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2012 9

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1.

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1.
1-1

2.

1)

3.

2) 1,2-
1-2 GST

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1.
1-1
1-2
1)
2)
3)
4)
5)
6)
1-3.

1-3
1)
2) 1,2-
1-4 IARC
2.
2-1
2-2
3.
3-1
3-2
3-3

1)
2)

2.
2-1
2-2
2-3
3.
3-1
3-2

.
2011 3 SANYO-CYPS

12 5
3 3 7 2

4
9 :

.
1.
S
91 19 110 66 44
1 81 15
1991 1 74 15

2.
110 33 7 40
S

3.

B C

.
1.
1985 5 91 3 1

1991 4 6 1
1 1 1991 2006
2 2006

5m

1. 19912006

1
UV

UV

5m

2. 2006
2

1-1
4 2006
7 2006 UV
UV 5

1-2
1)

SDS

2)
1/10

SDS

3)

4)
1980

1980
2006 UV

1990 1 2 16 2 2

5)
1
3

1991 3
4 3 1
1985 1988

1:1
1989
1,2- 5060%%
1520%1,1,1 1520% 1,1,1- 95%
1991 4
1991 1997/98 1991 1992/93
1,2- 5060% 1520%1,1,1- 15
20%1992/93 1997/98 1,2- 4050%
4050% 110%1997/98
1
1997/98 2006
1,2- 98%2006 3


1997 16
9
3
1 15

1.

1,2-5060%1520%1,1,1-1520%

1988
1,1,1- 95%

19891991

1,2-5060%1520%1,1,1-1520%

19911992/93

1,2-5060%1520%1,1,1-1520%

1992/931997/98

1,2-4050%4050%110%

1997/982006

1,2-98%

2006

S
24 7 31

1997 3

S 1997

24 6 8
1989 1984
1989


1990 1 23

1 17 L 45 L
PRTR S 2001 1,2-
8300kg 1 300 1 24 L1.4

1997/98 2000
45L 2000

2 35L
2006 UV 5

6)
1997/98
2000

98%

1-3.
1)
2

1 2 ,

39464840m3/hr
7871293m3/hr 1

72007656m3/hr

2000m3/hr

2224 55%
2006 2008 UV 18582042m3/hr
1
1

2)

2.
3
PS

2-1

4
1

PS









3






1 4
1 820 1
4 2040 5 1
2
1
1
1990 1 2 16 300800
7


UV UV UV
UV

2-2

2-3

PS
1996 1
12 L 1996

3.
3-1

11
6 2 1

4 13
820 13
2545 36
7 2746 37 12
1 1 23 12

413
1,2-12
1985 1,2-
8

A
B
C
D
E
F
G
H
I
J
K
L
M

(35)
34
29
45
38
40
35
(44)
39
40
25
31
39

1962
1962
1969
1961
1969
1969
1969
1968
1969
1967
1978
1978
1971

13
13
8
10
11
8
17
14
10
12
9
9
7

12
11
11
18
19
20
15
20
15
13
7
13
11

85

90

95

2000

05

10

2
3

4
57

+ +

1 : 1,1,1-TCE
2 : 1,2-DCP (50-60%), DCM (15-25%), 1,1,1-TCE (15-25%)
3 : 1,2-DCP (40-50%), DCM (40-50%), (1-10%)
4 : 1,2-DCP
57 :

4.

: ,
: 1,2-DCP,
: , :
1,2-DCP : 1,2-,
DCM : ,
1,1,1-TCE : 1,1,1-

717 11

2.

720 14

S5,8

2 11

5 6

S8

4 1

S3,4

2 1

S6,7

S8


1991 2006 1,29

1
62 51 7 4
11 5
1 5 62 130 8.6
1,2 117 6.1 11
111 3.9
1,2- 18 3.3

2011 12 6
5 1991
2011 0.0121
6 SMR 50095% 1801100
0.00204 SMR 290095%
11006400 6
2900

62 1,2- 5 31
SMR 64095%
2401400 410095% 1500
8800

1/6

3-2
33 22 S
11 50%
33 22

GTP 1182 IU/LALP 909 IU/LALT 144 IU/LAST 84 IU/L


2 GTP 783 IU/LALP 499 IU/L
ALT 53 IU/LAST 33 IU/L
6
S GTP 140 IU/L 45

1 S GTP 60 IU/L
10

1
1

.
1.
1-1
1)
U.S. NTP
2B6C3F 02,000 4,000 ppm F344/N
01,0002,000 4,000 ppm 1 6 5 102

0/500/4922/49 0/5023/48
21/48 22/5024/4933/49 3/5016/48
40/48U.S. NTP

2/501/504/50
5/50

-S-GST
3

P450CYP
GST
CYP
GST
S-
GST
GST 1
11

2) 1,2-
U.S. NTP 1,2-

4B6C3F 125250mg/kg/ F344/N 062125mg/kg/


0125250mg/kg/ 5 103

250 mg/kg/
U.S. NTP 1,2-

F344/DuCrj 1,2-
5

01252505001000 2000ppm 1 6 5
13 2000ppm 1000 2000ppm
GTP
2000ppm
080200 500ppm 1
6 5 104 500ppm GTP

B6D2F1/Crlj 1,2-
6
03280 200ppm 1 6 5
104
1,2-CYP GST
7

GST

1-2 GST
GST
GST 1
GST
3

GST

Sherratt 8
GST T1-1 GST
GST T1-1
GST
12

1,2-
GST

1-3
1)
4 2
1 9 19ppm 2 10
39ppm 0 1
1
2
3
11 3 140ppm
280ppm475ppm
4 12 2 50100ppm350700ppm
4 2
3 2 2

3 1954 1 1 1986 7 1
13
SMR 2095% 5.256
1990 12 11 SMR

2 SMR
4 12

2) 1,2-

AST
ALT
6

1-4 IARC
IARC 2B
1,2- 3
13

14
IARC 1

2A
2B

2.
2-1
1,2-46%
54% 1.7 L/h
60210 ppm 130360 ppm 1

S 1991 1992/93 1,2-


120430 ppm 80210 ppm1992/93 1997/98
100360 ppm 190540 ppm
1997/98 2006
1,2- 150670 ppm
GST 2001000
ppm 3
1991 1997/98

3 13
1,2-1997/98 2006
1,2-
GST

2-2

1
1,2-
40 ppm 90 ppm

3.
3-1

15, 16 4
14

15, 16

3-2
2005
2.61 /10 , 7.85 /10
75 3544 1/50
15, 17
S 1991 2006 1
62 SMR 290095% 1100
6400 1,2- 5 31
SMR 410095% 15008800

3-3

13
1,2-1991 2006 1,2-
100670ppm
GST
1,2- GST T1-1 GST T1-1

1 1,2-
13 12
1991 1997/98 80540ppm
GST
GST T1-1
2

12
15

1 CYP
18
1,2-
GST 1,2-

1,2-S

1997

.
S
1 1,2- 2
1,2-

16

.
1. .

A-2012-02

2012.
2. NTP (National Toxicology Program). Toxicology and carcinogenesis studies of dichloromethane
in F344/N rats and B6C3Fi mice (inhalation studies). NTP Technical Report 306, U.S. Dept.
Health and Human Services, Washington, DC. 1986.
3. .

Ver 1.1, No.15, .

2004.
4.

NTP

(National

Toxicology

Program).

Toxicology

and

carcinogenesis

studies

of

1,2-dichloropropane in F344/N rats and B6C3Fi mice (gavage studies). NTP Technical Report
263, U.S. Dept. Health and Human Services, Washington, DC. 1986.
5. Umeda Y, Matsumoto M, Aiso S, et al.

Inhalation carcinogenicity and toxicity of

1,2-dichloropropane in rats. Inhalation Toxicology 2010;22:1116-1126.


6. .

1,2-

, 0458. 2006.
7. . Ver 1.1, No.39, 1,2-
.

2004.

8. Sherratt PJ, Williams S, Foster J, Kernohan N, Green T, Hayes JD. Direct comparison of the
nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity.
Toxicol Appl Pharmacol 2002;179:89-97.
9. Tomenson JA. Update of a cohort mortality study of workers exposed to methylene chloride
employed at a plant producing cellulose triacetate film base. Int Arch Occup Environ Health
2011;84:889-897.
10. Hearne FT, Pifer JW. Mortality study of two overlapping cohorts of photographic film base
manufacturing employees exposed to methylene chloride.

J Occup Einviron Med

1999;41:1154-1169.
11. Lanes SF, Rothman KJ, Dreyer NA, Soden KJ. Mortality update of cellulose fiber production
workers.

Scand J Work Environ Health 1993;19:426-428.

12. Gibbs GW, Amsel J, Soden K. A cohort mortality study of cellulose triacetate-fiber workers
exposed to methylene chloride. J Occup Einviron Med 1996;38:693-697.
13. Lanes SF, Cohen A, Rothman KJ, Dreyer NA, Soden KJ.

Mortality of cellulose fiber

production workers. Scand J Work Environ Health 1990;16:247-251.


14. IARC (International Agency for Research on Cancer). List of Classifications by cancer sites
with sufficient or limited evidence in humans, Volumes 1 to 105. 2012. Available:
http://monographs.iarc.fr/ENG/Classification/Table4.pdf. [accessed 25 July 2012].
17

15. , .

2009:278-282.
16. , . 7, ,
1999:7-13.
17. , .

2006:322-330.
18. Bolt HM, Roos PH, Their R.

The cytochrome P-450 isoenzyme CYP2E1 in the biological

processing of industrial chemicals: consequences for occupational and environmental medicine.


Int Arch Occup Environ Health 2003;76: 174185

TEL 093-691-7288
shkumagai@health.uoeh-u.ac.jp

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