DRUG STUDY

Generic Name Brand Name Classificati on

Antifibrinolytic, antihemorrh agic

Mode of Action
Tranexamic acid is a synthetic derivative of the amino acid lysine. It exerts its antifibrinolytic effect through the reversible blockade of lysine-binding sites on plasminogen molecules. Anti-fibrinolytic drug inhibits endometrial plasminogen activator an d thus prevents fibrinolysis and the breakdown of blood clots. The plasminogenplasmin enzyme system is known to cause coagulation defects through lytic activity on fibrinogen, fibrin and other clotting factors. By inhibiting the action of plasmin (finronolysin) the anti-fibrinolytic agents reduce excessive breakdown of fibrin and effect physiological hemostasis.

Indication
Treating heavy menstrual bleeding Surgical: General surgical cases but most especially operative procedures on the prostate, uterus, thyroid, lungs, heart, ovaries, adrenals, kidneys, brain, tonsils, lymph nodes and soft tissues. Obstetrical and gynecological: abortion, post-partum hemorrhage and menometrorrahgia Medical: epistaxis, hemoptysis, hematuria, peptic ulcer with hemorrhage and blood dyscrasias with hemorrhage Effective in promoting hemostasis in traumatic injuries. .

Contraindication
Allergic reaction to the drug or hypersensitivity Presence of blood clots, or are at risk for blood clots Current administration of factor IX complex concentrates or antiinhibitor coagulant concentrates

Side Effects
Severe allergic reactions such as rash, hives, itching, dyspnea, tightness in the chest, swelling of the mouth, face, lips or tongue

Usual Dose
Tranexamc acid 15 mg/kg

Nursing Responsibilities
Observe 10rs () Double check the doctors order Identify client Explain must knows about the drug Give health education about side effects of the drug and stress to them to report any unusualities like: Unusual change in bleeding pattern For women who are taking Tranexamic acid to control heavy bleeding, the medication should only be taken during the menstrual period. The medication can be taken with or without meals. Swallow Tranexamic Acid whole with plenty of liquids. Do not break, crush, or chew before swallowing. If you miss a dose of Tranexamic Acid, take it when you remember, then take your next dose at least 6 hours later. Do not take 2 doses at once. Document all pertinent data

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H E M O S T A N