7/8/2012 6:52:00 PM MCQs 1.

Regarding the pharmacokinetics of Phenytoin, which is incorrect: a) It undergoes dose-dependent elimination b) Absorption is variable c) It is 10% bound to plasma proteins d) It has a half-life of 12 to 36 hours e) It can bind to thyroid binding globulin 2. Clinical uses of Valproate include the following, except: a) Absence seizures b) Generalised seizures c) Bipolar disorder d) Migraine prophylaxis e) Trigeminal neuralgia 3. Regarding Carbamazepine, which of the following is true: a) It is a hepatic enzyme inhibitor b) It can be given as a rapid IV bolus in status epilepticus c) It has a very fast systemic clearance d) It can be used in the treatment of bipolar disorder e) It is never used in the treatment of seizures 4. Which is NOT a side effect of Phenytoin: a) Nystagmus b) Ataxia c) Dry cough d) Gingival hyperplasia e) Agranulocytosis 5. Regarding Valproate, which is correct: a) It is a hepatic enzyme inducer b) It is 90% bound to plasma proteins c) Side effects are not dose related d) It has a large volume of distribution e) It is not very effective in the treatment of absence seizures

Answers: 1 c) 2 e) 3 d) 4 c) 5 b)

7/8/2012 6:52:00 PM

7/8/2012 6:52:00 PM