg

1. MAOI
MAOI14
MAO 7
2.

3.
4.
5. 2
6. C
C
1.
2.
15 ~ 25

20.4 (SDRI)
20401

Wellbutrin Sustained-Release
OWELL
Bupropion hydrochloride
Wellbutrin Sustained-Release 150mg

tab
GSK
, GX CH7
1.Bupropion (catecholamine)

2. Bupropion
(noradrenergic)/(dopaminergic)

3. Bupropion
/
4.Bupropion
113

1.
a. 150mg Wellbutrin SR
150mg
300mg/

150mgWellbutrin SR 150
8
b.
Wellbutrin SR

2.
Wellbutrin SR
150mg 3 150mg 2
8 150mg
300mg 7
1.():
2.:
3.:

4.:
5.:
6./:
/

7.:
8.
Bupropion
1. Wellbutrin SR Bupropion

Wellbutrin SR :
;;;

3.(
) Wellbutrin SR
4. Bupropion
114

 Bupropion

5. Bupropion
Wellbutrin SR

6. Bupropion (NTS)

1.Wellbutrin SR Bupropion
2.Wellbutrin SR
3.Bupropion
4.Wellbutrin SR (MAOIs) MAOIs
14 Wellbutrin SR
1.Bupropion P450 2B6
hydroxybupropionWellbutrin SR CYP2B6
( orphenadrine, cyclophosphamide, ifosphamide)
Bupropion CYPD6 P450
Bupropion hydroxybupropion CYP2D6
2. Bupropion desipramine
Bupropion 7 Wellbutrin
SR CYP2D6
3.Wellbutrin SR (
SSRIsTCAs)

4. Wellbutrin SR CYP2D6

5.Bupropion ( carbamezpine,
phenobarbital,phenytoin)
6. Bupropion levodopa
levodopa Wellbutrin SR
Wellbutrin SR (NTS)
7.(CNS)Bupropion

Wellbutrin SR
15 ~ 25

20.5 (MAOI)
115

20501

Clopine

OCLOP
Moclobemide
Clopine 100mg (Clozapine)

tab

Z/E SWISS

20502

Euta

OEUTA
Moclobemide

Euta 150mg/F.C

tab

, ST 150

1. 300mg 2~3
1 150mg
600mg
2.
3. 1/2 1/3

1.

2.

Benzodiazepine
3.

4.Tyramine

116

 1.
2.
1. Ibuprofen

2.Cimetidene Cimetidine

3.

15 ~ 25

20.6
20601

Lidin

OLITH
Lithium Carbonate
Lidin 300mg

tab

, 031 U/L

norepinephrine serotonin
norepinephrine cyclic AMP

1.
2. 57 1500
2000mg
7 3 5001200mg
3. 5001000mg
4.
1.
2.( 1.5mEq/l )
CNS

CV
GI--
117

20602

1.

2. Lithium

1 4
1
( 24 )

15 ~ 25

Mesyrel

OMESY
Trazodone

Mesyrel 50mg.

tab

, LO

20603

Trazo

OTRAZ
Trazodone
Trazo 50mg

tab

, CH 27
CNS

150mg 3~4 50mg/day
400mg
600mg 1 50mg 2 100mg
3 150mg
118

()

1.

2.
3. carbamazepine

trazodone
15 ~ 25

(Anticonvulsants)
21.1
21101

Phenobarbital

OPHEN
Phenobarbital

* Phenobarbital Tab 32 mg "F.Y."

tab

Focal
Seizures

1.a. 2~4 16~32mg 2mg/kgb.
50~200mg 3~6mg/kgc. 120~200mg
1~6mg/kg
2. 30~50mg 600mg
3. 100~320mg 600mg

15 ~ 25

21.2 Hydantoine
21201

Phenytoin (Dilantin)
119

21202

ODILA
Phenytoin
Phenytoin (Dilantin) 100mg.

tab

, 215

Aleviatin(Dilantin)
IDILA
Phenytoin
Aleviatin(Dilantin) 250mg/5ml.inj.

amp

Jackson
1 0.3g 3
10 1 0.10.2g
0.1g
1 0.1g1 0.3g
1 0.3g1 1g

1.
2.

3.

Hydantoin
Bishydroxycoumarin DisulfiramIsoniazid

15 ~ 25

21.3 Benzodiazepanines
120

21301

Anzepam (Ativan)

OATIV
Lorazepam
Anzepam (Ativan) 0.5mg.

tab

, SK/206

21302

Neuropam
INEUR
Lorazepam
Neuropam inj

2mg/ml

amp

Limbicsy Stem

Efficacy

1.
2.

3.
4.
5.

1.5mg~3mg
3mg~10mg

1. 2~3

2.
3.
4. 2~4mg

5.
6.6~12
7.
8. Neuroleptices
121


Minor TranquilizersChlordiazepoxide, Diazepam,
and Meprobamate
Benzodiazepine

1. BENZODIAZEPINES
2.
3.
4.
15 ~ 25

21303

Rivotril

ORIVO
Clonazepam
Rivotril 0.5mg.

tab

, ROCHE 0.5

0.5~1mg 1.5~3mg 3~6mg

4~8mg 3~4 20 mg

1.
2.
3.
4.

15 ~ 25
122

21304

Vanconin

OVAL2
Diazepam
Vanconin (Valium) 2mg.

tab

, 181

21305

Dupin
IVALI
Diazepam
Dupin inj 10mg/2ml .
, 181
amp

1.
GABA GABA

2.Amnesia

3.

4.

5.
1.
2.IV
3.IV
4.
5.
1.1 /2mg 3
2.1 /2mg 3
3. 530mg
4.1 /1020mg
5. 1030mg
123

6.1 1030mg
3
8. 1020mg 20mg
9.1 /10mg 1 2
10. 20mg 10mg 1 4

Benzodiazepines
TagametCimetidine Benzodiazepine

15 ~ 25

21.4
21401

Depakine Lyophilized

IDEPA
Valproate Sod Lyophilized
Depakine Lyophilized inj 400mg/4ml

vial
GLAXO WELLCOME-FRANCE

21402

Depakine

ODEPA
Valproate
Depakine 200mg

21403

DEPAKINE SOL

tab
SANOFI WINTHROP-FRANCE

ODEPS
Valproate
DEPAKINE SOL 200MG/ML 40ML

bot
SANOFI WINTHROP-FRANCE
AminobutyrateAminotransferase -AminobutyricacidGABA

124


1 2~4 15mg/kg 5~10mg
30mg/kg

500mg

1. 2
Fibrinogen
2. Amylase

3. Thrombocytes
4. Ketones Falsepositive
5. 3
Phosphatase
Transaminases
40 15~20mg/kg

1.VPA MAO
2.
3.
15 ~ 25

21404

MgSO4

IMAGS
Magnesium Sulfate
MgSO4 inj.10% 20ml.

amp

1.
2.

3. Tendonreflex EndPlate

1~10mg.I.V I.M.
125

21405

1 4gm 5ml
50100mg 12
5 1020
300mg

2mg4mg

Anilide

15 ~ 25

Convulex

OCONV
Valproic Acid
Convulex 500mg.

cap
R.P. SCHERER GMBH-GERMANY
, 500

Aminobutyrate-Aminotransferase -Aminobutyricacid
GABA

1 2~4 15mg/kg 5~10mg
30mg/kg

500mg

1. 2
Fibrinogen
2. Amylase

126

21406

3. Thrombocytes
4. Ketones Falsepositive
5. 3
Phosphatase
Transaminases
40 15~20mg/kg

1.VPA MAO
2.
3.
15 ~ 25

Gatine

OGATI
Gabapentin
Gatine 300mg

cap

, PU22

21407

Neurontin
ONEUR100
Gabapentin
Neurontin 100mg

cap
PFIZER-PUERTO RICO
, NEURONTIN 100MG
1.

pentylenetetrazole

2. GABA(gamma-aminobutyric acid)
GABA
3. GABA GABA GABA

1.
127

2. 9001800mg/ 300 400mg (

) 1800mg
2400mg
12
3. gabapentin

4. 1

1.

2.2074 7
(1.2)
(0.8)(0.6)(0.6)(0.6)
1.
2.
()

3.:(CNS)

1. gabapentin
(phenytoin,carbamazepine,valproic acid
phenobarbital)
2.Cimetidine: cimetidine 300mgQID gabapentin
14 10 cimetidine
gabapentin gabapentin
cimetidine
3. AUC 2.5mg norethindrone
acetate 50mcg ethinyl estradiol gabapentin
(400mg TID),norethindrone,ethinyl estradiol
gabapentin norethindrone Cmax 13

4.(Maalox)Maalox gabapentin 20
128

gabapentin Maalox 2 5
gabapentin Maalox 2
Gabapentin 50%-60%
1.5-4 L-amino
acid
300mg 60% 1600mg
35%Gabapentin
<3%Vd 50-60L0.6-0.8 L/kg
Gabapentin CNS gabapentin
20% 80%
5-7
12
Gabapentin 10

15 ~ 25

21408

Tegretol

OTEGR
Carbamazepine
Tegretol 200mg

tab
UBINOVARTIS-TW
, CG G. K

1.10~20mg/kg/1 100~200mg/1~5 200~400mg/
6~10 400~600mg/11~15 600~1000mg/

2. 200~400mg/
200mg 3~4

100mg 2
3.200mg 2~3

1.
129

21409

2. Diazepam

3. 1
1
4.

5. 2

6.

7.
8.
9.

1.

2. Macrolide Antibiotics
ErythromycinLsoniazid Verapamil.Diatiazem
DextropropoxypheneViloxazine Cimetidine

EEG ECG
Diazepam
15 ~ 25

Topamax

OTOPA
Topiramate
130

21410

Topamax 25mg

Tab
GILAG AG-SWITZERLAND
, TOP, 25

Topmax

OTOPA1
Topiramate
Topmax 100mg

Tab
GILAG AG-SWITZERLAND
, 100 TOP
GABA
GABA

1 2 25mg 50mg
200 400mg 2
1.
2.

3.
4.
1.
2.
3.
4.
5.
6.
7. 6 8
8.

9.
10.
11.



PHENTYTOIN VALPROATE
131

 CARBAMAZEPINE
PHENYTIONVALPROATE
topiramate
topiramate 2030ml/minTopiramate

100400mg
48
100mg
Cmax 6.76g/ml topiramate 50mg 100mg
21
15 ~ 25

21411

Trileptal Film Coated

OTRIL
Oxcarbazepine 300mg
Trileptal Film Coated Tab 300mg

tab
NOVARTIS-SWITZERLAND
, TE CG
1.Trileptal oxcarbazepine MHD
oxcarbazepine MHD

2.

3.Oxcarbazepine MHD
-

1. 2400
4200
2. Trileptal 600mg(8
10mg/Kg/day) 600mg2400mg
600mg

3. 810mg/Kg Trileptal
30mg/Kg
10mg/Kg/day
132

 46mg/Kg/dayTrileptal 2

4.Trileptal

5.( 30ml/min)

1.

2.
3.
4.
5.

6.

7.
8.
Stevens-Johnson syndrome
1. carbamazepine 25~30%
Trileptal
2.

3. Oxcarbazepine
(:)

4.Trileptal
Trileptal
5.Trileptal

6.Trileptal

7. Trileptal
Trileptal
8.

133

9.
Stevens-Johnson syndrome(SJS)(TEN)
C

1.Trileptal CYP2C19
2.Oxcarbazepine MHD dihydropyridine calcium
( carbamazepine) CYP3A4
CYP3A5
3. Trileptal 1200 phenytoin
40% Trileptal 1200mg/day
phenytoin
4.Phenobarbital Trileptal Phenobarbital
15%
5. P450 ( :carbamazepine, phenytoin
phenobarbital) MHD 2940%
6.Trileptal
ethinylestradiol(EE) levonorgestrel(LNG)EE LNG
4852% 3252% Trileptal
7. Trileptal felodipine (AUC) 25%

8.

Trileptal

10%110%
0.1%1%0.010.1%0.01%
1. 600 Trileptal MHD
24.9 /(mol/L) 6
2. 40% MHD

3.Oxcarbazepine MHDMHD Trileptal

MHD glucuronic acid

4.Oxcarbazepine 1.3 2.3

MHD 9.31.8
15 ~ 25
134

 (Antiparkinsonism drugs)
22.1
22101

Akineton

OAKIN
Biperiden

Akineton 2mg.

tab
ABBOTT -GERMANY
, /

22102

22103

Biperin
OBIPER
Biperiden
Biperin 2mg

tab

, UN407/UNION

Bipiden

IBIPI
Biperiden
Bipiden 5mg
, UN407/UNION

amp

(akinesia)
(seborrhea)(euphoria)

(incoordination)

1. 3~4 2mg
2.- 1~3 2mg-2mg 30
4

1.

135

22104

2.

3.

4.

5.

6.
7.

AntiparkinsonQuinidine Tricyclic Antidepressant

15 ~ 25

Artane (B.H.L)

OARTA
Trihexyphenidyl
Artane (B.H.L) 2mg.

tab

, BHL 2

1. 1mg 3~5 2mg
15mg 6~10mg 3~4 5mg

2. 1mg 12 1mg

C
136

15 ~ 25

22105

Norflex

ONORF
Orphenadrine Hcl
Norflex

Tab
3M-AUSTRALIA
, 3M N/X
Antihistamine

2 100mg

1.
2.

3.

15 ~ 25

22.2
22201

Amantadine

OAMAN
137

22202

Amantadine
Amantadine 100mg

Cap

Dopamine

A
100mg 2
Levodopa 100mg
1 1 100mg 2

15 ~ 25

Parlodel

OPARL1
Bromocriptine
Parlodel 2.5mg

tab
UBINOVARTISTW
, X. C
Acetycoline

138

22203

Ergot Alkaloids
15 ~ 25

Celance

OCELA
Pergolide Mesylate
Celance 0.05mg/tab

tab
AEGIS-CYPRUS

D1 D2

D2
Levodopa/Carbidopa
3

1.
2.PERGOLIDE Levodopa
Levodopa
3.
4.

PERGOLIDE
PERGOLIDE Levodopa
HaloperidolPhenothiazines
15 ~ 25

22204

Parkryl

OPARK
Selegiline
Parkryl tab "M.S.
139

tab

, LO/1
Levodopa
Levodopa

12 510mg

10mg

Selegiline 10mg MAO

C

Dopamine
1.Decarboxylase Levodopa
2.
15 ~ 25

22.3
22301

22302

Madopar HBS
OMAH
Levodopa 100mg/Benserazide 25mg
Madopar HBS 125mg

cap

/, ROCHE

Madopar

OMAD
Levodopa 200mg/Benserazide 50mg.
Madopar 250mg.

tab

, C. HE.
Dopamine
140

dopamine dopamine - dopamine

levodopa
levodopa dopamine
levodopa dopamine
levodopa levodopa
benserazide Madopar
41
levodopa
Madopar HBS
3-6

Madopar

1 Madopar 62.5
1/2 Madopar 125 3-4

300-800 mg levodopa 75-200 mg benserazide 3

4-6

3-6 1 125 Madopar

( 3 )
Madopar HBS Madopar

Madopar Madopar

(on-off phenomena)
Madopar HBS
Madopar Madopar HBS
Madopar
2-3 50%

Madopar HBS Madopar HBS

Madopar

Madopar HBS 2-3

Madopar HBS 250 mg

141

 Madopar HBS
()
Madopar HBS Madopar

Madopar Madopar HBS

Madopar
Madopar 30 1

L-dopa

1.
2.

3.
4. MADOPAR

5.
6.
7. 2~3

25

Cycloporpane Halothane
trihexyphenidyl Madopar levodopa
trihexyphenidyl Madopar HBS
levodopa
Madopar HBS levodopa 32%
levodopa AUC 30-50%

Metoclopramide levodopa
Levodopa bromocriptineamantadine
selegiline domperidone

Madopar HBS Madopar
3 levodopa
20-30%- Madopar HBS
Madopar(
142

)Madopar HBS
Madopar 50-70% levodopa
Madopar HBS
(5 )

Levodopa -
57 Levodopa AUC 12%
levodopabenserazide -

Levodopa (-)(
)
Levodopa dopamine
homovanillic acid dihydroxyphenylacetic acidLevodopa
catechol-O-methyltransferase 3-O-methyldopa
15 Madopar
benserazide levodopa
levodopa 3-O-methyldopa catecholamines (dopamine
noradrenaline) phenolcarboxylic acids
Benserazide trihydroxybenzylhydrazine

levodopa levodopa 1.5

(65-78 )( 25%)levodopa
430 ml/min

15 ~ 25

(Drug for Migraine)

23.1
23101

Fluzine
143

23102

OFLUZ
Flunarizine
Fluzine 5mg

cap

, STD/136

Suzin
OSUZI
Flunarizine
Suzin 10mg

cap

/, STD521

10mg/

()

(EPS)
1.

2.
15 ~ 25

23103

Seglor

OSEGL
Dihydroergotamine
Seglor 5mg.

144

cap
SANOFI--SYNTHELABO-FRANCE
/
1.
2.

1.
2.
3.
4.

Troleandomycin, Erythromycin
15 ~ 25

(Dementia Therapeutics Agents)

24.1
24101

Aricept

OARIC
Donepezil

Aricept 5mg.

tab

, ARICEPT /5

10mg/

145

24102

()

(EPS)
1.

2.
15 ~ 25

Hodrin

OHODR
Dihydroergotoxine
Hodrin 1.5mg

tab

, WD H/D

() 3 1.5mg

15 ~ 25

24103

Witgen

OWITG
Memantine

Witgen 10mg

146

tab

, LO/10
NMDA
GLUTAMATE , memantine NMDA

5mg, 5mg, 20mg

PH ,
PH
NMDA-antagonist memantine L-dopa, dopaminergicagonists,
anticholinergics barbiturates neuroleptics
memantine antispasmodic agents, dantrolene baclofen
memantine
amantadine NMDA-antagonist
ketamine dextromethorphan memantine phenytoin
cimetidine, ranitidine,
procainamide, quinidine, quinine nicotine amantadine
(renal cationictransport system) memantine
memantine
hydrochlorothiazide(HCT) HCT Memantine
CYP 1A2, 2A6, 2C9, 2D6, 2E1,3A monooxygenase
epoxide hydrolase
15 ~ 25

147

 (Central Nervous System Stimulants)

25.1
25101

Ritalin

ORITA
Methylphenidate

()Ritalin Tab 10mg

tab

,A, B CG

25102

Concerta E.R
OCONE
Methylphenidate 18mg
Concerta E.R Tab 18mg

tab
ALZA-USA
, "ALZA 18"

1. 23 10mg 30~40
1 1 4
2.~6 6 2
5mg 1 510mg 60mg

1.
2.
3.
4.
5.

148

6. 4~5
7. 1

8.
9. Tyramine

1. Phenylbutazone

2. MAO Furazolidone
3. Guanethidine
4. Phenothiazines Propoxyphene
15 ~ 25

(Brain Metabolism Strengtherner)

26.1
26101

Trental

OTRE4
Pentoxifylline

Trental 400mg.

tab

26102

Trental
ITREN
Pentoxifylline
Trental inj. 20mg/cc 5cc

Amp
HOECHST MARION ROUSSEL-GERMANY

3 2

149




Pentoxifyllin

15 ~ 25

26.2
26201

Glycetose

IGLY3
Glycerin/Nacl/Fructose
Glycetose inj.300ml.

Bot

1.
2.
3.

12 1 200500ml 500ml 23
12
500ml 30

1.
2.
3.
4.
5. Ketone
15 ~ 25

150

 (Anesthetics)
(General Anesthetics)
27.1
27101

Anexate

IANEX
Flumazenil

Anexate inj 0.1mg/ml 5ml

Amp
CENEXI SAS-FRANCE

1. Benzodiazepine
2.- Benzodiazepine
Benzodiazepine
3.-
5% Dextrose Nacl 0.9%
0.2mg
1.15 60
0.1mg
2. Benzodiazepine
3. 0.3mg
4. Benzodiazepine 5mg
Diazepam 5mg Midazolam

1.
2.

Anexate

1.
2. benzodiazepines (
)
1. Benzodiazepine
151

2. Benzodiazepine Zopiclone,
Triazolopyridazine
3.Benzodiazepine
15 ~ 25

27102

27103

Anesvan
IANES1
Propofol
Anesvan inj 200mg/20ml

vial

55 2.0 2.5mgkg

1.
2.

1.()
2.Fresofol 1 16

15 ~ 25

Etomidate

IETOM
Etomidate

Etomidate Lipuro 20mg/10ml

amp
B.BRAUN MELSUNGEN -GERMANY

152

 1. 0.2~0.3mgkg
2. 10 0.1mgkg 5
15 ~ 25

27104

Aerrane

IISOF
Isoflurane
Aerrane(Isoflurane )

bot
BAXTER-PUERTO RICO
Halothane

1.5~3%1~3.5%
1.
2.
3.
4.
1.
2.

1. Epinephrine
2.
15 ~ 25

27105

Ketalar
IKETA
Ketamine
Ketalar inj.50mg/cc.10cc.

vial

1.
153

27106

2.
3. Nitrous Oxide
4.
5.

1.
2.(1)(2)
(3)( NO)
InductionIV Route-1~4.5mgkg 0.5mgkg
1~2mgkg
IM Route-6.5~13mgkg 3~6mgIb 15 ~25
Maintenance
0.1~0.5mg
kg IV Diazepam 20mg
1.
2.
3.:,,,,
1.
2.Postoperative Confusional States

1.
2.
1. Barbiturates Narcotics
2.

Analeptics
15 ~ 25

Sevoflurane

ISEVO
Sevoflurane
Sevoflurane(Ultane) 250ml

bot
ABBOTT-UK
SEVOFLURANE

1.8-5% Nitrous Oxide
154

 1.
2.


15 ~ 25

(Local Anesthetics )
28.1
28101

Cocaine

ECOCA
Cocaine

Cocaine

bot

1.

2.
3.

1.1~5% 5~10%

2.Adrenaline

15 ~ 25

28102

Primalido cream
EPRIM
Lidocaine /prilocaine
Primalido cream

tub

lidocaine
600mg

155

1. 2gm

2.6 12 2
2
Prilocaine
Metahemoglobin
()
1. 6
2.

( Sulphonamide)

15 ~ 25

28103

Xylocaine

IXYL1
Lidocaine
*Xylocaine 2% for IV 5ml
2%

amp
ASTRAZENECA-SWEDEN
lidocaine
/

1. 1 1 50~100mg1~2mg/kg 1~2

2. 1 1~2mg 1
4mg ()

10~20
1. Anilide
2.()
IV 1020 IM 5
15 6090 12
(40%80%)(90%)

156

 15 ~ 25

IXYLO
Lidocaine
Xylocaine inj.2% 20cc/vial
2%

vial
ASTRAZENECA-FRANCE
lidocaine
(amide)
(excitable
membrane)

1.

2.2%a. epinethrine 7mg/kg(<500mg)

epinephrine 4.5mg/kg(<300mg)b.5300mg
4mg/kgc.20300mg
d.() 100mg 200mge.
50100mgf. 200
300mg 90
3.1% 4 750mg
-

1.()( IV
)( CNSCV )
2.( P-R QRS )

3. lidocaine
isoproterenol (electric pacing)

4.

Adams-Stokes wolff-prkinson-white SAAV

157

IV 1020 IM 5
15 6090 12

(40%80%)(90%)

15 ~ 25

28105

Xylocaine Spray

EXYL10
Lidocaine
Xylocaine Spray 10% 50ml
10%

bot
ASTRAZENECA-SWEDEN
lidocaine
(amide)

(excitable membrane)

10mg xylocaine
3 3
20
20 400mg lidocaine
1-5

1.
2.

3.

Lidocaine ( tocainide)
lidocaine
Xylocaine
10-15 1-5
15 ~ 25

158

28106

Xylocaine Jelly

EXYLO
Lidocaine
Xylocaine Jelly 30gm.

tub
RECIP KARLSKOGA-SWEDEN
Xylocaine 2%

(20-30 )(5
)
Lidocaine

12
12
6 mg/kg 24
20ml(400mg)
5-10mg
10-20mg
lidocaine 400mg
2ml

Adams-Stokes wolff-prkinson-white SAAV

15 ~ 25

28107

Marcaine Spinal

IMAR1
Bupivacaine Hydrochloride
Marcaine Spinal inj. 0.5% 4ml.
159

amp
ASTRAZENECA-SWEDEN

28108

Marcaine

IMAR2
Bupivacaine Hydrochloride
Marcaine inj. 0.5% 20cc.

vial
ASTRAZENICA-FRANCE

28109

Marcaine Spinal Heavy

IMARC
Bupivacaine Hydrochloride
Marcaine Spinal Heavy inj. 0.5% 4ml.

amp
ASTRAZENECA-FRANCE

1.
2.
3.
2.5mg/ml 5mg/ml


1.2.5100mg 2.512.5mg
2550mg
2. 50mg 46 152540mg
3.1025mg
4.75100150mg
5. 23
6.
7. 2mg/kg

1.

2.

160

 1.

2.

1.
2. BierBlock

15 ~ 25

(Drugs acting on the musculokeletal system)

('Addictive Analgesics )
29.1
29101

Durogesic TTS

EFENT25
Fentanyl

* Durogesic TTS 25ug/hr

LABORATORIOS BETA S.A

29102

Fentanyl
IFENT
Fentanyl
Fentanyl inj.0.05mg/ml.10ml.

amp
BODENE (PTY)
Fentanyl u-
fentanyl

0.3-1.5 ng/ml 2 ng/ml

1. DUROGESIC
DUROGESIC 25mcg/h

2.a.2g/kg
161

b.2-20g/kg
c.20-50g/kg
20-50g/kg

3. :
50-100g/kg

()()

1.
DUROGESIC
2.Fentanyl

3.Fentanyl
Durogesic fentanyl
DUROGESIC
fentanyl DUROGESIC
C

morphine
DUROGESIC 72 fentanyl
Fentanyl (copolymer release
membrane) fentanyl
DUROGESIC fentanyl 12-24
72 Fentanyl
DUROGESIC 72

DUROGESIC 24 fentanyl
17 ( 13-22 ) 50% DUROGESIC 72
20-25 DUROGESIC fentanyl
DUROGESIC fentanyl
(IV infusion)
fentanyl
20%
Fentanyl
162

 75% fentanyl 10%

9%
fentanyl 13-21%
15 ~ 25

29104

29105

Pethidinae
IDEME
Pethidine(Meperidine)
Pethidinae inj.50mg.

amp

24 1/10

50100mg

1.
2.
3.
4.
5.

THIOPENTONE
1. MAO
2.AMPHETAMINE BARBITURATE CIMITIDINE MAO
TRICYCLIEANTIDEPRESSANTS CNS
15 ~ 25

Morphine
OMORP
Morphine
Morphine 10mg.

tab

, M
163

29106

Morphine
IMORP
Morphine
Morphine inj. 10mg/ml

amp

10mg 20mg 50mg

1.
2.
3. 3672

4. NALOXONE 400ug
kg 510ug

15 ~ 25

29107

Tramal

OTRAM
Tramadol
Tramal

50mg

cap
FARMACENTICI FORMENTI SPA-ITALY
/
164

29108

Tramal
ITRAM
Tramadol
Tramal inj. 50mg/ml 2ml

amp
GRUNENTHAL-GERMANY

100mg PethidineHCI 100mg Onset15~20

Duration4~5 ( 400mg)

1.1~2Amp(50~100mg)
1~2Amp(50~100mg)
2. 400mg
1 3~4 1
3.

1.

2.
3.

4.

()
(MAO)

15 ~ 25

165

29.2
29201

Naloxone

INALO1
Naloxone Hcl
Naloxone inj 0.4mg/ml

amp

1.PIOID RECEPTOR

2. 12 35

SCIMIV IV (1)IV 2 (1~4

) (2)IV 2~3 0.4~2mg 10mg
(3) 0.1~0.2mg
(4)IV 0.9%NaCl 5%Glucose 500ml
2mg(4g/ml)0.4mg/hr0.005mg/kg 2.5g/kg/hr
(5)Challenge test 0.2mg0.5ml 30
0.6mg 20

1. Opioids Opioid
2.
15 ~ 25

166


(Non-Addictive Analgesics and Anti-inflammatory Drugs)
30.1 Cox-2 NSAID
30101

Celebrex 100mg

OCEL1
Celecoxib

Celebrex 100mg

cap

30102

Celebrex 200mg
OCELE
Celecoxib
Celebrex 200mg

cap

Cox-2 Cox-1

100200mg 200mg
1.2.3.
4.
5.
1.
2.
3.
4.
5.
6.
7.

C
1. 2. 3. 4. ACE
5. 6.

ACE fluconazole
167


97%11.2 3
57%27%
15 ~ 25

30103

Bodopine

OBODO
Etodolac
Bodopine 200mg

cap

1. pyranocarboxylic acid (NSAIDs)

2. inducible cyclooxygenase(COX2:
cyclooxygenase ) consititutive
cyclooxygenase(COX1:cyclooxygenase
) prostaglandin biosynthesis antiinflammtory,
analgestic antipyretic

3.
threshold
4.Onset 30
5.

1. 200~400mg
2. 200~400mg
3. 1200mg

1.
2.

3.
D

1.aspirin NSAIDs asthmarhinitis

urticaria
2.15
1.( warfarin)
168

2. aspirin
3. cyclosporin cyclosporin
4. methotrexate methotrexate
methotrexate
5. digoxin digoxin
6.Etodolac ACEIs loop diuretics
15 ~ 25

30104

Mesulid

OMESU
Nimesulide
Mesulid 100mg

Tab
HELSINN BIREX-IRELAND

1.
cyclooxygenase-2(COX-2) cyclooxygenase-1(COX-1)
2.:
cytokine()

interleukin-6,urokinase

1.
2.
3.
4.
5.
100mg
400mg 30~80mL
30mL

(<0.1%)

1.

2.
169


3.
(: )
1.
2. 1 2 B

3 D
3.: nimesulide
(
30mL) 12
1. NSAIDs Salicylates: NSAID

2.Haparin Ticlopidine:

3.:

4.:
5.:

6.Methotrexate: NSAIDs methotrexate

7.Pentoxifylline:
8. GlibendamideWarfarinDigoxin
Cimetidine

30105

Meloxin

OMELO
Meloxicam

Meloxin

Tab

7.5mg

, YSP/75
1. enolic acid NSAIDs

2.

170

COX-2( COX-1)
3. COX-2 NSAIDs COX-1

meloxicam
NSAIDs

1. 15mg 7.5mg
2. 7.5mg 15mg
3. 7.5mg
4. 7.5mg
5. 15mg
6. 5mg
7. 15mg()

C
(aspirin)
1. NSAIDs Salicylates: NSAID

2.Haparin Ticlopidine:

3.:

4.:
5.:

6.Methotrexate: NSAIDs methotrexate

7. GlibendamideWarfarinDigoxin
Cimetidine
15 ~ 25

171

30.2 NSAID
30201

Flur Difen Patch

EFLUR
Flurbiprofen
Flur Difen Patch

(Prostaglandin)

30202

1.
2.

3.

4.

1.
2.

3.
B

1. aspirin NSAIDs NSAIDs

2.NSAID methotrexateMTX
MTX
3. Warfarin

Focus gel
EFOCU
Piroxicam
Focus gel 10mg/gm 40gm

Tube

172

 1.(Cyclooxygenase)
(Prostaglandin)
2. 1% Piroxicam

24 13gm

1.

2.
3.()

1. aspirin NSAIDs NSAIDs
2.NSAID methotrexateMTX
MTX
3. Warfarin

30203

Meitan F.C.

OMEIT
Diclofenac Potassium
Meitan F.C. 25mg

Tab

, ME

30204

Voren

OVORE
Diclofenac sodium
Voren 50mg

Cap
173


/, YSP VRCP

30205

Diclofenac Supp

EVOR1
Diclofenac
Diclofenac Supp 12.5mg

EA

Meitan Vottaren

50150mg 200mgday
100150mgday 23
3 1/2 3~5 1/2~1
6~8 1 9~11 1~2
1
150mg

1.

2.
3.

4.
5.
1.
2.

a.

b.
3.
a.
174

30206

b.
c.
4.

5.
6.

7.
a.
b.
c.
8.

9.
10.

3 /

FDA Pregnancy CategoryC

1.
2.
3.
4.
5.
6.Aspirin
7.
1.(Li)

2.(Aspirin)

Keto E.M.

OKET2
Ketorolac
Keto E.M. 10mg
175

30207

Cap

Keto inj.

IKETO
Ketorolac
Keto inj. 30mg/ml

Amp


1.

2.

3.

4.

10mg 4-6
15

:
1.<65 : 60mg 30mg
2.>65 <50kg: 30mg 15mg
:
1.<65 :, 6 1 30mg
120mg/
2.65 <50kg: 6 1
15mg 60mg/
1.
2.

3.
4.
5.
6.
176

 1.

2.

3.

4.
5.

1.
2. aspinin NSAIDs
3.
4.
1.Protein-bound Drugs: ketorolac

2.Nonsteroidal Anti-inflammatory Agents: aspirin NSAIDs

NSAIDs
3.Anticoagulants and Thrombolytic Agents:ketorolac
( haparinwarfarin dextrans)

4.Diuretics: ketorolac prostaglandin

5.Methothrexate: ketorolac methothrexate

methothrexate
6.Lithium: lithium lithium

7.Probenecid: probenecid

8.ACE inhibitors: ACEIs

(15~30)

30208

Ketoprofen

OKETP
Ketoprofen
Ketoprofen

50mg
177

30209

Cap

, 30408

Ketoprofen

IALON
Ketoprofen
Ketoprofen inj. 25mg/ml 2ml

Amp

NSAIDs aspirin

30210

1.-1 3 50mg 1 4 2
-1 2 50mg
2. 150-300mg 3-4
300mg
3. 1/2-1/3
1.-
2.-

3.-

1.
2.

3.
D-
Ketoprofen
1. aspirin NSAIDs NSAIDs
2.NSAID methotrexateMTX
MTX
3. Warfarin

Depyretin

OSCAN
Acetaminophen
178

30211

Depyretin 500mg

Tab

, 867 VPC

Anti-Phen Syr.

OANTS
Acetaminophen
Anti-Phen Syr.24mg/ml(1Bot=60ml.)

Bot

CNS

1 1~2 (7~12 )1 1/2~1 7

3~4 12 10ml6~12 5ml

3~6 2.5ml3 38.5
4~6 5
1.
2.
3.
1.
2.
3.
4. 150mg/kg
B
Acetaminophen
1.
2.

179

30212

Bokey

OBOKE
Aspirin
Bokey 100mg

Cap

/, YSP.BKCP
1. (Cyclo-oxygenase)

Thromboxane
2.
3.Thromboxane (
) Salicylate
Acetyl Salicylic Acid
Prostacyclin
4.Acetyl Salicylic Acid

1.

2. Acetyl Salicylic Acid

3.
4.()

1.
2.

aminoslicylic acid
aspirin 2g/d

180

 (15-30)

30213

Indalgin(Indocin)

OINDO
Indomethacin
Indalgin(Indocin) 25mg

Cap

/
1.

30214

2.

25mg 23 50mg 3

1.
2.

1. aspirin NSAIDs NSAIDs

2.NSAID methotrexateMTX
MTX
3. Warfarin
(15-30)

Napton S.R
ONAPT
Naproxen
Napton S.R 750mg

Tab

, NAPTON
(Cyclo-Oxygenase)(Prostanlandins)
Thromboxan
1
181

30215

14

2 250mg

1.
2.

Sodium Bicarbonate 13

Norgesic

ONORG
Orphenadrine citrate/Paracetamol
Norgesic 450mg

Tab
3M-AUSTRALIA
, 3M N/C
Orphenadrin
Paracetamol

1. Orphenadrine

2.

3. Orphenadrine

Orphenadrine

182

 1. Amantadine, , Butyrophenones,Phenothia Tricyclic

antidepressants.
2.

30216

Sconin solution

OSCON
Ibuprofen
Sconin solution 20mg/ml 60ml

Bot


(Prostaglandin)

6 12 102.5( 39.2)
0.25ml 102.5( 39.2)
0.5ml 6~8
2.0ml

6 12 6~8
0.5ml 2.0ml

1.5ml 2.0ml 3 4
1.0ml

4 6 20ml
400mg

4 20ml

60ml-160ml (15ml 4 20ml30ml 40ml

3 4 )

Ibuprofen
183

1.

2. STEVENS-JOHNSON (
)LYELL ()

3.

4.(TRANSAMINASE)
5.

6.
7.
8.
1.
2.()
()

3.

4.

5.

6.
7.

1.
2.
3.
4.
184

5.
6.
7.(ASPIRIN)
1. aspirin NSAIDs NSAIDs
2.NSAID methotrexateMTX
MTX
3. Warfarin
1.
2.

30217

Suloril (Clinoril)

OSULI
Sulindac

Suloril (Clinoril) 200mg

Tab

, WD 200
1.

2. 90% 2-4
7.8 Sulfide 15.4

3. Sulfone Sulfide

4. 50% 25%
5.

(
)

2 400mg

1.
185

2.
3.()

4.

5.

6.

1.
2. Aspirin

1. Aspirin Sulfide Metabolite

2. Probenecid Probenecid

30218

Synotec

OSYNO
Tiaprofenic Acid
Synotec 200mg

Tab

UC 04
(Prostaglandin)

3 200mg

Aspirin

186

30.3
30301

Metalcaptase

OMETA
D-Penicillamine 300mg

Metalcaptase

Tab
HAUPT-GERMANY

Penicillamine

T- 1Gm

Wilson
(Cystinuria)

300~600 mg
5~10 mg

900~1.8g

1.
2. 3
3 7~10 1 1
3. 1 6 1
4.
Pyridoxine25 mg

Wilson

5. 6

1. Wilson 1mg
2.(Cystinuria)

187

30302

Peitil

OPEIT
Glucosamine Sulfate 250mg
Peitil

Cap

/, PEILI CO4
1.

2.Mucopolys Accharides

1. 2 2 6
15
2.
8 3 2 15
3~4 2 2 15

1. Causaltherapy 1
2.
3.()

30303

Plaquenil

OPLAQ
Hydroxychloroquin 200mg
Plaquenil
188

Tab

, 200 HCQ
DNA S

1.20mg/kg
2.80mg/kg 3

1.
2.(G-6-PD )
3. 3
C
HYDROXYCHLOROQUINE
HYDROXYCHLOROQUINE

30.4 ( Antigout Agents)

30401

Allopurinol

OALLO
Allopurinol 100mg.
Allopurinol

Tab

, SHIN/YUNG
Hypoxanthine
Xanthine Oxidase(Xanthine Oxidase Hypoxanthine Xanthine
Uric Acid )

1 200mg~300mg 2~3

1.

2.
189

30402

3.
4.
5.
1. 1
1 (100mg/Tab)
2.
3.()
()

1.

Oxipurinol

Allopurinol

2. Allopurinol
Dicumarol,Sulfinpyrazone,Mercaptopurine,Azathioprine,Ampicllin,
Amoxicillin Thiazide Diuretics
15~30

Beenrone

OBEEN
Benzbromarone50mg
Beenrone

Tab

, Y/S
1.

2.

1 2-3

190

GOTGPT Alkaliphosphatase

1.
2.
Colchicine
3.

4.
5.
6.

1.
2.
colchicine

(15-30)

30403

Colchicine

OCOLC
Colchicine 0.5mg.
Colchicine

Tab

, SK/300

1 24~48

1 3~4mg 6~8
0.5~1mg / 0.5mg

1.

2.

191

30404

3.

4.
1.

2.
()
3.()

4.1 0.5mg
3~4 1 1 34mg
5. 0.51.0mg

ClarithromycinErythromycinTelithromycin
(15-30)

Narcaricin

ONAR1
Benzbromarone 100mg
Narcaricin

Cap

/, NARCARICIN
1.

2.

100mg 68

1.
2.
192

 Colchicine
3.

4.
5.
6.

( 20ml/min )

Colchicine

30405

Sulfin Tab

OSULF
Sulfinpyrazone 100mg
Sulfin Tab

Tab

1 2 100~200mg
1 2 100~400mg
( 800mg)
1.
2.
3.BUN
1.
2. 2000~3000ml

3.
4.

5. 6~12
3~6 Colchicine

6.
193

Pyrazoline

1. Allopurinol
2. Aspirin
3. Aminosalicylic Acid Cephalosporins, Daspone,Indomethacin,
Nitrofurantoin, Penicillins
4.Probenecid
5. Sulfonylurea
6. Warfarin Coumarinl
7.Aluminum Nicotinate.Dioxide,
Mecamylamine, Pyrazinamide
8.Cholestyramine
9. Colchicine

(Cholinergic Agents)
31.1
31101

Vagostin inj

INEOS
Neostigmine 0.5mg/1ml

Neostigmine inj.0.5mg/1ml.

amp


Cholinesterase Acetylcholine

Curare (Tubocurarine)
1~3 0.25~1.0mg
1mg 5mg

.
1. Succinyl Ch-line

194

2.

3.

1.

2.

corticosteroid

anticholinesterase

31103

Mestinon

OMEST
Pyridostigmine Bromide 60mg

Mestinon

tab

1.
2.
3.
4.
2~3 1~3
1.: 4 60mg
2.: 3~4 20~30mg
3.: 2~4 60mg 1~3
4.: 60mg
-

1. 6 1
2.

1.: 60mg 1
2. 5
195


1. corticosteroid

anticholinesterase

2. morphine barbiturates

31104

Salagen

OSALG
Pilocarpine 5mg

Salagen

tab
PATHEON YM INC-CANADA

IOP
[]1.2. IOP
3.

1.

2 1-2

1.

2.
3.

4.
C

1.SALAGEN Carbachol

2. SALAGEN
196

 ( Skeletal Muscle Relaxants)

32.1
32101

Chlorzoxazone (Solaxin)

OBENZ
Chlorzoxazone 250mg

Chlorzoxazone (Solaxin)

Tab

1.

2.

34 200400mg

1.
2.

3.

4.

1.
2.
3.
4.

1.
2. Phenothiazine Barbituric Acid
MAO

197

32102

Topeson

OTOPE
Tolperisone 150mg
Topeson

Tab



[]

150mg 3

3
3

, Benzodiazepines NSAID

32103

Norflex
ONORF
Orphenadrine
Norflex

Tab
3M-AUSTRALIA
, 3M N/X
Antihistamine

1.

2.
3.

300mg

198

32104

1.Orphenadrine

2.

3. Orphendrine

4.

Orphenadrine

1.Antimuscarine Orphenadrine Antimuscarine

Amantadinebutyrophenones
phenothiazines tricyclic antidepressants
2.Antimuscarine

Solofen

OSOLO
Baclofen 10mg
Solofen

Tab

, 242
2-4

1 3 12
8

1.

2. CNS

199

3.12
4.
5.

32105

Suflex

OSUFL
Mephenoxalone 200mg
Suflex

Tab

, YSP 47

1~2
8~10
6~15 3 1/2

()

32.2
32201

Tracrium

IATRA
Atracurium besylat25mg 2.5ml inj
200

Tracrium

vial
GSK-ITALY
1.

2. SuxamethoniumAnectine/Midarine

1. 0.30.6mg/kg90
0.10.2mg/kg

Atropine
AnticholinesteraseagentsNeostigamine Edrophonium
Recurarisation
95
2.
0.30.6mg/kg 0.30.6mg/kg

1~2

201

 Halothaneisoflurane Enthrane
Aminoglycosides, Polypeptide
Lithium, Magnesium Salts, Procainamide Quinidine

Suxamethonium Chloride
Atracurium
Anticholinesterase
Atropine Neostigmine

1. 2 C8 C
2. 30 C
3. 30 C1 8
4. Thiopentone

5.

32202

Esmeron

IESME
Rocuronium bromide50mg/5ml
Esmeron

amp
N.V.ORGANON-NETHERLANDS
Rocuronium bromide
(Curare ) N

NeostigmineEdrophonium chloride Pyridostigmine

0.6 rocuronium bromide
60
1.0 rocuronium bromide
60 0.6
rocuronium bromide 90
0.6 rocuronium
bromide 1.0 rocuronium bromide

202

0.15 rocuronium bromide

0.075-0.1 rocuronium
bromide(twitch height)
25% TOF2~3

Esmeron 0.6 mg rocuronium

bromide
10%
5-10 g/kg//min
5-6 g/kg/min

(1-14)(1-12 ) halothane
Esmeron
(0-1 )
//
//
0.6mg rocuronium bromide
0.075-0.1 rocuronium bromide 5-6
g/kg/min

30%
(lean body mass)
; Histamine release
1. Esmeron

2. Esmeron 24

Esmeron

Esmeron rocuronium bromide

Esmeron
Esmeron

1.halothane, ether, enflurane, isoflurane,methowflurane,

cyclopropane thiopentone, methohexitone,ketamine, fentayl,
gammahydroxy-butyrate, etomidate, propofol
203

-aminoglycoside, lincosamide, polypeptide,

acyamino-penicillin, tetracycline, metronidazole
-adrenergic blocking agents, thiamine, MAO inhibiting, quinidine, protamine,
-adrenergic blocking agents
2.neostigmine, edrophonium, pyridostigmine,aminopyridine

(
)

750 ED90 (135 mg/kg)

32203

Nimbex

INIMB
Cisatracurium besylat 10mg/5ml
Nimbex

amp
GSK-ITALY

1.
a. 0.15mg/kg 5
10 120

thiopentone/fentanyl/midazolam propofol 0.1
0.4mg/kg
b. 1 12
0.15mg/kg 510 120

2.
a. 1 12
89%99%
T1 3g/kg/min(0.18mg/kg/hr)
204

1.(pain
threshold)
2.

3.

4.(vagolytic)

5.
0.02mg/kg
6.

7.
B

NIMBEX

(Drugs Acting on the Cardiovascular system)

205

(Cardioactive Glycosides)
33.1
33101

Lanoxin

ODIGO
Digoxin0.25mg.
Lanoxin

Tab

, WELLCOME.X3A

33102

Lanoxin inj

IDIGO1
Digoxin 0.5mg/2ml
Lanoxin inj

Amp

33103

* Digoxin inj

IDIGO2
Digoxin0.25mg/1ml/amp
* Digoxin inj
""

Amp

2 6

1/23 0.1250.75mg
35 26 0.51.5 mg

2436 46 11.5mg
1 0.25mg
10
0.010.02mg/kg
206

2436 0.025mg/kg
24

1.
2.

3.
Digoxin
4. 2 Digoxin
C
Sinus Arrest

1. ColestipolCholestyramine
Neomycin
2. Quindine
AmiodaroneSpironolactone Triamterene
3.()
Digoxin
4.()

5.Thiazide Amphotericin B

(Antiarrhythmic Agents )
34.1
34101

Adenocor inj
207

IADEN
Adenosine 3mg/ml(2ml/vial)
Adenocor inj

vial

,
"ADENOCOR"

1.
3mg()
12
6mg
12
12mg
2.
adenosine 0.0375
0325mg/kg
6mg 13 20ml
12 12mg
6090mg 3

()

1./
2. adenosine
Adenocor
3. adenosine
adenosine

Adenocor
C

208

 1.()
2.()
3.
1. Dipyridamole adenosine Adenocor
Dipyhdamole Adenocor
Adenocor 4 ( 0.51.0mg)
2. Theophylline Caffeine adenosine
3. Adenocor

34102

Cordarone

OCORD
Amiodarone ( 50mg/ml)

3ml

Cordarone

Tab

, 200

34103

Cordarone inj
ICORD
Amiodarone 150mg/3ml
Cordarone inj

Amp

1. Wloff-P-Arkinson-White

2.

1. 200~800mg1 200~400mg
20 200mg
2.5~10mg/kg 20~120 1.2g8~10
5 2

209

34104

1.
2. 5mg/kg

3.
4.

1.
2.
3.
4. amiodarone
5. amiodarone
6.
7.
8. Benzyl Alcohol 3
Beta Segontin IsoptinMAO

Verelan

OVERE
Verapamil 120mg
Verelan

Cap

, 120/120

34105

Isoptin

OISOP
Verapamil 40mg

Isoptin

Tab
ABBOTT-GERMANY
210

 , 40

34106

34107

Isoptin inj
IISOP
Verapamil ( 2.5mg/ml)
Isoptin inj

2ml

Amp
ORION-FINLAND

1. 80120mg tid
2.
a.( digitalis) 240320mg 34
b. PSVT( digitalis) 240480mg 34
48
3. 80mg tid 360480mg

12 2.5mg

1.
2. 90mm-Hg
3. Sick Sinus Syndrome
4.
5.
6.
-Blocker

Xylocaine inj.

IXYLO
211

34108

Lidocaine 2% 20cc/vial
Xylocaine inj.

vial
ASTRAZENECA-FRANCE

AV

1
50100mg 12
5 1020
300mg

2mg4mg

1.

2.

Anilide

Cimetidine

Quinidine

OQUIN
Quinidine 200mg.
Quinidine

cap

212

 , NYSCO/Q01

1. 1 100~200mg

2. 1 3 6~8 1 200mg
2 1 400mg600mg
1~2 1 4 5 6

3.
1 400mg1 5 3

4. 1 200~600mg 1~3
QRS

1. quinidine cinchonism

2. ECG
sodium lactate
3.
()

4. 200mg
C

quinidine (cinchona) (
) quinidine
(left
213

bundle branch block)

1.

2.

3. Neostigmine, Edrophonium
4. Propranolol Phenytoin Barbiturates

5. Digoxin

34109

Rytmonorm

ORYTM
Propafenone 150mg
Rytmonorm

Tab

, 150

Wolff-Parkinson-White
kg 0.5~1mg 0.5mg kg
2mg
1.
..
2.SA AV
His Purinje System
1. 90~120
ECG
2. QRS-Phase 25 QT
3.

1.
2.
3.
214

4.
5.

1.Propafenone 2.8-11hr
17hr
2. 2-3hr
3. hydroxylation (CYP2D6)
Propafenone

34110

Heartcin

OHEAR
Ubidecarenone 10mg
Heartcin

Tab
TEIKOKU MEDIX-JAPAN

ATP

10mg1 1 1 3 30mg

35.1 (ARB)
35101

Cozaar
OCOZA
Losartan Potassium 50mg
Cozaar
50
Tab
215

 MSD-UK
, 952

50mg
3-6
100mg
()
25mg()

()
Losartan
Losartan

1.
(diezziness)
2.
(ACEI)
Losartan
receptor kinin prostaglandin

()
/
()
Losartan (
)

Losartan
()

(rennin-angiotensin system)

(creatinine)
Losartan

216

Losartan Losartan

Losartan
Losartan

Losartan

hydrochlorothiazide, digoxin, wafarin, cimetidine, phenobarbital
ketoconazole
angiotensin II (
spironolactone, triamterene, amiloride)

35102

Diovan

ODIOV
Valsartan 80mg
Diovan

Cap
NOVARTIS-SWITZERLAND
, D/V NVR

4-6
24 2-4
hydrochlorothiazide

1.
217

35103

2.( 80mg)

160mg

3.
4.
5.

1.

2.
3.
4.
5.
D

1.
diclofenac, furosemide, warfarin
2.spironolactone, triamterene, amiloride

Olmetec FC

OOLME
Olmesartan Tab 20mg
Olmetec FC

218

Tab
-TW
SANKYO
1.Olmesartan AT1 AT2 12500
-
2. 2
2
Olmesartan

1.Olmesartan
20 2
Olmesartan 40 40
2
2.(<40ml/min)
(
)Olmesartan

3.Olmesartan Olmesartan

1.

2.

1./-

Olmesartan
2.--
Olmesartan

/ Olmesartan

3.

Olmesartan
1. Olmesartan digoxin, warfarin

219

2. Olmesartan

35.2 (ACEI)
Angiotension converting enzyme inhibitors
35201

Accupril

OACCU
Quinapril 10mg
Accupril

Tab
GODECKE GMBH-GERMANY
, 1/0

1.
a.
10mg
80mg
b.
5mg
c.
5mg
2.
5mg
40mg

1.
2.
3.

220

35202

Acertil

OACET
Perindopril 4mg
Acertil

Tab
SERVIER-FRANCE
,:
angiotensin converting enzyme (ACE) inhibitors angiotension I

angiotension II (vasoconstrictor) aldosterone

bradykinin (vasodilator)
heptapeptide

1. 4mg
8mg
2. 2mg
4mg
3.
( Creatinine)
4. 3060mlmin 1530mlmin
15mlmin 2mg 2mg 2mg

1.
2.

3.

1.spironolactone, triamterene,

2.
3.Allopurinol
221

procainamide

4.

35203

Captopin

OCAPT
Captopril 25mg
Captopin

Tab


ACE

25mg
50mg

1.()
BUN

2. 20% BUN
20% 5%(
)

3.

4.()

5.

222


6.2 15

7.

( 1%)

1.()

2.(
Thiazides )()
3.
(
Adrenergic )
4.-Adrenergic

5.
( Spironolactone, Triamterene Amiloride)

6.Indomethacin
( )
7.(Acetone)

35204

Renitec

OREN5
Enalpril 5mg
Renitec

Tab
MSD-UK
, RENITEC
223

35205

Enaril

OENAR
Enalpril 20mg
Enaril

Tab

, WEIDAR

35206

Sintec

OSINT
Enalpril
Sintec

20mg

Tab

, ST

1040mg 1 2
80mg

1020mg 1

(5mg )
1 1 1 20mg
1020mg1

23% 2%

1.(
)
2.

3.
4.

224



Enalapril

ACE
AmilorideSpironolactone
Triamterene
4.6 7 mEq/L
\

35207

Tanatril

OTANA
Imidapril 5mg
Tanatril

Tab

, TT 135
SH Angiotensin converting enzyme(ACE)
Imidapril Hydrochloride (Prodrug)
diacid (Imidaprilat)Imidaprilat
ACE angiotensin

5mg

2.5mg 10mg 20mg

10mg

1.

2.BUN
3.
4.
5.
6. GOTGPTALK-PLDH
7.
225

8.

1.

2.

3. angiotensin dextran cellulose sulfonate

apheresis apheresis

4. angiotensin acrylonitrile methallyl sulfonate

soidum (AN69)
5.

6. 24
7.
a.(
3mg/dl )
b.()
c.
8.
a.

b.
D

1.
2. angiotensin
3. dextran cellulose sulfonate apheresis
4. acrylonitrile methallyl sulfonate soidum (AN69)
5.
1.(spironolactone triamterene )

2.

226

3.() angiotensin (captopril enalapril maleate

lisinopril)

4.Indomethacin angiotensin (captopril ) indomethacin

35208

Tritace

OTRIT
Ramipril 2.5mg.
Tritace

Tab
SANOFI AVENTIS-ITALY

, 2.5

12 36
24

2.5mg

10mg
1.25mg

1.
2.
3.
4.
D

1.
2.
227

3.(Phenylbutaxone, Acetylsalicylic Acid,

Indomethacin)
4.

5.

35209

Zestril

OZEST
Lisinopril 10mg
Zestril
10

Tab
ASTRAZENECA-UK
, ZESTRIL
ACE
ACE
1
2.
,,,
10mg,, 20mg,.
CHF: 2.5mg, AMI: 5mg( 2 )
5mg

1. 1-5

2. 24
24
3.
4. Lisinopril
5.
D

indomethacin NSAIDS

228

35.3 ( Calcium antagonists)

35301

35302

Adalat
OADAL
Nifedipine 5mg
Adalat

Cap
BAYER-GERMANY

Nedipine

ONEDI
Nifedipine 10mg
Nedipine

Cap

, WEIDAR/NP0140

35303

Nifecardia SR FC Tab
ONIFE
Nifedipine 30mg
Nifecardia SR FC

Tab

Adalat
1.1 10mg1 3
2. 12 1 12 2
3. 2 1 1 2
2
Nifedipine
10mg 3 10-20mg 3
20-30mg 3 4
180mg
229

35304

Nifecardia
1 30~60

1. 90mm Hg

2.
3. 30

8
1.

2.

3.(
barbiturates )
4. DILTIAZEM NIFEDIPINE

Herbesser

OHERB
Diltiazem 30mg.
Herbesser

Tab

, TT120
230

35305

Hesor

OHESO
Diltiazem 60mg
Hesor

Tab

, 60

35306

Cardizem Retard

ODILT
Diltiazem 90mg.
Cardizem Retard

Tab
Q PHARMA-SWEDEN

1.
1 30mg Diltiazem HCl1 3
1 60mg1 3
2.
1 30~60mg Diltiazem HCl1 3

240 360

1. P-R
2. -

3. -
4.Diltiazem

231


1. Nifedipine Diltiazem Nifedipine 50%

2.Diltiazem Digoxin Theophylline Ditiazem

Digitoxin
3.
CyclosporinCimetidineImipramineCarbamazepine Midazolam

35307

Felo

OFEL5
Felodipine 5mg
Felo

Tab

, A EN

35308

Phelop

OFEL1
Felodipine 10mg
Phelop

Tab

, S FN

1 10mg

1.
2.
3.

felodipine
1. Digoxin Digoxin
2. Cimetidine Felodipine
3.Phenytoin, Carbamazepine Barbiturates Felodipine
232

35309

Amlobin tab

OAMLO
Amlodipine 5mg
Amlobin tab

Tab


(Slow Channel )
Dihydropyridine

1 1 5mg
10mg

Dihydropyridines Dihydropyridines

Thiazide -ACE Inhibitor

35310

Lasyn F.C. Tab

OLASY
Lacidipine 4mg
Lasyn F.C. Tab

Tab
233


, SY, L
Lacidipine
Lacidipine

lacidipine 4 mg
lacidipine 6 mg
lacidipine 8 mg

lacidipine 2mg QD

Lacidipine

35311

Doxazon

ODOXA1
Doxazosin 2mg
Doxazon

tab

35312

Doxaben XL

ODOXX
Doxazosin 4mg.
Doxaben XL
4

Tab


1-
(Resistance)

- Thiazide
Doxazon
1mg
12
234

 16mg

35313

Doxaben XL
4mg
8mg

quinazolinedoxazosin

Limy

OLIMY
Phenoxybenamine 10mg
Limy

cap

10mg 10mg
2060mg

35314

Tezopin

OTEZO
Terazosin 2mg
Tezopin
235

35315

Tab

, 3

Weson

OWESO
Terazosin 2mg
Weson

Tab

, EP

1mg 15mg
20mg

1. 1mg

2.

3.

4.

terazosin

35316

Kerlone
OKERL
Betaxolol 20mg.
Kerlone

Tab
SANOFI-FRANCE
, KE 20
236

35317

Betoptic-S Oph.Susp.0.25%

EBET1
Betaxolol 12.5mg/5ml
Betoptic-S Oph.Susp.0.25%

Bot
ALCON-USA
-1

1. 20mg 40mg
2. 10mg

1.
1 2 2
Betaxolol

2. 2 1
1
3. PilocarpineMioticsEpinephrine
Carbonic Anhydrase

1.

2.
3.
4. - -
-
Thyroid Storm -

5. Catecholamine -

6.
7.

8.
237


1. MAOIVerapamil
2.
3. 4550
4. AV
1.
2.

3.
4. Epinephrine
Atropine(12mg,I.V.)GlucagonBeta-Minetics

35318

Timolol 0.25% oph solution

ETIM1
Timolol (Maleate) 5ml
Timolol 0.25% oph solution

bot



Catecholamine

2 1 0.25%
0.5%
1 2
1 1
0.25%1 2 2

238

 1.
2.
3.
4.

1.

2.
3.

35319

Trandate

OTRAD
Labetalol 200mg
Trandate

Tab

, GS FC7

35320

Trandate inj.
ITRAD
Labetalol 5mg/ml 5ml
Trandate inj.

Amp

Labetalol alpha
labetalol beta-

labetal

[]
[]

1 2 1 1000MG
1~2 1 2
8000MG 2400MG
239


2~4
C

1.

2.
HALOTHANE,ENFLURANE,ISOFLURANE LABETALOL

35321

Atenolol

OATEN
Atenolol 100mg
Atenolol

Tab


-1
-2

1. 50mg 1 12
100mg

2. 50mg 1
100mg 200mg
3. 100mg 1 50mg 2 7

1.

2.
3.
240

4.

Salbutamol Isoprenaline
5.
Disopyramide
6. Verapamil

48
7. Clonidine
Clonidine
Clonidine
8. 48
Cyclopropane

9.
50mg

1. 2 3
2.Atenolol Verapamil Verapamil
3.

4.
sick sinus syndrome
Verapamil Atenolol
1~2mg
Isoprenaline 25 Micrograms
Orciprenaline 0.5 mg
Agonist
10mg Glucagon I.V.

35322

Concor

OCONC1
Bisoprolol 1.25mg.
Concor

241


Tab

35323

Concor Tab

OCONC
Bisoprolol 5mg
Concor Tab

Tab
MERCK KGAA-GERMANY

1. (-Receptor

(ISA)
2. Renin

1. 1/2 2 ( 20mg)
510mg
2.(Creatinine Clearance 20ml/min)
10mg
1.

2.
AV
3.

4.

1.

2.
3.

4.
5.

242

1.
III AV Blook

50 /

2.Pheochromocytoma -Blockade

1.
2. Nifedinine
3. Rifampicin

4. VerapamilDiltiazem

5. Clonidine Clonidine
Clonidine
6. Reserpine-MethyldopaClonidine Guanfacineg

7. Insulin
Atropine 0.5~2.0mg Orciprenaline
1~5(10) mg Glucagn

35324

Inderal

OINDE
Propranolol 10mg
Inderal

Tab

, 110
, ,

()

1.
a. 80mg 160320mg
243


b. 40mg23

80160mg 120240mg
c. 521 40mg
2 3 80mg
d.
1040mg 34
e.() 60mg 3
30mg
2.
a.
3 4 kg 0.25mg0.5mg
b.12 20mg 23 12

1.
2.

3.

4.(
5055 )
5.

6. Insulin

7. Adrenaline

8. Disopyramide,
9. Verapamil
48
10.
C

244

1.
2.
3.
4.()
5.
Atropine 12mg
10mg Glucagon
Gluca-gon110mghr Glucagon Glucagon
Iso-prenaline 25ug Orciprenaline
0.5mg

35325

Sectral

OSEC4
Acebutolol 400mg
Sectral
400

Tab

, SECTRAL 400

1. 400mg
200mg
400mg

Thiazide
2. 400mg
200mg
300mg 1200mg
3. 3
4001200mg

245

 1.

2.
Agonist
3.
4. EtherCycolpropane
Trichlorethylene

1. 10060
2.
3. Verapamil Verapamil

35326

Carvedil

Tab

OCARV
Carvedilol 25mg
Carvedil Tab

Tab

CCP,C69

1020mg
20mg
1.
2.
3.
4.
5.
6.
7.GOTGPTCPK
1.
2.

3.
4.

246

5. verapamil diltiazem

1.reserpine
2.
3.verapamil
4. disopyramideprocainamideajmaline

35.4
35401

Stable (Apresolin)

OAPRE
Hydralazine 10mg.
Stable (Apresolin)

Tab

, 232

35402

Apresoline inj
IAPRE1
Hydralazine 20mg
Apresoline inj

Amp

1.
247

35403

2.(IV IM)
3.
10mg 4 24 25mg
4 2 50mg 4

1. hydralazine (
)
400mg

2.
3. hydralazine ()
pyridoxine( B6)
4. hydralazine
hydralazine
5. hydralazine

hydralazine dihydralazine

(
)

(
)

Diazoxide

Esidri

OESID
Reserpine/Hydralazine/Hydrochlorothiazide
Esidri
248

Tab
-TW

(Reserpine)(Hydralazine)

(Hydrochlorothiazide)

36 23
1.

2.

3.

4.
5.
6.
7.

8.

9. SLE

1.
2.
3.

Bilirubin

()
Thiazide()
1.
249

2.L-DopahMAO
Digitalis Quinidine Barbital Catecholamine
ACTH Glycyrrhizin Tubocurarine

35404

Moduretic

OMODU
Hydrochlorothiazide 50mg/Amiloride 5mg
Moduretic

Tab

, MSD/917
Hydrochlorothiazide

35405

Amiloride Hydrochloride

1. 12
4 12
2. 12 4

3.( 1 )
4

1. Azotaemia
Amiloride Hydrochloride
2. Thiazide
3.Sulphonamide Thiazide

Natrilix SR

ONATR
250

Indapamide 1.5mg
Natrilix SR

Tab
SERVIER-FRANCE

Indapamide Thiazide sulfonamide indoline

Indapamide
Indapamide
Indapamide

Clonidine

1. 1 ( 90109mmHg)

2.
3.

4. 110129mmHg

5.( 130mmHg )
( Clonidine)
6.

Indapamide
:
()

Indapamide

()
FDA :B

251

:Indapamide

Thiazide
Sulfonamide
1.Cisapride QTc
QTc thiazide
torsades de pointes
2. Thiazide

Indapamide :

35406

Catapres

OCATA
Clonidine HCl 75ug
Catapres Tab

Tab

, 1C/1C
(cardovascular integrating
centers) -2

(renin)

1.
2.
3.
4.
5. 0.0750.150mg 214
0.450mg 0.300mg
(0.900mg) 1.21.8mg

252

 1.
2.

3.( 55 )

4.
5.
6. Raynaud's

Sick-Sinus Sydrome
1.
2. Tranquilizers()

3. -Receptor -Receptor

4.

36.1
(Antianginal Drugs-Coronary Vasodilators)
36101

Ismo-20

OISMO
Isosorbide 5-mononitrtate
Ismo-20

20mg

253


tab
, BM 3B

36102

Isobide Tab 10mg "WEIDAR"

OISOB
Isosorbide Dinitrate 10mg
Isobide Tab 10mg "WEIDAR"

tab
, I/S , WD

36103

0.1%Isoket soln for infusion

IISOK1
Isosorbide Dinitrite (10mg/10ml)
0.1%Isoket soln for infusion

0.1%
amp
SCHWARZ PHARMA AG-GERMANY

2~5
1~2 30 4~8

1. 20MG 20MG

2. 23 122
3. 12
4. 2mg 7mg
10mg

1.
2.

3.

Nitroglycerin
10~15mm/Hg
C
254

1.
2.

Sildenafil phosphodiesterase type 5 nitrate

NO Sildenafil nitrate

36104

NTG (Nitrostat)

ONTG
Nitroglycerin 0.6mg
NTG (Nitrostat)

tab
PFIZER-PUERTO RICO(USA)
, N 6

5
510

1.
2.

3.

1.
2.
1. Nitroglycerin alteplase(t-PA)
255

 tPA tPA alteplase

2. Sildenafil phosphodiesterase type 5 nitrate

NO Sildenafil nitrate

36.2
36201

Carditonin

OPERS
Dipyridamole 25mg
Carditonin

tab

36202

36203

Sancin
OSANC
Dipyridamole 50mg
Sancin

tab

Peysan F.C.Tab
OPEYS
Dipyridamole 75mg
Peysan F.C.Tab

tab

256


: 150-225
300-450
kg 510

1.
2.
B

36204

Heartcin

OHEAR
Ubidecarenone 10mg
Heartcin

Cap
TEIKOKU MEDIX-JAPAN

ATP

10mg1 1 1 3 30mg

36205

Sigmart Tab
OSIGM
Nicorandil 5mg
Sigmart Tab

tab
257

 CHUGAI-JAPAN
,, C-21F5
Sigmart
1. preconditioning

2.
3. Sigmart NO

Sigmart

15mg
14323 661 (46.1%)817 (
) 515 (3.60%) 63 (0.44%)
21 (0.15%) 20 (0.14%) 17 (0.12%)
1.
2.

Sildenafil citrate Vardenafil monohydrochloride

Sigmart
Sildenafil citrate(Viagra) Vardenafil monohydro-chloride (Levitra)
Nicorandil cGMP PDE-5
cGMP PDE-5 cGMP

(Prophylaxis of Atherosclerosis-Hypolipemic Drugs)
37.1
37101

Questran.

OQUES
Cholestyramine Pow

4g/pkg
258

37102

Questran.

PKG

9g 4g
Anhydrous Cholestyramine Resin

3 4gm(
1624gm)
120ml-180ml

2 cephalexin, clindamycin,
digitalis pentobarbital, phenobarbital, thiazide
tetracyclines, trimethoprim ADE K
1 4
6

Lipitor

OLIPI
Atrovastatin
Lipitor

tab
PFIZER

10mg

259

 , 10 PD/55

37103

Lipitor FC Tab

OLIPI40
Atrovastatin 40mg
Lipitor FC Tab

tab
PFIZER
PD157,

40
1. 3-hydroxy-3methylglutaryl-coenzyme A(HMG-CoA)
HMG-CoA mevalonate

2.
LDL- apo B
VLDL- TG HDL- apoIipoprotein A-1
(isolated hypertriglyceridemia)
LDL-VLDL-apo BTG-HDL HDL-
(dysbetalipoprotinemia) LDL-

1.()
(Fredrickson IIa IIb ) 10mg
1080mg
/ 2
4
LDL- NCEP LDL-
LDL-

2.
1080mg
( LDL apheresis)

3.
HMG-CoA fibrates
260

 1.
2.
3.
4.
5.
1.
2.
3. 24
6 12
4.

5. digoxin digoxin
6.

7.
niacin
8.
X

1. cyclosporine, fibric acid , niacin(nicotinic acid),

erythromycin azole
2. Maalox TC 35%
LDL-
3.Colestipol colestipol 25%
LDL- colestipol

37104

Lovasta

OLOVA
Lovastatin 20mg
Lovasta

tab

261

 , W

HMG-CoA

80mg
( 2 )
75mg100ml(1.94mmol1)
140mg100ml(3.6mmol1)

1.
312
2.

Gemfibrozil, Niacin(Nicotinic Acid)Erthromycin
Lovastatin Coumarin
Lovastatin

Erythromycin Lovastatin
Lovastatin
Fibrates Niacin(Nicotinic Acid)

37105

Lipo-Merz Retard

OLIP5
Etofibrate 500mg
Lipo-Merz Retard
262

37106

cap
MERZ PHARMA-GERMANY

1.

2.

1. 24
2.

1.
2.

Lipolin

OLIPL
Fenofibrate 100mg

Lipolin

cap

/, PEILI

37107

Fenolip

OFENO
Fenofibrate 200mg.
Fenolip
263

37108

cap

, CH51
Fenofibrate
VLDL APO-A1 HDL HDL
HMGOA reductase Acetyl COA
LDL receptors LDL

200mg 100mg 3

500mg/dl 1 4 100mg

1.
2.

1.
2.
3.

Gem-S

OGEMS
Gemfibrozil 600mg
Gem-S

tab

, ST

264

 1200mg

Helsinki Heart Study

Lopid

Prothrombin Time,
Prothrombin Time Prothrombin Time

(Agents Used in Hypotension and Shock)
38.1
38101

Adrenalin inj

IBOSM1
Epinephrine 1mg/ml.

Adrenalin inj

Amp

Epinephrine

0.5mg 515
0.250.5ml:10000 0.3mg 15

1.
2.
3.-
1.
2.
3.
265

4.
5.

6.
a.
b.
c.
d. Ampule
Ethanol
C

1.
2.
3.
a.
b.
c.
d.
e.
f.Cocaine
g.
1.
a.Cycolpropan Halothane Halsgen
b.Isoprenaline Catecholamine
2.
a.Monoamine Oxidase
b.(Imipramine, Amitriptyline )
c.(Oxytocin, Ergotamine )
3.
a.Digitalis ()
b.Quinidine( Ventricular Fibrillation )
c.[Thyroxine ]()

38102

Dobuject Inj.

IDOBU1
Dobutamine250mg/5ml
Dobuject Inj.
266

Amp
SANTEN OY(SCHERING OY)-FINLAND

1.(Inotropic Agent)

2. Dopamine Norepinephrine
Norepinephrine
3.Dobutamine Hydrochloride

1.
2.510mcgkg
2. 20mcgkg
3. 40mcgkg
4. 5000mgl(250mg50ml)

5. Dobutamine Hydrochloride
6. Dobutamine Hydrochloride
mcgkgmin

Dobutamine Hydrochloride
mcgkg
7.Dobutamine Hydrochloride 100200ugmin
10002000ugmin

1.
1020mmHg 515
5% Dobutamine Hydrochloride

2.

3.

4.
1%3%
267


1.
2.
3.

4.
5.()
B

1.Dobutamine Hydrochloride
2.

38103

Dopamin

IDOPA
Dopamine40mg/ml 5ml
Dopamin

Amp

1.LDopa
2. Norepinephrine Noradrenaline
3.

4.
5.
6.

1.
2. 5%
3. 25mcgkg
110mcgkg
2050mcgkg( 50mcg)

1.
2.
3.
268


4.
5.
Phentolamine(510mg) 1015ml
6.

7.

8.()
C

1. MAO
2. Guanethidine
3. Cyclopropane
4.
5. Phenytoin

38104

Levophed inj.

ILEVO
Norepinephrine 4ml
Levophed inj.

Amp
HOSPIRA(ABBOTT)-USA
-
(inotropic action)

CNS

269

 1. IV 8-12 mcg/min 2-4 mcg/min

2. IV 2 mcg/min 0.1mcg/kg/min
()
(extravasation)
1.() 5mg
10mg phentolamine 1015ml
2.
3.

4. norepinephrine

5. 5%
dextrose
6. atropine propranolol

(Hypovolemic shock)(
halothane)
furazolidoneguanethidine
methylodpahalotyhanecyclopropane

38105

Midorine

OMIDO
Midodrine Hcl 2.5mg
Midorine

tab

, PL/T03


1. 0.6g/kg
2. 1 1~2 1 1.25mg 1 2~3 1 1.25mg
270

()
( 60 )

()

(Peripheral Vasodilators)
39.1
39101

Escin

OESCI
Escin20mg
Escin

39102

tab

Aescin gel 15mg/gm

EAESC40
Escin 40g
Aescin gel 15mg/gm

tub

1.
2.
3.

2 20mg 1 120mg
271

 2-3

39103

Misudin

OMISU
Buflomedil 150mg.
Misudin

Tab

, S

24 (300600mg)

39104

Mylin

OMYLI
Gingo Biloba Extract 40mg.
Mylin

Tab

, G, SD/T84
1.

2.
3.
272

39105

4.

1 40mg 34

Sanyl

OSANY
Nicametate 50MG
Sanyl

Tab

, SANYL
1.
2.
3.
[]
[]
50~100mg 3

(Drugs acting on the blood system)

(Antianemic drugs)
40.1
40101

Desman inj
273

IDESM
Iron Dextran

Desman inj

amp


[]1.
1.2.5 50
5 100
10 200
10
2. 5 1.25
5-10 2.5 10

40102

100mg/2cc

Felinamine inj

IFELI
Thiamine/Disulfide/Pyridoxine
Hydroxocobalamine 10ml/amp
Felinamine inj

amp

40103

Ferall Soft Cap

OFERA
Ferrous Fumarate
Ferall Soft Cap

Soft

cap

Vit C
Vit C

folinic acid

274

40104

1-2

1.
2.
3.

Folic Acid

OFOLI
Folic Acid 5mg.
Folic Acid

tab

, 124
tetrahydrofolic acid
folic acid
1.
2.

1-2 1-2 1 2

1.
2.

3.
4.
5. 24 ()
35
275

1. BarbituratesPhenytoinPrimidone

2. Phenytoin Phenytoin

40105

Hitocobamin

OHITO
Mecobalamin500ug.
Hitocobamin

cap
HISHIYAMA PHARMACEUT
, HD218
1.

2.

3.

1500mcg

1.
2.

1.
2.

40106

Slow-Fe Folic
OSLFF
Ferrous sulfate / Folic acid 160mg
Slow-Fe Folic

tab
NOVARTIS-UK
/ CIBA, TP
276


1.1 1
2.1 2

1.
2.

40107

Putan Chewable Tab

OPUTA
Iron(III)hydroxide
polymaltose
complex
100mg
Putan Chewable Tab

tab


Hb

1. 100mg
100mg
2.Hb 90 / 100mg
50mg
3. 25 mg 50mg
1-2
12

1.

2.

1.

2. 1-2

3.
4.

277


5.

.(Anticoagulants)
41.1
41101

Fragmin inj
IFRAG
Dalteparin Sodium 10000IU/4ml
Fragmin inj

amp
PFIZER - BELGIUM
1.(Adhesivenes)
2.
3. Heparin
4.

100 // 12
100 // 12
1.
2.
3.
1. Heparin
2.(Hematoma)
3. Salicylates, Pyridamole

4.

Fragmin ,,,,
,,. Dalteparin sodium
,(Aggregation).
278


Protamin Sulfate

41102

Agglutex inj

IHEPA
Heparin Sod 25000U/5ml
Agglutex inj

vial

1.(Adhesivenes)
2.
3. Heparin
4.

1.:
SC 10,000 20,000 8 12 80,000
20,000 IV 10,000 4 6
5,000 10,000
IV IV 5,000 20,000 40,000
1,000ml
2.:SC 2 5,000 7
8 12 5,000
3./:IV 150 400

1. Heparin
2.(Hematoma)
3. Salicylates, Pyridamole

4.

Heparin
Protamin Sulfate

279

41103

*Orfarin Tab

OCOUM1
Warfarin Sod 5mg.
*Orfarin Tab

tab
ORION -FINLAND
, ORN/18
K

IIVIIIX X

10-15mg
3-6 heparin
6

1.
2.(
)
3.(
)()
4.

5. Heparin
6. 34 210

7.

8.
9.(PT)/
(INR)
10.?
warfarin
X

()
280

1.
Dipyridamole Indomethacin Oxyphenbutazone
PhenylbutazoneQuinidine Salicylates
Sulfinpyrazone
2.
BarbituratesCarbamazepine Ethchlorvynol Glutethimide
Griseofulvin HaloperidolPhenytoin, Rifampicin
K
3. Phenytoin

(Antiplatelet Agents and Thrombolyic Agents)
42.1 Thrombolytic agents
42101

Urokinase inj.

IURO6
Urokinase 60000IU

Urokinase inj.
60000

vial
YOSHITOMI PHARMACEUT
Streptokinase Plasminogen Plasmin

1.
2.
3.
4.
1 60,000 IU 7
60,000~240,000 IU 7
--

281

heparin 2
B

72

HeparinWarfarinArgatroban
AspirinDipyridamoleTiclopidine HCl
t-PA Nasalpase
(
Prothrombin )
Aprotinin
Urokinase

42.2 Antiplatelet agents

42201

42202

Trental
OTRE4
Pentoxifylline
Trental

400mg.

tab

Trental inj.

ITREN
Pentoxifylline20mg/cc 5cc
Trental inj.

Amp
HOECHST MARION ROUSSEL-GERMANY

282

 3100200mg

100-500 100-600
pentoxifylline1200
pentoxifylline

24
1200600
0.6
pentoxifylline 24
pentoxifylline 1200

1.Trental Inj. ACE
nitrates
2.

3. pentoxifylline theophylline
theophylline

42203

Licodin

OLICO
Ticlopidine 100mg.
Licodin

tab

, LC

1.
2.
3.()
23

283

42204

Misudin

OMISU
Buflomedil
Misudin

tab

150mg

, S

24 (300600mg)

42205

42206

Carditonin
OPERS
Dipyridamole 25mg
Carditonin

tab

Sancin

OSANC
Dipyridamole 50mg
284

42207

Sancin 50mg

tab

Peysan F.C.Tab

OPEYS
Dipyridamole 75mg
Peysan F.C.Tab

tab

: 150-225
300-450
kg 510

1.
2.
B

Dipyridamole adenosine adenosine
adenosine
10
adenosine
adenosine

42208

Pletaal

OPLET
Cilostazol 50mg
285

Pletaal

tab

, OG 31
(cAMP phosphsdiesterase(PDE3))
PDE cAMP
cAMP
HDL

(
)
Pletaal 100 mg
2
1./
2.(hematoma)
3.
4.
5.
6.
7.
8.
1.(
)
7 clopidogrel
2.(thrombotic thrombocytopenic purpura)
(<)
3.Clopidogrel ()
( aspirin NSAIDs)
4.

5.-

6.
Clopidogrel
C

286


1.
2.
1.Clopidogrel aspirin,heparin warfarin
2.NSAIDs naproxen clopidogrel
naproxen clopidogrel

3.clopidogrel CYP2C9
CYP2C9 ( phenytoin
tamoxifentolbutamidewarfarintosemidefluvastatinNSAIDs)

(Hemostatics)
43.1
43101

Tren(Transamin)

OTRAN
Tranexamic acid 250mg
Tren(Transamin)

cap

/, YSP TEC

43102

Tren inj.
ITRAN
Tranexamic acid
Tren inj.

500mg/5ml.

amp

1. Plasmin
Plasmino-gen activator Plasmin

2.Plasmin
Fibrin Plasmin
Fibrin
287


3-8 3-4
250mg-500mg 1-2
500-1000mg
500-2500mg

1.(
)( Heparin
)
2.Hemocoagulase

Tranexamic acid

43103

Vitamin K1 inj.

IVITK
Phytonadione 10mg/1ml.
Vitamin K1 inj.
k1

amp

K1 IIVIIIX X

1 1 1ml(10mg)
1.: 0.5-2mg
25mg 10~50mg

2.: 1~2 20~50mg

3.:1 2mg1 20mg
4. 0.5~10mg 25mg

1. K
288


2. IV
IV
()
3.
phytonadione ( 23
)
C

289