JRZ

Type of
Incompatibility
Category Remedy
PHYSICAL
INCOMPATIBILITY
Incomplete Solution
Silicone Water
Gums Alcohol
Resins Water
Terpin Hydrate* Simple syrup
Half of the syrup replaced w/ alcohol/isoalcoholic elixir (40%)
Low potency drug- Suspend w/ acacia/tragacanth/methocel
Phenobarbital elixir
10 ml of elixir replaced w/ alcohol- clear solution; requires +
40mg more of Phenobarb to obtain potency prescribed
Precipitation
Resins (from alcoholic
solutions)
Water
Mucilagenous &
Albuminous subs.,
metallic salts (from
aqueous solutions)
alcohol
Camphor & volatile oils
(salted out from
aromatic water)
Salts/ metals
Boric Acid (from a
solution)
Tragacanth
Colloidal solutions
(show pptation)
electrolytes
Camphor* (
salted out of the
saturated camphor
water)
electrolyte Dissolve bromide first in purified water, add camphor water
Resins/Benzoin
Compound* (soluble
only in high alcoholic
vehicles)
Rose water
Change in solvent system
Addition of the tincture with rapid stirring
Separation of
Immiscible Liquids
Oils in alcohol water
Ethyl nitrite spirit Potassium citrate
Chloral & alcohol*
(salted out)
Soluble bromides
Add water/alcohol (NaBr is insoluble in 50% alcohol)
Replace elixir with water & syrup or add sufficient water (about 1 oz)
to dilute the Rx below 10% alcohol
Liquefaction of Solid
Ingredients
Aminopyrine* ASA
Incorporate MgO/MgCO3 in each capsule
Add Diluent (divided between the reacting ingredients, these
combined with gentle trituration & the remainder of the ingredients

JRZ
incorporated.)
Another method of filling (allow the liquefaction to take place & then
absorb the liquid on sufficient kaolin or MgCO3 to give a suitable
capsule fill)

Camphor
monobromate*
Menthol
Dispense separately
Add adsorbent before mixing