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Free fatty acid uptake and action in mammalian cellsA: serum free fatty acids (FFA) are generated

from lipoproteins by the action of endothelial lipoprotein lipase (LpL).

Doege H , Stahl A Physiology 2006;21:259-268


2006 by American Physiological Society

EffectsofHPAcortisol onMetabolism
Inthefastedstate,cortisol stimulatesseveralprocessesthatcollectivelyserveto I th f t d t t ti l ti l t l th t ll ti l t increaseandmaintainnormalconcentrationsofglucoseinblood.Theseeffects include: Stimulationofhepaticgluconeogenesis,particularlyintheliver:
f fromnonhexose substratessuchasaminoacidsandlipids h bt t h i id d li id Enhancingtheexpressionofenzymesinvolvedingluconeogenesis

Mobilizationofaminoacidsfromproteinsextrahepatic tissues:for gluconeogenesis. Inhibitionofglucoseuptakeinmuscleandadiposetissue:glucoseconservation. Inhibition of glucose uptake in muscle and adipose tissue glucose conservation Stimulationoffatbreakdowninadiposetissue:
Thefattyacidsofenergy Glycerolforgluconeogenesis.

EffectsonInflammationandImmuneFunction Eff t I fl ti dI F ti antiinflammatoryandimmunosuppressiveproperties.

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