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control
Siderophores
Pathogen
Antagonist
Mechanism of Action:
Competition-for nutrients, i.e. Iron
Siderophores
• Are the extra cellular, low molecular weight(500
to 1000 Daltons), virtually Fe III (ferric)-
specific legands produced as scavenging agent
in order to combat low iron stress.
• Iron chelating agents (Proteins)- make complex
with iron III with high affinity.
Most aerobic and facultative anaerobic
microorganisms respond to low iron stress by
producing siderophores.
On the basis of their chemical
structure:
• Two distinct type;
• Catecholate type: with catechol residue
• Hydroxymate type: with hydroxymic
acid residue
Other general charecteristics:
• They are also produced by some plants-
phytosiderophores
• Produced by one organism can be utilized by
another organism although there is great deal
of specificity in their uptake mechanism.
• Are utilized specifically i.e, the producer
organisms have special receptors for their
utilization.
• Condition of low iron solubility in soil, iron
chelators are extremely important for
mobilizing iron and increasing its availability
to plant and microbes.
• Operate in Gram-negative and Gram-
positive bacterial spp,
• Animal and plant pathogens,
• Aerobic bacteria and fungi,
• Symbiotic and free living nitrogen fixing
bacteria and others.
Microorganism Siderophores
A. Fungi
Aspergillus spp. Ferrichromes
&Penicillium spp.
.
Dwivedi&B.N.Johri
.
of groundnut-N.K.Arora,S.C.kang&D.K.Maheshwari