The document discusses the multiple fates of pyruvate in the body. Pyruvate can be converted into four different metabolites in one step: lactate, alanine, acetyl-CoA, and oxaloacetate. The conversion to acetyl-CoA via the pyruvate dehydrogenase complex requires four vitamin-derived cofactors. Pyruvate can also be routed to gluconeogenesis, fatty acid synthesis, or the TCA cycle for energy production. The conversion of pyruvate to oxaloacetate is a biotin-dependent reaction that provides substrate for the TCA cycle and gluconeogenesis.
The document discusses the multiple fates of pyruvate in the body. Pyruvate can be converted into four different metabolites in one step: lactate, alanine, acetyl-CoA, and oxaloacetate. The conversion to acetyl-CoA via the pyruvate dehydrogenase complex requires four vitamin-derived cofactors. Pyruvate can also be routed to gluconeogenesis, fatty acid synthesis, or the TCA cycle for energy production. The conversion of pyruvate to oxaloacetate is a biotin-dependent reaction that provides substrate for the TCA cycle and gluconeogenesis.
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The document discusses the multiple fates of pyruvate in the body. Pyruvate can be converted into four different metabolites in one step: lactate, alanine, acetyl-CoA, and oxaloacetate. The conversion to acetyl-CoA via the pyruvate dehydrogenase complex requires four vitamin-derived cofactors. Pyruvate can also be routed to gluconeogenesis, fatty acid synthesis, or the TCA cycle for energy production. The conversion of pyruvate to oxaloacetate is a biotin-dependent reaction that provides substrate for the TCA cycle and gluconeogenesis.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as PPT, PDF, TXT or read online from Scribd
College of Medicine King Saud Bin Abdulaziz University for Health Sciences Coenzymes are Needed for the Further Metabolism of Pyruvate
? • Which ones, and why? The Anaerobic Necessity
The production of pyruvate from glucose
requires the use of NAD+ Under anaerobic conditions, the resulting NADH cannot be oxidized by respiration Thus, other mechanisms must be employed to regenerate NAD+, if energy production from glycolysis is to continue Catabolic Fates of Pyruvate From Pyruvate to Acetyl-CoA
• Conversion from a 3-carbon unit to a 2-
carbon unit is achieved by • Oxidative decarboxylation of pyruvate by • The pyruvate dehydrogenase complex, • A cluster of 3 enzymes that • Requires 5 cofactors (4 of which are vitamin-derived) Carboxylation Of Pyruvate to Oxaloacetate • It is a biotin dependent reaction • It provides the substrate for TCA cycle Gluconeogenesis The TCA Cycle Pyruvate Carboxylase • Pyruvate – can be converted to four (4) different metabolites in one step = at a metabolic crossroads. – Lactate – by lactate dehydrogenase. – Alanine – alanine aminotransferase. – Acetyl CoA - pyruvate dehydrogenase. – Oxaloacetate – pyruvate carboxylase. • Pyruvate can also be routed toward: – Gluconeogenesis. – Free fatty acid synthesis. – TCA cycle for production of high energy P.