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  • Medimmune H1N1 Swine Flu Virus PATENT 2008

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    Tiffany Torres
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    19660910 Medimmune H1N1 Swine Flu Virus PATENT 2008[1]

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    299 views146 pages

    Medimmune H1N1 Swine Flu Virus PATENT 2008

    Uploaded by

    Tiffany Torres

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 146
    a9) 6 03) 3) ay @ (6) 2) Patent Application Publication United States ‘Yang et al. INFLUENZA HEMAGGLUTININ AND. NEURAMINIDASE VARIANTS Inventors: Chin-Fen Yang, San Jose, CA (US) George Kemble, Saratoga, CA (US); Kanta Subbarao, Washington, DC (US); Brlan Murphy. Bethesda, MD ws) Comespondence Address JOHNATHAN KLEIN-E) ‘ONE. MEDIMMUNE WAY GAITHERSBURG, MD 20878 (US) ANS Assignees: Medimmune Vaeeines, Ines, Gaiters: burg, MD (US); The Government of the United States of Ameriea National Institutes of Health, Rockville, MD (US) Appl. Nos 11836,413 Bile: Aug. 9, 2007 Related U.S. Application Data Provisional application No. 6(821:832, filed on Avg. 9, 2006, Provisional application No. 60042,804, fled oon Jun. 8, 2007, 'US 2008006982141 ao) Pub, No.: US 2008/0069821 Al (43) Pub. Date: Mar. 20, 2008 Publication Classification (1) Ine AGIK 39/145 (200601) AIK 357% (2006.01) 61K 39/00 (2006.01) AGIP 31/16 (2006.01) chan 119 (2006.01), CRN 1563 (2006.01) CRN 71 (2006.01), CRP 2100 (200601) CRN Sd (200601) CRN 121 (2006.01) COTK 1402006001) AGIK 39395 (2006.01) A6IK 39/12 (208601) I 424113941; 424/186.1; 424/206.1 4424/93,2; 435/235,1; 435/252.33 435/254.2; 435/325; 435/340: 435/350; 435/352; 435/364; 435/365; 435/69.3; 530/350 on ABSTRACT Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) infliazs hemagal- ‘inin and neuraminidase variants are provided. Patent Application Publication Mar. 20,2008 Sheet 1 of 31 US 2008/0069821 AI GGA TTA TTT Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe CCT CAA AGA GAG ACT CGA GGA TTA TIT Pro Gln Arg Glu Thr Arg Gly Leu Phe site of cleavage of into HA1 and HA2 domains. jues that were mutagenized are underlined. Fig 1. Patent Application Publication Mar. 20,2008 Sheet 2 of 31 US 2008/0069821 AI Virus isolation from swabs a Mortality Oro ! Cloacal Virus: (dead/total) pharyngeal detected/ ‘etal * # Mean logo shedding/ ,MECTUORC, shedding/ titer total 0) total (EID) 1997, 2008 ns a a are M5 0 ou | PONT wt 1987, 2008 cnt aor ore oe 09 ore 0.9 oe HEN ca Chickens were inoculated intranasally with 108 TCIDyq of virus, Fig 2.

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