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  • MicroCards Ex 25

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    ridin007
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    S. aureus commonly causes skin infections like impetigo, cellulitis, and abscesses, as well as respiratory infections like pneumonia. It enters through breaks in the skin or respiratory tract. Virulence factors like protein A and coagulase help it evade the immune system. Untreated, it can spread through the bloodstream and cause endocarditis, meningitis, osteomyelitis or septic arthritis. Diagnosis is through blood cultures showing Gram-positive clusters that are catalase positive and coagulase positive. Treatment depends on whether the strain is methicillin-sensitive or resistant.

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    S. aureus commonly causes skin infections like impetigo, cellulitis, and abscesses, as well as respiratory infections like pneumonia. It enters through breaks in the skin or respiratory tract. Virulence factors like protein A and coagulase help it evade the immune system. Untreated, it can spread through the bloodstream and cause endocarditis, meningitis, osteomyelitis or septic arthritis. Diagnosis is through blood cultures showing Gram-positive clusters that are catalase positive and coagulase positive. Treatment depends on whether the strain is methicillin-sensitive or resistant.

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    13 views1 page

    MicroCards Ex 25

    Uploaded by

    ridin007
    S. aureus commonly causes skin infections like impetigo, cellulitis, and abscesses, as well as respiratory infections like pneumonia. It enters through breaks in the skin or respiratory tract. Virulence factors like protein A and coagulase help it evade the immune system. Untreated, it can spread through the bloodstream and cause endocarditis, meningitis, osteomyelitis or septic arthritis. Diagnosis is through blood cultures showing Gram-positive clusters that are catalase positive and coagulase positive. Treatment depends on whether the strain is methicillin-sensitive or resistant.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    CLINICAL PRESENTATION

    Local
    skin/subcutaneous: impetigo, cellulitis, folliculitis, furuncles, carbuncles
    respiratory: pneumonia with cavitations
    Systemic
    acute endocarditis, meningitis, osteomyelitis, septic arthritis
    PATHOBIOLOGY
    bacteria colonize skin (following breach) or nasopharynx (following intubation, viral respiratory infection) overgrow
    and evade host defenses using:
    protein A (binds Fc portion of IgG)
    coagulase (forms fibrin coat around organism)
    hemolysins, leukocidins (destroy RBCs and WBCs)
    neutrophils localize to infection site purulent abscesses form skin/subcutaneous infections or pneumonia
    bacteria may more deeply invade and reach bloodstream using:
    hyaluronidase (breaks down connective tissue)
    staphylokinase (lyses formed clots)
    lipase (breaks down fat)
    hematogenous spread to visceral organs systemic infection
    DIAGNOSIS
    blood culture positive: Gram clusters, catalase , coagulase
    TREATMENT
    antibiotic treatment:
    MSSA (methicillin-sensitive S. aureus): penicillinase-resistant penicillins
    MRSA (methicillin-resistant S. aureus): vancomycin
    QUICK FACTS
    Tricuspid valve endocarditis frequently affects IV drug users.
    Patients with chronic granulomatous disease (impaired neutrophil function) are vulnerable.
    S. aureus is a leading cause of osteomyelitis in children and adults.
    Staphylococcus aureus (infections)
    011-033_Harpavat_CoreCards_GramPosBacteria.indd 13b 7/10/11 1:15 AM

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