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  • MBBS Intracellular Signaling

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    Yash Tanwani
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    This document discusses intracellular signaling and signal transduction in cells. It describes how cells receive and respond to signals from their surroundings through molecular signaling between cells. There are different types of intercellular signaling including direct cell-cell contact and indirect signaling through secreted molecules. The stages of signal transduction are reception, transduction, and response. Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor, triggering intracellular changes along a signaling pathway and ultimately causing a specific cellular response. Various receptors are involved in signal transduction, including protein-coupled receptors, tyrosine and histidine kinases, integrins, and ligand-gated ion channels.

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    MBBS intracellular signaling

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    This document discusses intracellular signaling and signal transduction in cells. It describes how cells receive and respond to signals from their surroundings through molecular signaling between cells. There are different types of intercellular signaling including direct cell-cell contact and indirect signaling through secreted molecules. The stages of signal transduction are reception, transduction, and response. Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor, triggering intracellular changes along a signaling pathway and ultimately causing a specific cellular response. Various receptors are involved in signal transduction, including protein-coupled receptors, tyrosine and histidine kinases, integrins, and ligand-gated ion channels.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    13 views36 pages

    MBBS Intracellular Signaling

    Uploaded by

    Yash Tanwani
    This document discusses intracellular signaling and signal transduction in cells. It describes how cells receive and respond to signals from their surroundings through molecular signaling between cells. There are different types of intercellular signaling including direct cell-cell contact and indirect signaling through secreted molecules. The stages of signal transduction are reception, transduction, and response. Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor, triggering intracellular changes along a signaling pathway and ultimately causing a specific cellular response. Various receptors are involved in signal transduction, including protein-coupled receptors, tyrosine and histidine kinases, integrins, and ligand-gated ion channels.

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    of 36

    INTRACELLULAR SIGNALING

    DR. SYED ZARYAB AHMED

    CELL SIGNALING How do cells receive and res ond !o si"nals #ro$ !%eir s&rro&ndin"s. 'ro(ar)o!es and &nicell&lar e&(ar)o!es are lar"el) inde enden! and a&!ono$o&s. In $&l!icell&lar or"anis$s !%ere is a varie!) o# si"nalin" $olec&les !%a! are secre!ed or e* ressed on !%e cell s&r#ace o# one cell and +ind !o rece !ors e* ressed +) o!%er cells. T%ese $olec&les in!e"ra!e and coordina!e !%e #&nc!ions o# !%e cells !%a! $a(e & !%e or"anis$.

    des o# cell,cell si"nalin"

    -. Direc! cell,cell or cell,$a!ri* .in!e"rins and cad%erins/

    0. Indirec!1 Secre!ed $olec&les.

    A. Endocrine si"nalin". T%e si"nalin" $olec&les are %or$ones secre!ed endocrine cells and carried !%ro&"% !%e circ&la!ion s)s!e$ !o ac! on "e! cells a! dis!an! +od) si!es.

    C. 'aracrine si"nalin". T%e si"nalin" $olec&les released +) one cell on nei"%+orin" !ar"e! cells .ne&ro!rans$i!!ers/.

    E. A&!ocrine si"nalin". Cells res ond !o si"nalin" $olec&les !%a! !%e) $selves rod&ce .res onse o# !%e i$$&ne s)s!e$ !o #orei"n an!i"ens2 cancer cells/.

    THIS IS INTERCELLUL AR SIGNALING

    INTRACELLULAR SIGNALING
    3R SIGNAL TRANSDUCTI3N Signal transduction4occ&rs w%en an e*!racell&lar si"nalin"4$olec&le ac!iva!es a4cell s&r#ace rece !or. In !&rn2 !%is rece !or al!ers in!racell&lar $olec&les crea!in" a res onse.

    S!a"es o# Si"nal Transd&c!ion

    -. Rece !ion 5. Transd&c!ion 6. Res onse

    -. In rece !ion2 a c%e$ical si"nal +inds !o a cell&lar ro!ein2 !) icall) a! !%e cell7s s&r#ace. 5. In !ransd&c!ion2 +indin" leads !o a c%an"e in !%e rece !or !%a! !ri""ers a series o# c%an"es alon" a si"nal,!ransd&c!ion a!%wa) .sa) s!ar!in" wi!% #or$a!ion o# c)clic AM' !o ac!iva!ion o# (inases/. 0. In res onse2 !%e !ransd&ced si"nal .sa) (ind o# vario&s (inases/ !ri""ers a s eci#ic cell&lar ac!ivi!) .sa) cell elon"a!ion +) a&*in in lan!s/ . AM'LI8ICATI3N 38 SIGNAL CAN TA9E 'LACE . ITS LI9E A S:ITCH

    S!a"es o# Si"nal Transd&c!ion

    -. Rece !ion

    5a. Transd&c!ion

    S!a"es o# Si"nal Transd&c!ion

    5+. Transd&c!ion

    5c. Transd&c!ion

    5d. Transd&c!ion

    0. Res onse

    onses &s&all) involve increasin" or decreasin" so$e 'ro!ein7s 8&nc!

    RECE'T3RS IN;L3L;ED IN SIGNAL TRANSDUCTI3N


    E<TRACELLULAR

    G ro!ein,co& led 4T)rosine and %is!idine (inase 4In!e"rin 4Li"and,"a!ed ion c%annel

    INTRACELLULAR

    N&clear c)!o las$ic

    SEC3ND MESSENGERS

    E<TRACELLULAR
    G 'R3TEIN C3U'LED

    TYR3SINE AND HISTIDINE 9INASE


    INSULIN SIGNALING

    ADVANTAGES

    % cell is ro"ra$$ed !o res ond !o s eci#ic co$+ina!ions o# si"nalin" $o eren! cells can res ond di##eren!l) !o !%e sa$e c%e$ical si"nal.

    Molec&lar Biolo") o# !%e Cell2 5==5

    INTRACELLULAR RECE'T3RS
    STER3ID H3RM3NE 2 GLUC3C3RTIC3IDS THYR3ID H3RM3NE

    THAN X

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