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Grappling with cancers like John McCain’s glioblastoma that break all the rules

A renewed focus on glioblastoma and other tough-to-treat cancers that break all the rules could open new avenues for treating all types of cancer.
Pancreatic cancer cells (nuclei in blue) growing as a sphere encased in membranes (red).

Arizona Sen. John McCain’s recent diagnosis of the hard-to-treat cancer glioblastoma stands in contrast to recent media reports that paint an optimistic picture of cancer treatment in America. A sampling of headlines includes “Cancer survival rates at all-time high” and “Cancer death rates continue to decrease in the United States.”

Driving much of the progress are emerging advances in three vital areas: cancer prevention and early detection, immunotherapy, and approaches that match patients to targeted therapies. These developments are

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