Adopted Orphan Nuclear Receptors

PPAR (||)

LXR (Liver X Receptor) |
Cholesterol Sensor
Liver|Adipose|Kidney|Intestine|M
by: Cholesterol metabolites (Oxysterols)
Control cholesterol homeostasis
o Transport|Catabolism|Excretion
LXR & FXR work in concert to promote Cholesterol excretion

Green=FXR targets||Yellow=LXR targets
FXR (Farnesoid X Receptor)
Bile Acid Sensor
Liver|Intestine
by: Bile acids( cholic acid & deriv)
Control bile efflux|liver||excretion|intestine
o Solubilize lipids & vitamins
LXR cholesterol efflux from periph tissue & gets metabolized to bile in the
liver. The bile is then secreted into intestine for excretion.
FXR regulates bile metabolism in liver & the efflux from liver serves as
detergent for cholesterol secretion.
CAR (Constitutive Androstane Receptor)
by: phenobarbital
SXR (Steroid Xenobiotic Receptor)
Liver|Intestine
by: prescription Rx|steroids|toxins
CYP gene for P450
o CYP3A4 responsible for detox & CL of 60% of all prescription Rx
MDR gene
o Metabolite export