Y O S I W. K U S U M A .

S G D B 0 1

MOTOR NEURON DISEASE

AND CURRENT
T R E AT M E N T

INTRO:

W H AT I S M O T O R N E U R O N
DISEASE?

(Ice Bucket Challenge)

IT IS ALS

A L SO K N O W N A S LOU GE H R I G D I S E A SE

A M Y O T R O P H I C L AT E R A L
S C L E R O S I S (What We Know)

It is a

progressive motor disease

Progress within 1-5 years

Death is usually by respiratory paralysis

E P I D E M I O LO GY

Men are twice as likely to be effected

1-3 per 100.000 incidence

And a high prevalence in the western Pacific region (Guam

and Papua New guinea)

ALS DOES NOT EFFECT

I T O N LY E F F E C T S T H E

THE MUSCLE TONE BECOME

THE COGNITIVE SKILL

MOTOR SKILL

THIN

AND

WEAK

First sign of ALS is developing asymmetric weeks,

especially in the distal limbs. And it is asymmetric
Then there is difficulty in the facial muscle movement
Over time, more and more muscle became
involved until the disorder is symmetric and
effects all regions

HOW DO WE DIAGNOSE?
ALS is definite if 3 or 4 of the following motor neuron is involved

Bulbar
Cervical
Thoracic
Lumbosacral

W H AT C A U S E A L S ?

mostly it is cause by the defect of the SOD1 gene,

that function as a peroxides and antioxidants

And for treatment?

THERE IS

N O K N O W N T R E AT M E N T

There is only treatment to lengthen the survival

Only Riluzole can help patient with ALS

But the spesific mechanism isn't clear yet

Some research suggest that the treatment effects the

glutamate release concentration of the body

What Can We Do?

Donate, donate and donate

to further research on ALS

Every life is a good life.

Y. W. K .