Tinjauan Pustaka

DISFUNGSI ENDOTEL PADA KANKER DAN INFEKSI DIKAITKAN

DENGAN GLYCOCALYX

Oleh:
M Rifqi Farizan Akbar
I1A008003

Pembimbing
dr. Hariadi, Sp.OG (K) Onk

BAGIAN ILMU KEBIDANAN DAN PENYAKIT KANDUNGAN

FK UNLAM RSUD ULIN
BANJARMASIN
Juni, 2014

DAFTAR ISI
Halaman
HALAMAN JUDUL ............................................................................................... i
DAFTAR ISI ........................................................................................................... ii
BAB I PENDAHULUAN ....................................................................................... 1
BAB II TINJAUAN PUSTAKA............................................................................. 5
2.1 Definisi ....................................................................................................... 5
2.2 Peran Glikokaliks Endotel Dalam Patofisiologi Penyakit ......................... 6
2.3 Komposisi Glycocalyx ............................................................................. 10
2.3.1 Komposisi Glycocalyx Endothelial Cells ................................ 10
2.3.2 Komposisi Glycocalyx Tumor ................................................. 12
2.4 Efek Glycocalyx Pada Penempelan CTC................................................. 14
2.5 Remodelling Glycocalyx Selama Inflamasi ............................................. 17
2.6 Efek Matrix Metalloproteinase Terhadap Perubahan Glycocalyx ........... 18
2.7 Respon Glycocalyx Terhadap Stress Gesekan Cairan ............................. 19
2.8 Efek Glycocalyx Pada Adhesi Leukosit................................................... 21
2.9 Efek Glycocalyx Pada Pengobatan Therapeutic Circulating Tumor Cells
(CTCs) ..................................................................................................... 23
2.9.1 Terapi Dengan Target CTC ..................................................... 23
2.9.2 Glycocalyx Sebagai Barrier Therapeutic ................................. 25
2.9.3 Terapi Tumor Yang Menargetkan Glycocalyx ....................... 27
BAB III PENUTUP .............................................................................................. 30
DAFTAR PUSTAKA

ii

iii