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CD 68
XIIIa
Diagnosis: Xanthogranuloma
Comment: Intact epidermis with a diffuse dermal proliferation of large cells with angulated nuclei, abundant foamy cytoplasm, and well defined cell borders. The nuclei show inconspicuous nucleoli. Several multinucleated Touton-type giant cells ase seen.
The cytoplasm of the cells stain for CD 68 and Factor XIIIa, but not with S-100 and CD 1a. The lesion is most commonly seen in children, but it can occur at any age.
Diagnosis: Xanthogranuloma
Diagnosis: Xanthogranuloma
Diagnosis: Xanthogranuloma
Diagnosis: Xanthogranuloma
References
Necrobiotic Xanthogranuloma A Review of 17 Cases With Emphasis on Clinical and Pathologic Correlation Angela J. Wood, MD; M. Veronica Uraga Wagner, MD; Jared J. Abbott, MD, PhD; Lawrence E. Gibson, MD