Renin-Angiotensin System

Beta Blockers

Liver
Angiotensinogen neutral endopeptidase Angiotensin I Angiotensin (1-7) Receptor 3 AT 3

Kininogens
Plasma Kallikrein BKB 2 Receptor Vasodilation , release of nitric oxide, prostacyclin, and endothelium derived hyperpolarizing factor, inhibition of platelet adhesion, and inhibition of smooth muscle proliferation.

Kidney
Big endothelin

Renin
Chymase

Bradykinin
Substance P

Endothelin I ACE Angiotensin Converting Enzyme

prolylendeptidase

Vasodilation & potentiate bradykinin

Capillary

Inhibition of

Adrenal Cortex Aldosterone

Metabolsim Angiotensin II Receptor Aldosterone Secretion Angiotensin II Receptor Blockers

Inactive Peptides

ACE Inhibitors Angiotensin II Receptor 1 AT 1

Angiotensin II

Systemic Vasoconstricition & expression of Plasminogen Activator Inhibitor-1 Angiotensin III Arginylaminopeptidase Glutamylaminopeptidase Angiotensin IV Angiotensin IV(3-8) Receptor 4 AT 4 Posterior pituitary Vasopressin release Angiotensin II Receptor 2 AT 2

Sodium resorption from the kidney distal kubules

Lumen Sodium Channel Na +

Learning and memory

Vasodialation & Apoptosis

Sodium Channel Modulators

Aldosterone Receptor