Generic Name: acetaminophen (oral/rectal) Brand Names: Tylenol Dosage forms: 325,500,650; 120,160/5 mL; 500/15 mL; 325,650

supp pain, mild [325-1000 mg PO/PR q4-6h prn]Max: 1 g/4h and 4 g/day fever [325-1000 mg PO/PR q4-6h prn]Max: 1 g/4h and 4 g/day renal dosing [adjust dose frequency]CrCl 10-50: give q6h; CrCl <10: give q8h; HD/PD: no suppl ement hepatic dosing [not defined]hepatic impairment: consider decr. dose Mechanism of Action analgesic mechanism of action unknown; antipyretic effect via direct action on t he hypothalamic heat-regulating center Subclass:Other Analgesics Acetaminophen is a pain reliever and a fever reducer. Acetaminophen is used to treat many conditions such as headache, muscle aches, a rthritis, backache, toothaches, colds, and fevers Common Reactions nausea rash headache Serious Reactions anaphylactic/anaphylactoid rxns hepatotoxicity renal tubular necrosis, acute analgesic nephropathy, chronic anemia thrombocytopenia Contraindications/Cautions . hypersens. to drug/class/compon. caution if hepatic impairment caution if renal impairment (long-term use) caution if hypovolemia, severe caution if PKU (phenylalanine-containing forms) caution if malnutrition, chronic caution if chronic alcohol use Drug Interactions . Avoid/Use Alternative aspirin/ dipyridamole barbiturates carbamazepine CNS depressant/ aspirin/ caffeine combos

ethanol local anesthetics/ epinephrine opiate/ aspirin combos phenobarbital/ hyoscyamine/ atropine/ scopolamine rifampins