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If you have completed a first-year high school biology course, some of this
chapter will serve as a review for the basic concepts of Mendelian genetics.
For other students, this may be your first exposure to genetics. In either
case, this is a chapter that should be carefully mastered. Spending some time with
this chapter, especially working genetics problems, will give you a solid foundation
for the extensive genetics unit in the chapters to come.
Overview:
1.
Concept 14.1 Mendel used the scientific approach to identify two laws
of inheritance
2.
One of the keys to success for Mendel was using pea plants. Explain how
using pea plants allowed Mendel to control mating; that is, how did this
approach let Mendel be positive about the exact characteristics of each
parent?
3.
Define the following terms. Then, consider your own
generation would your Moms grandparents be? Your Mom? You?
family.
Which
Explain how Mendels simple cross of purple and white flowers did the following:
The first concept is that alternative versions of genes account for variations in
inherited characters
For example, the gene for flower color in pea plants exists in two versions, one
for purple flowers and the other for white flowers
These alternative versions of a gene are now called alleles
6.
On the figure at below, label the allele for both purple and white flower
color, a homologous pair, and the locus of the flower color gene.
7.
3rd Concept
4th Concept
Law of
Segregation
9.
Using Figure 14.5 as your guide, provide the missing notations for the figure
In pea plants, T is the allele for tall plants, while t is the allele for dwarf
plants. If you have a tall plant, demonstrate with a test cross how could it
be determined if the plant is homozygous tall or heterozygous tall.
Such an individual must have one dominant allele, but the individual could be
either homozygous dominant or heterozygous
10.
The answer is to carry out a testcross: breeding the mystery individual with a
homozygous recessive individual
If any offspring display the recessive phenotype, the mystery parent must be
heterozygous
Mendel identified his second law of inheritance by following two characters at the
same time
Crossing two true-breeding parents differing in two characters produces dihybrids
in the F1 generation, heterozygous for both characters
A dihybrid cross, a cross between F1 dihybrids, can determine whether two
characters are transmitted to offspring as a package or independently
12.
As you start to work word problems in genetics, two things are critical: the
parents genotype must be correct, and the gametes must be formed
correctly. Using Figure 14.8 as your guide, explain how the gametes are
derived for the following cross. (You should have four different gametes).
YyRr YyRr
YR Yr Ry ry
13.
14.
What is the probability that a couple will have a girl, a boy, a girl, and
a boy in this specific order?
Concept 14.3 Inheritance patterns are often more complex than those predicted by
simple Mendelian genetics
Explain how incomplete dominance is different from complete
dominance, and give an example of incomplete dominance.
In incomplete dominance, the phenotype of F1 hybrids is somewhere
between the phenotypes of the two parental varieties
20.
Dominant alleles are not necessarily more common than recessive alleles in
the gene pool.
Explain why this is true.
A dominant allele does not subdue a recessive allele; alleles dont interact
Alleles are simply variations in a genes nucleotide sequence
For any character, dominance/recessiveness relationships of alleles depend
on the level at which we examine the phenotype
23. Explain what is meant when a gene is said to have multiple alleles.
Most genes exist in populations in more than two allelic forms
For example, the four phenotypes of the ABO blood group in humans are
determined by three alleles for the enzyme (I) that attaches A or B carbohydrates
to red blood cells: IA, IB, and i.
The enzyme encoded by the IA allele adds the A carbohydrate, whereas the
enzyme encoded by the IB allele adds the B carbohydrate; the enzyme encoded by
the i allele adds neither
24.
Blood groups are so important medically that you should be able to solve
genetics problems based on blood types. The first step in accomplishing
that is to understand the genotypes of each blood type. Before working
any problems, complete this ABO blood type chart.
Genotype
A A
I I or I i
IBIB or IBi
IAIB
ii
Red
See
See
See
See
25.
Explain why the dihybrid cross detailed in Figure 14.12 has 4 white mice
instead of the 3 that would have been predicted by Mendels work.
33.
Explain why you know the genotype of one female in the third generation, but
are unsure of the other. The F3 generation was not followed in this pedigree.
34.
35.
Amniocentesis and chorionic villus sampling are the two most widely used
methods for testing a fetus for genetic disorders. Use the unlabeled
diagram below to explain the three main steps in amniocentesis and the
two main steps of CVS.
37. What are the strengths and weaknesses of each fetal test?
In amniocentesis, the liquid that bathes the fetus is removed and tested,
DAMAGING, weeks long to find results.
In chorionic villus sampling (CVS), a sample of the placenta is removed and tested,
DAMAGING, several hours to find results
Other techniques, such as ultrasound and fetoscopy, allow fetal health to be
assessed visually in utero, NOT DAMAGING, observation is instant
Explain the symptoms of phenylketonuria, and describe how newborn
screening is used to identify children with this disorder.
The damage caused by PKU can begin weeks after the baby has started drinking
breast milk or formula. Babies with PKU need foods low in phenylalanine to
38.
prevent severe brain damage. Phenylalanine is found in most foods that have
protein, such as milk, cheese, and meats.
A phenylketonuria (PKU) test is done to check whether a newborn baby has the
enzyme needed to use phenylalanine in his or her body. Phenylalanine is an
amino acid that is needed for normal growth and development. If a baby's
body does not have the enzyme that changes phenylalanine into another
amino acid called tyrosine, the phenylalanine level builds up in the baby's
blood and can cause brain damage, seizures, and intellectual disability.
Some genetic disorders can be detected at birth by simple tests that are now
routinely performed in most hospitals in the United States
This chapter does not have a Self-Quiz, but rather asks you to do a series of
problems. One of the ways to determine your understanding of Mendelian genetics
is to work many genetic problems. Complete the questions from the problems at
the end of the chapter.
Before starting, it would be productive to read the Tips for Genetic Problems
on page 283. Work neatly, and show all work. As you know, you can check your
solutions in your text. Questions: Read and find 2, 3, 5, 6, 7, 8, and 9 below; Do
1, 13, 16, 17, and 19.
2.
3.
5.
6.
7.
8.
9.