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EffectsofHPAcortisol onMetabolism
Inthefastedstate,cortisol stimulatesseveralprocessesthatcollectivelyserveto I th f t d t t ti l ti l t l th t ll ti l t increaseandmaintainnormalconcentrationsofglucoseinblood.Theseeffects include: Stimulationofhepaticgluconeogenesis,particularlyintheliver:
f fromnonhexose substratessuchasaminoacidsandlipids h bt t h i id d li id Enhancingtheexpressionofenzymesinvolvedingluconeogenesis
Mobilizationofaminoacidsfromproteinsextrahepatic tissues:for gluconeogenesis. Inhibitionofglucoseuptakeinmuscleandadiposetissue:glucoseconservation. Inhibition of glucose uptake in muscle and adipose tissue glucose conservation Stimulationoffatbreakdowninadiposetissue:
Thefattyacidsofenergy Glycerolforgluconeogenesis.