GIANT CELL LESIONS OF JAWS

Guided By :Dr. Vimal Kalia

Presented By :Dr. Ravish Malhotra

Prof. & H.O.D.

P.G. 2 ND Year

Deptt. Of Oral & Maxillofacial Surgery

BRS Dental College & Hospital

Cells those are larger in size than normal size of cell are called as giant cells.

These contain more than one nucleoli and are called as multinucleated giant
cells.

These cells are found in many physiological and pathological conditions.

Physiological conditions:

Resorption of deciduous teeth

Healing of extraction of teeth

Orthodontic tooth movement

Synctiotrophoblasts of placenta

CLASSIFICATION

1) Damaged striated muscle fibers:

Regenerating sarcolemmal cells in damaged voluntary muscle
Aschoff giant cell in heart muscle (in rheumatic fever)

2) Fused fibroblasts: giant cell fibroma

3) Osteoblasts in bone resorption

4) Tumor giant cells: These are the large tumor cells with single huge polymorphic
nucleus having two or more nuclei. These nuclei are hyper chromatic and very large
compare to size of cell.

Eg. Reed-Steinberg giant cells in Hodgkins lymphoma,

Giant cell in central giant cell granuloma,

Poorly differentiated astrocytoma

Giant cell in the tumors like carcinoma.

5) Inflammatory giant cells: Like foreign body giant cells or Langerhans giant
cells they have normochromic small normal nuclei, but numerous within one
cell.

6) Fused cell due to viral infection:

Epithelial giant cell as in HSV infection

Connective tissue cells as in Meseals Warthin Finkeday cells

7) Fused macrophages:

Due to reaction of foreign body ( exogenous and endogenous material

Due to reaction of organisms as in TB (Langerhans giant cell) and fungal
infection
Touton giant cell of xanthoma.