Student Name: Hour ate: Article of the Week Science Department ‘tcl Name: Include artee showing how you “dose read”. Remember underlining important pats, sie margin notes, connections to prevaus learning, We have done this n class, now show me what you can do. ‘+e¥0n the back ofthis paper write a DETAILED summary of ths article. This should be AT LEAST two 2 paragraphs." \What isthe main point the atl is trying to say to the reader? Explain in 12 sentences, Find one piece of data [Quarttative Data) from the article, copy i, and then expan is Importance. ‘What does this article meanto me and how can relate it to my Ife o to ther people's ves? How can | connect this article to something that have learned in science?What Scientists Have Learned From the Biggest Study On The Genetics Of Height <9 ) REUTERS By Will Dunham WASHINGTON (Reuters)- It's no secret that if your dad is tall and your mothers tall, you are probably going to be tall. But fully understanding the geneties of height has been a big, order for scientists. Researchers on Sunday unveiled what they called the biggest such study to date, analyzing senome data from more than a quarter million people to identity nearly 700 genetic variants and more than 400 genome regions relating to How tall or short a person becomes is estimated to be 8o percent genetic, with nutrition and other environmental faeters accounting for the rest. The world’s people on average have become taller over the past few generations because of factors including improved nutri “We study height for two main reasons,” said Dr. Joel Hirschhorn, a geneticist and pediatric endocrinologist at Boston Children's Hospital and the Broad Institute of Massachusetts Institute of Technology and Harvard University. “For over 100 years, it's been a great model for studying the genetics of diseases like obesity,diabetes, asthma that are also caused by the combined influence of many genes acting together. So by understanding how the geneties of height works, we ean understand how the genetics of human disease works,” he said In addition, short stature n childhood is a major clinical issue for pediatric endoerinologists. Knowing genes and their variants that are important for height eventually _may help doctors diagnose children who have a single major underlying cause for short stature, Hirschhorn addec. ‘The international team of esearchers analyzed data from the genomes of 253,288 people of European ancestry, all from Europe, North America and Australia. They perused about 2 million common genetic variants in these individuals and identified 697 gene variants in 424 gone regions as related to height. ‘Many genes pinpointed in the study, published in the journal Nature Geneties, are probably important regulators of skeletal growth, but were not previously known to be involved, the researchers said. Some were related to collagen, a component of bone; a component of cartilage called chondroitin sulfate; and growth plates, the area of growing tissue near the ends of the body's long bones ‘The researchers said there is much more to learn, “We've found the genetic variants - the pieces of DNA that vary from person to person - that account for 20 percent of the genetic component to normal variation in height said geneticist Timothy Frayling of Britain's University of Exeter. “This compares toa situation in 2007 when we knew absolutely nothing about the genes ‘and regions of the human genome involved in normal height differences despite everyone knowing height is very strongly genet ‘The team's previous 2010study involved a smaller number of people and identified 199 genetic variants residing in 180 genome regions. “By doubling the sample size, we doubled the number of gene regions that are connected to height, and greatly increased by about seven-fold the number of actual genes where we can ‘make a connection to the biology of normal skeletal growth,” Hirsehhiorn said. (Reporting by Will Dunhatn; editing by Susan Thomas)