University of the Philippines

The Health Sciences Center

COLLEGE OF NURSING
Sotejo Hall, Pedro Gil Street, Manila

Drug Study

DRUG ORDER
(Generic
name, PHARMACOLOGI DESIRED NURSING
INDICATIONS AND ADVERSE EFFECTS OF
Dosage, C ACTION OF ACTION ON RESPONSIBILITIES
CONTRAINDICATIONS THE DRUG
Route, DRUG THE CLIENT /PRECAUTIONS
Frequency,
etc.)

Atenolol 50 Blocks beta- Indications Allergic reactions: • Monitor BP and

mg/tab 1 tab adrenergic • Treatment of Pharyngitis, erythematous pulse; not rate,
OD (p.o.) receptors of the angina pectoris rash, fever, sore throat, rhythm, quality
sympathetic due to coronary laryngospasm, respiratory • Check for
nervous system in atherosclerosis distress
baselines in
the heart and • Hypertension, as a CNS: Dizziness, vertigo,
renal and liver
juxtaglomerular step 1 agent, tinnitus, fatigue,
function tests
apparatus alone or with other emotional depression,
before therapy
(kidney), thus drugs, especially paresthesias, sleep
begins.
decreasing the diuretics disturbances,
• Assess edema in
excitability of the • Treatment of MI hallucinations,
heart, decreasing disorientation, memory feet, legs daily
cardiac output and • Unlabeled uses: loss, slurred speech • Monitor I&O,
oxygen Prevention of CV: Bradycardia, CHF, daily weight
consumption, migraine cardiac arrhythmias, • Check for JVD
decreasing the headaches; sinoatrial or AV nodal
release of renin alcohol withdrawal block, tachycardia, Precautions:
from the kidney, syndrome, peripheral vascular • Major surgery,
and lowering BP. treatment of insufficiency, claudication, lactation, DM,
ventricular and CVA, pulmonary edema, renal disease,
supraventricular hypotension thyroid disease,
arrhythmias. Dermatologic: Rash, CHF, COPD,
pruritus, sweating, dry asthma, well-
Contraindications skin compensated
EENT: Eye irritation, dry heart failure,
• Contraindicated eyes, conjunctivitis, dialysis,
with sinus blurred vision myasthenia
bradycardia, GI: Gastric pain, gravis
second- or third- flatulence, constipation,
degree heart diarrhea, nausea,
block, cardiogenic vomiting, anorexia,
 shock, CHF, ischemic colitis, renal and
pregnancy. mesenteric arterial
thrombosis,
retroperitoneal fibrosis,
hepatomegaly, acute
pancreatitis
GU: Impotence,
decreased libido,
Peyronie's disease,
dysuria, nocturia, frequent
urination
Musculoskeletal: Joint
pain, arthralgia, muscle
cramps
Respiratory:
Bronchospasm, dyspnea,
cough, bronchial
obstruction, nasal
stuffiness, rhinitis,
pharyngitis (less likely
than with propranolol)
Other: Decreased
exercise tolerance,
development of
antinuclear antibodies,
hyperglycemia or
hypoglycemia, elevated
serum transaminase,
alkaline phosphatase, and
LDH

Cefuroxime Inhibits bacterial Indications: CNS: Dizziness, • Assess patient

500mg/tab 1 wall synthesis, • Urinary tract headache, fatigue, for signs and
tab BID (p.o.) rendering cell wall infections, Otitis paresthesia, fever, chills, symptoms of
for 7 days osmotically media, confusion infection
unstable, leading • Severe infections GI: Diarrhea, nausea, • Assess for
to cell death by vomiting, anorexia, anaohylaxis:
binding to cell wall glossitis, bleeding, rash, urticaria,
Contraindications:
membrane increased AST, ALT, chills, fever,
• Sensitivity to
bilirubin, LDH, alkaline dyspnea
cephalosporins phosphatase, abdominal • Identify urine
pain, loose stools, output
flatulence, heartburn, • Assess bowel
stomach cramps, colitis,
pattern daily
jaundice
 GU: vaginitis, pruritus, • Monitor for
candidiasis, increased bleeding
BUN, nephrotoxicity, renal
failure, pyuria, dysuria,
reversible interstitial
nephritis
Simvastatin Inhibits HMG-CoA Indications CNS: Headache, asthenia, • Assess nutrition:
40mg/tab 1 reductase, the • Adjunct to diet in sleep disturbances fat, protein,
tab OD at hs enzyme that the treatment of GI: Flatulence, diarrhea, carbohydrates
(p.o.) catalyzes the first elevated total abdominal pain, • Monitor bowel
step in the cholestrol and LDL cramps, constipation, pattern daily
cholesterol cholesterol with nausea, dyspepsia, • Monitor
synthesis pathway, primary heartburn, liver failure triglycerides,
resulting in a hypercholesterole Respiratory: Sinusitis, cholesterol
decrease in serum mia (types IIa and pharyngitis baseline
cholesterol, serum IIb) in those Other: Rhabdomyolysis, throughout
LDLs, and either unresponsive to acute renal failure, treatment
an increase or no dietary restriction arthralgia, myalgia
change in serum of saturated fat Precautions:
HDLs. and cholesterol
• Past liver
and other
nonpharmacologic disease,
measures alcoholism,
severe acute
• To reduce the risk
infections,
of coronary
trauma, severe
disease, mortality,
metabolic
and CV events,
disorders,
including stroke,
electrolyte
TIA, MI and
imbalances,
reduction in need
elderly, renal
for bypass surgery
disease
and angionplasty
in patients with
coronary heart
disease and
hypercholesterole
mia
• Treatment of
patients with
isolated
hypertriglyceridem
ia
• Treatment of type
III
hyperlipoproteine
 mia
• Treatment of
adolescents 10-17
yr with
heterozygous
familial
hypercholesterole
mia

Contraindications

• Contraindicated
with allergy to
simvastatin,
fungal byproducts,
pregnancy,
lactation.

Norxifloxacin Interferes with Indications: CNS: headache, dizziness,  Assess patient

400mg/tab 1 conversion of • UTI, uncomplicated fatigue, somnolence, for previous
tab BID (p.o.) intermediate DNA gonorrhea depression, insomnia sensitivity
fragments into EENT: visual disturbances reaction
high-molecular Contraindications: GI: nausea, constipation,  Assess patient
weight DNA in • Hypersensitivity to decreased ALT, AST, for signs and
bacteria quinolones flatulence, heartburn, symptoms of
vomiting, diarrhea, dry infection, allergic
mouth reactions
INTEG: rash
 Monitor blood
studies
 Assess bowel
pattern daily