List of Preclinical Services

www.liveonbiolabs.com
07/07/14 Liveon Biolabs Pvt. Ltd. CONFIDENTIAL


LIVEON BIOLABS PRIVATE LIMITED
Plot No.46 & 47, Water Tank Road, KIADB Industrial Area, Antharasanahalli, Tumkur 572106, Karnataka, INDIA. Ph.:9686904909

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LIST OF STUDIES

Sl.
No.
Type of Study Species Guideline
I. TOXICOLOGY TESTS/STUDIES
1 ACUTE ORAL TOXICITY Rats, Mice OECD 420 - Fixed Dose Procedure
2 ACUTE ORAL TOXICITY Rats, Mice OECD 423 - Acute Toxic Class
3 ACUTE ORAL TOXICITY Rats, Mice OECD 425 - Up and Down Method
4 ACUTE DERMAL TOXICITY Rats OECD 402
5 ACUTE EYE IRRITATION/CORROSION Rabbits OECD 405
6 REPEATED DOSE 28-DAY ORAL TOXICITY Rats, Mice OECD 407
7 REPEATED DOSE 90-DAY ORAL TOXICITY Rats, Mice OECD 408
8
COMBINED CHRONIC AND CARCINOGENICITY
STUDIES
Rats, Mice OECD
9
REPRODUCTION/DEVELOPMENTAL TOXICITY
SCREENING TEST
Rats/Rabbits OECD 421
10 ACUTE INTRAPERITONEAL TOXICITY Mice Principles of OECD 407
11 ACUTE INTRAMUSCUAR TOXICITY STUDIES Guinea Pigs WHO
LIVEON BIOLABS PRIVATE LIMITED
Plot No.46 & 47, Water Tank Road, KIADB Industrial Area, Antharasanahalli, Tumkur 572106, Karnataka, INDIA. Ph.:9686904909

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12 ACUTE SUBCUTANEOUS TOXICITY Mice WHO
13 FISH, ACUTE TOXICITY Fish OECD 203
14 ECO TOXICITY STUDIES
Aquatic Species/
Avian/Insects/
Earth worms etc.
Sponsor specified standard protocol
15 REPEATED DOSE 28-DAY OCULAR TOXICITY Rabbits Principles of OECD 407
16
REPEATED DOSE INTRAMUSCULAR TOXICITY
STUDY
Rabbits ICH and WHO
17 SKIN SENSITIZATION STUDIES Guinea Pigs Sponsor specified standard protocol
18 DOSE RANGE FINDING STUDIES Rats Principles of OECD 407
19 PHARMACOKINETIC TRIAL Rats, Mice, Rabbits Sponsor specified standard protocol
20
INVITRO & INVIVO GENOTOXICTY
MUTAGENEICTY TESTS: AMES ASSAY,
MICRONUCLEUS TEST
Rats, Mice OECD
II. DRUG TESTING TRIALS
1
BIOLOGICAL POTENCY
ESTIMATION/DETERMINATION/BIO-ASSAYS
Rats / Mice
British Pharmacopoeia (BP) / Indian
Pharmacopoeia (IP)/ European
Pharmacopoeia (EP)/ United States
Pharmacopoeia (USP)
2 ABNORMAL TOXICITY Mice
Indian Pharmacopoeia (IP)/ European
Pharmacopoeia (EP)/ United States
Pharmacopoeia (USP)
LIVEON BIOLABS PRIVATE LIMITED
Plot No.46 & 47, Water Tank Road, KIADB Industrial Area, Antharasanahalli, Tumkur 572106, Karnataka, INDIA. Ph.:9686904909

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3 PYROGEN TEST Rabbits
British Pharmacopoeia (BP) / Indian
Pharmacopoeia (IP)/ European
Pharmacopoeia (EP)/ United States
Pharmacopoeia (USP)
4 BIO-IDENTITY TEST Rabbits United States Pharmacopoeia (USP)
5 ERYTHROPOIETIN BIOASSAY Mice USP
6 INSULIN ASSAY Rabbits USP
III. EFFICACY TRIALS
1
EFFICACY STUDIES ON NUTRACEUTICAL
PRODUCTS
Rats/mice Sponsor specified standard protocol
2
OBESITY AND DIABETIC ANIMAL MODEL
DEVELOPMENT
Rats & Mice Sponsor specified standard protocol
3
COGNITION OR MEMORY ENHANCEMENT
TRIALS
Rats & Mice Sponsor specified standard protocol
4
ANTI-THROMBOCYTOPENIC DRUG EVALUATION
TESTS
Rats & Mice Sponsor specified standard protocol
5
EVALAUTION OF DRUGS AGAINST CHEMICAL
INDUCED HEPATOTOXICTY, NEPHROTOXICITY,
CARDIOTOXICITY, ULCERATION OF
GASTROINTETINAL TRACT
Rats & Mice Sponsor specified standard protocol
6 OTHER EFFICACY TRIALS
Rats, Mice, Rabbits,
G.Pigs
Sponsor specified standard protocol
7 IMMUNIZATION TRIALS Guinea Pigs Sponsor specified standard protocol
LIVEON BIOLABS PRIVATE LIMITED
Plot No.46 & 47, Water Tank Road, KIADB Industrial Area, Antharasanahalli, Tumkur 572106, Karnataka, INDIA. Ph.:9686904909

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8 IMMUNIZATION TRIALS Rats and Mice Sponsor specified standard protocol
9 IMMUNIZATION TRIALS Avian Sponsor specified standard protocol
IV. RESEARCH AND DEVELOPMENT TRIALS
1
PHARMACOKINETIC TRIAL IN JUGULAR VEIN
CANNULATED ANIMALS
Rats Sponsor specified standard protocol
Any other R & D customized trials as per requirements of clients
V. VETERINARY CONTRACT RESEARCH SERVICES
1 LARGE ANIMAL FIELD TRIALS Sheep, Goat, Cattle Sponsor specified standard protocol
2 POULTRY STUDIES
Chicks, broilers and
layers
Sponsor specified standard protocol