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Course Description (Note: General description in the form to be used for the Bulletin or Handbook should be attached) 1 Topics to be Covered List of Topics 1ABCD2ABCDProtein structure & Function: Amino acids. Structure of proteins Globular Proteins Fibrous Proteins Enzymes: Functions and Classification. Enzyme Kinetics. Regulation of Enzyme activity. Importance of Enzymes in clinical diagnosis. 3- Bioenergicts and oxidative phosphorylation 4- Carbohydrate metabolism: A- Introduction to carbohydrates. B- Glycolysis. C- Tricarboxylic acid cycle. D- Gluconeogenesis. E- Glycogen metabolism F- Metabolism of monosaccharides and disaccharides G- Pentose phosphate pathway and NADPH. H- Glycosaminoglycans and glycoproteins 5- Lipid metabolism. Metabolism of diatery lipids Fatty acids and triacyglycerol metabolism. Complex lipid metabolism. Cholesterol and steroid metabolism. 6- Nitrogen metabolism. Amino acids: Disposal of nitrogen. Amino acid degradation and synthesis Conversion of amino acids to specialized products. Disscussion of related clinical cases. 7- Integration of metabolism. Metabolic effects of insulin and glucagon. The feed/fast cycle. Diabetes mellitus. Obesity. Nutrition and vitamins. Nucleotide metabolism. Disscussion of related clinical cases. No Lect. Week Contact hours 1 1 1 1 1 1 1 1 3 1 2 2 2 2 2 2 2 4 4 4 4 3 3 3 3 1

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7- Storage and expression of genetic information. DNA structure and properties. RNA structure and properties DNA organization and replication. Transcription and RNA processing. Control of Transcription-procaryotes. DNA reapir. Protein Synthesis and the Genetic Code. Molecular tools of genetic diagnosis. Protein Mutations and Diseases. Disscussion of related clinical cases.

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