Professional Documents
Culture Documents
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1.
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1.
1-1
2.
1)
3.
2) 1,2-
1-2 GST
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1.
1-1
1-2
1)
2)
3)
4)
5)
6)
1-3.
1-3
1)
2) 1,2-
1-4 IARC
2.
2-1
2-2
3.
3-1
3-2
3-3
1)
2)
2.
2-1
2-2
2-3
3.
3-1
3-2
.
2011 3 SANYO-CYPS
12 5
3 3 7 2
4
9 :
.
1.
S
91 19 110 66 44
1 81 15
1991 1 74 15
2.
110 33 7 40
S
3.
B C
.
1.
1985 5 91 3 1
1991 4 6 1
1 1 1991 2006
2 2006
5m
1. 19912006
1
UV
UV
5m
2. 2006
2
1-1
4 2006
7 2006 UV
UV 5
1-2
1)
SDS
2)
1/10
SDS
3)
4)
1980
1980
2006 UV
1990 1 2 16 2 2
5)
1
3
1991 3
4 3 1
1985 1988
1:1
1989
1,2- 5060%%
1520%1,1,1 1520% 1,1,1- 95%
1991 4
1991 1997/98 1991 1992/93
1,2- 5060% 1520%1,1,1- 15
20%1992/93 1997/98 1,2- 4050%
4050% 110%1997/98
1
1997/98 2006
1,2- 98%2006 3
1997 16
9
3
1 15
1.
1,2-5060%1520%1,1,1-1520%
1988
1,1,1- 95%
19891991
1,2-5060%1520%1,1,1-1520%
19911992/93
1,2-5060%1520%1,1,1-1520%
1992/931997/98
1,2-4050%4050%110%
1997/982006
1,2-98%
2006
S
24 7 31
1997 3
S 1997
24 6 8
1989 1984
1989
1990 1 23
1 17 L 45 L
PRTR S 2001 1,2-
8300kg 1 300 1 24 L1.4
1997/98 2000
45L 2000
2 35L
2006 UV 5
6)
1997/98
2000
98%
1-3.
1)
2
1 2 ,
39464840m3/hr
7871293m3/hr 1
72007656m3/hr
2000m3/hr
2224 55%
2006 2008 UV 18582042m3/hr
1
1
2)
2.
3
PS
2-1
4
1
PS
3
1 4
1 820 1
4 2040 5 1
2
1
1
1990 1 2 16 300800
7
UV UV UV
UV
2-2
2-3
PS
1996 1
12 L 1996
3.
3-1
11
6 2 1
4 13
820 13
2545 36
7 2746 37 12
1 1 23 12
413
1,2-12
1985 1,2-
8
A
B
C
D
E
F
G
H
I
J
K
L
M
(35)
34
29
45
38
40
35
(44)
39
40
25
31
39
1962
1962
1969
1961
1969
1969
1969
1968
1969
1967
1978
1978
1971
13
13
8
10
11
8
17
14
10
12
9
9
7
12
11
11
18
19
20
15
20
15
13
7
13
11
85
90
95
2000
05
10
2
3
4
57
+ +
1 : 1,1,1-TCE
2 : 1,2-DCP (50-60%), DCM (15-25%), 1,1,1-TCE (15-25%)
3 : 1,2-DCP (40-50%), DCM (40-50%), (1-10%)
4 : 1,2-DCP
57 :
4.
: ,
: 1,2-DCP,
: , :
1,2-DCP : 1,2-,
DCM : ,
1,1,1-TCE : 1,1,1-
717 11
2.
720 14
S5,8
2 11
5 6
S8
4 1
S3,4
2 1
S6,7
S8
1991 2006 1,29
1
62 51 7 4
11 5
1 5 62 130 8.6
1,2 117 6.1 11
111 3.9
1,2- 18 3.3
2011 12 6
5 1991
2011 0.0121
6 SMR 50095% 1801100
0.00204 SMR 290095%
11006400 6
2900
62 1,2- 5 31
SMR 64095%
2401400 410095% 1500
8800
1/6
3-2
33 22 S
11 50%
33 22
1 S GTP 60 IU/L
10
1
1
.
1.
1-1
1)
U.S. NTP
2B6C3F 02,000 4,000 ppm F344/N
01,0002,000 4,000 ppm 1 6 5 102
0/500/4922/49 0/5023/48
21/48 22/5024/4933/49 3/5016/48
40/48U.S. NTP
2/501/504/50
5/50
-S-GST
3
P450CYP
GST
CYP
GST
S-
GST
GST 1
11
2) 1,2-
U.S. NTP 1,2-
250 mg/kg/
U.S. NTP 1,2-
F344/DuCrj 1,2-
5
01252505001000 2000ppm 1 6 5
13 2000ppm 1000 2000ppm
GTP
2000ppm
080200 500ppm 1
6 5 104 500ppm GTP
B6D2F1/Crlj 1,2-
6
03280 200ppm 1 6 5
104
1,2-CYP GST
7
GST
1-2 GST
GST
GST 1
GST
3
GST
Sherratt 8
GST T1-1 GST
GST T1-1
GST
12
1,2-
GST
1-3
1)
4 2
1 9 19ppm 2 10
39ppm 0 1
1
2
3
11 3 140ppm
280ppm475ppm
4 12 2 50100ppm350700ppm
4 2
3 2 2
3 1954 1 1 1986 7 1
13
SMR 2095% 5.256
1990 12 11 SMR
2 SMR
4 12
2) 1,2-
AST
ALT
6
1-4 IARC
IARC 2B
1,2- 3
13
14
IARC 1
2A
2B
2.
2-1
1,2-46%
54% 1.7 L/h
60210 ppm 130360 ppm 1
3 13
1,2-1997/98 2006
1,2-
GST
2-2
1
1,2-
40 ppm 90 ppm
3.
3-1
15, 16 4
14
15, 16
3-2
2005
2.61 /10 , 7.85 /10
75 3544 1/50
15, 17
S 1991 2006 1
62 SMR 290095% 1100
6400 1,2- 5 31
SMR 410095% 15008800
3-3
13
1,2-1991 2006 1,2-
100670ppm
GST
1,2- GST T1-1 GST T1-1
1 1,2-
13 12
1991 1997/98 80540ppm
GST
GST T1-1
2
12
15
1 CYP
18
1,2-
GST 1,2-
1,2-S
1997
.
S
1 1,2- 2
1,2-
16
.
1. .
A-2012-02
2012.
2. NTP (National Toxicology Program). Toxicology and carcinogenesis studies of dichloromethane
in F344/N rats and B6C3Fi mice (inhalation studies). NTP Technical Report 306, U.S. Dept.
Health and Human Services, Washington, DC. 1986.
3. .
2004.
4.
NTP
(National
Toxicology
Program).
Toxicology
and
carcinogenesis
studies
of
1,2-dichloropropane in F344/N rats and B6C3Fi mice (gavage studies). NTP Technical Report
263, U.S. Dept. Health and Human Services, Washington, DC. 1986.
5. Umeda Y, Matsumoto M, Aiso S, et al.
1,2-
, 0458. 2006.
7. . Ver 1.1, No.39, 1,2-
.
2004.
8. Sherratt PJ, Williams S, Foster J, Kernohan N, Green T, Hayes JD. Direct comparison of the
nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity.
Toxicol Appl Pharmacol 2002;179:89-97.
9. Tomenson JA. Update of a cohort mortality study of workers exposed to methylene chloride
employed at a plant producing cellulose triacetate film base. Int Arch Occup Environ Health
2011;84:889-897.
10. Hearne FT, Pifer JW. Mortality study of two overlapping cohorts of photographic film base
manufacturing employees exposed to methylene chloride.
1999;41:1154-1169.
11. Lanes SF, Rothman KJ, Dreyer NA, Soden KJ. Mortality update of cellulose fiber production
workers.
12. Gibbs GW, Amsel J, Soden K. A cohort mortality study of cellulose triacetate-fiber workers
exposed to methylene chloride. J Occup Einviron Med 1996;38:693-697.
13. Lanes SF, Cohen A, Rothman KJ, Dreyer NA, Soden KJ.
15. , .
2009:278-282.
16. , . 7, ,
1999:7-13.
17. , .
2006:322-330.
18. Bolt HM, Roos PH, Their R.
TEL 093-691-7288
shkumagai@health.uoeh-u.ac.jp
18