Phagocytosis

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Phagocytosis
Dr. Rabiul Haque
Lecturer,
Department of Pathology,
Holy Family Red Crescent Medical College , Dhaka

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Phagocytosis
Topics Overview:
-Definition
-Steps

of Phagocytosis
-Recognition & Attachment
-Engulfment
-Killing & Degradation
-Role of ROS
-Disease Associated With Defective
Phagocytosis

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Phagocytosis

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Phagocytosis
(phagein) , meaning "to devour"

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Phagocytosis
(phagein) , meaning "to devour"
, (kytos) , meaning "cell"

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Phagocytosis
(phagein) , meaning "to devour"
, (kytos) , meaning "cell"

osis, meaning "process"

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Phagocytosis
Cell-eating
Definition

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Phagocytosis
Cell-eating
Definition
The process of engulfment of solid
particulate material by the cells.

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Phagocytosis
Cell-eating
Definition
The process of engulfment of solid
particulate material by the cells.
Ref. Harsh Mohan - Textbook of Pathology, 6th Edition

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Phagocytosis
Phagocytes

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Phagocytosis
Phagocytes
Cells that performs Phagocytosis.

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Phagocytosis
Phagocytes
Cells that performs Phagocytosis.
-Polymorphonuclear

Neutrophils

-Macrophages

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Phagocytosis
Cell-eating

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Phagocytosis
Cell-eating

Pinocytosis
Cell-drinking

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Phagocytosis
Steps of Phagocytosis:

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Phagocytosis
Steps of Phagocytosis:
-Recognition

& Attachment

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Phagocytosis
Steps of Phagocytosis:
-Recognition

& Attachment

-Engulfment

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Phagocytosis
Steps of Phagocytosis:
-Recognition

& Attachment

-Engulfment

-Killing

& Degradation

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Recognition & Attachment

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Recognition & Attachment

-Mannose Receptors

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Recognition & Attachment

-Mannose Receptors
-Scavenger Receptors

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Recognition & Attachment

-Mannose Receptors
-Scavenger Receptors
-Receptors For Opsonins

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Recognition & Attachment

-Mannose Receptors
-Scavenger Receptors
-Receptors For Opsonins

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Engulfment

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Engulfment
-Receptor Initiated Signal Integration

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Engulfment
-Receptor Initiated Signal Integration
-Membrane Remodeling

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Engulfment
-Receptor Initiated Signal Integration
-Membrane Remodeling
-Cytoskeletal Changes

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Engulfment
-Receptor Initiated Signal Integration
-Membrane Remodeling
-Cytoskeletal Changes
-Ploymerization of Actin Filaments

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Engulfment
-Receptor Initiated Signal
Integration
-Membrane Remodeling
-Cytoskeletal Changes
-Ploymerization of Actin
Filaments

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Engulfment
-Receptor Initiated Signal
Integration
-Membrane Remodeling
-Cytoskeletal Changes
-Ploymerization of Actin
Filaments

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Killing & Degradation

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Killing & Degradation

Intracellular Mechanism

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Killing & Degradation

Intracellular Mechanism
Extracellular Mechanism

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Killing & Degradation

Intracellular Mechanism
-Oxidative Bactericidal Mechanism By Free Radicals
-Oxidative Bactericidal Mechanism By Lysosomal Granules
-Non-oxidative Bactericidal Mechanism
Extracellular Mechanism

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free

Radicals

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free

Radicals

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free

Radicals
- MPO Dependant

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free

Radicals
- MPO Dependant
- MPO Independent

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free

Radicals
- MPO Dependant
- MPO Independent

NADPH Oxidase

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Killing & Degradation

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free Radicals

MPO Independent Mechanism

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free Radicals

MPO Independent Mechanism

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Killing & Degradation

Oxidative Bactericidal Mechanism By Lysosomal
Granules

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Killing & Degradation

Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

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Killing & Degradation

Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

-Phospholipase

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Killing & Degradation

Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

-Phospholipase
-Trypsinase

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Killing & Degradation

Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

-Phospholipase
-Trypsinase

-Alkaline Phosphatase

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Killing & Degradation

Non-oxidative Bactericidal Mechanism

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Killing & Degradation

Non-oxidative Bactericidal Mechanism

Granules
-Lysosomal Hydrolase

-Defensins
-Lipase

-Protease
-DNAase, Permeability Increasing Factors
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Killing & Degradation

Non-oxidative Bactericidal Mechanism
Nitric Oxide
Peroxynitrite ( ONOO' )

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Killing & Degradation

Extracellular Mechanism

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Killing & Degradation

Extracellular Mechanism

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Frustrated Phagocytosis

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Diseases Due to Defective

Phagocytosis

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Diseases Due to Defective

Phagocytosis
-Chediak-Higashi Syndrome

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Diseases Due to Defective

Phagocytosis
-Chediak-Higashi Syndrome
-Chronic Granulomatous Disease

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Diseases Due to Defective

Phagocytosis
-Chediak-Higashi Syndrome
-Chronic Granulomatous Disease

-MPO Deficiency

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Phagocytosis

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