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com/user/DrRabiulHaque

Dr. Rabiul Haque

Lecturer,
Department of Pathology,
Holy Family Red Crescent Medical College,
Dhaka

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Definition of Free Radical

Examples of Free Radicals
How Free Radicals Are Generated
How Free Radicals Are Removed
How Free Radicals Cause Cell Injury

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Definition of Free
Radicals

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Definition of Free
Free radicals are chemical species that
Radicals

contain single unpaired electron in an outer

orbit.

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Definition of Free
Free radicals are chemical species that
Radicals

contain single unpaired electron in an outer

orbit.

Ref. Robbins & Cortan Pathologic Basis Of Disease 9th

Edition

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Stay Calm And Look At Teddy !

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Free Radicals
Definition:
Free
radicals
are
chemical species that
contain single unpaired
electron in an outer
orbit.

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Free Radicals
Definition:
Free
radicals
are
chemical species that
contain single unpaired
electron in an outer
orbit.
Unstable
reactive

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&

highly

Free Radicals
Definition:
Free
radicals
are
chemical species that
contain single unpaired
electron in an outer
orbit.
Unstable
&
highly
reactive
Autocatalytic Reaction
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Free Radicals
Definition:
Free
radicals
are
chemical species that
contain single unpaired
electron in an outer
orbit.
Unstable
&
highly
reactive
Autocatalytic Reaction
Induce cell injury
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Free Radicals
Definition:
Free
radicals
are
chemical species that
contain single unpaired
electron in an outer
orbit.

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Unstable
&
highly
reactive
Autocatalytic Reaction
Induce cell injury
Has role in phagocytosis

Stay Calm & Look At

Teddy !!

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Examples of Free
Radicals

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2
Hydrogen Peroxide

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2

Hydrogen Peroxide H2O2

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2

Hydrogen Peroxide H2O2

Hydroxyl Radical

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2

Hydrogen Peroxide H2O2

Hydroxyl Radical HO

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2

Hydrogen Peroxide H2O2

Hydroxyl Radical HO

NO ( Nitric Oxide )

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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2

Hydrogen Peroxide H2O2

Hydroxyl Radical HO

NO ( Nitric Oxide )
ONOO ( Peroxynitrite Anion )
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Examples of Free
ROS ( Reactive Oxygen Species)
Radicals
Superoxide Anion O2
Hydrogen Peroxide H2O2
Hydroxyl Radical HO

NO ( Nitric Oxide )
ONOO ( Peroxynitrite Anion )
NO2, NO3
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How Free Radicals Are

Generated ?

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Oxidation = Loss of electron
Reduction = Gain of electron

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation

NADPH Oxidase

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation

NADPH Oxidase
Xanthine Oxidase

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation
During Enzymatic Metabolism of Exogenous
Chemicals and Drugs

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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation
During Enzymatic Metabolism of Exogenous
Chemicals and Drugs
Transition Metals
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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation
During Enzymatic Metabolism of Exogenous
Chemicals and Drugs
Transition Metals
Fenton Reaction
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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during
normal metabolic processes
Absorption of Radiant Energy
During Inflammation
During Enzymatic Metabolism of Exogenous
Chemicals and Drugs
Transition Metals
Fenton Reaction : Fe2++ H2O2 Fe3++ HO + OH
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How Free Radicals Are

Generated
?
By Reduction-Oxidation
Reactions during

normal metabolic processes

Absorption of Radiant Energy
During Inflammation
During Enzymatic Metabolism of Exogenous
Chemicals and Drugs
Transition Metals
NO generated by endothelial cells, neurons,
macrophages etc. combines with superoxide and
forms peroxynitrate (ONOO )
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How Free Radicals Are

Removed ?

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How Free Radicals Are

Removed
Antioxidants ?

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione
Binding Transition Metals With Storage And

Transport Proteins

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione
Binding Transition Metals With Storage And

Transport Proteins
By Free Radical Scavenging System

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione
Binding Transition Metals With Storage And

Transport Proteins
By Free Radical Scavenging System
Catalase

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione
Binding Transition Metals With Storage And

Transport Proteins
By Free Radical Scavenging System
Catalase
Superoxidase dismutases

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione
Binding Transition Metals With Storage And

Transport Proteins
By Free Radical Scavenging System
Catalase
Superoxidase dismutases
Glutathione peroxidase

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How Free Radicals Are

Removed
?
Antioxidants: Vitamin
A, C, E and Glutathione
Binding Transition Metals With Storage And

Transport Proteins
By Free Radical Scavenging System
Catalase : 2H2O2 O2 + 2H2O
Superoxidase dismutases
Glutathione peroxidase :
H2O2 + 2GSH GSSG+ 2H2O
2OH + 2GSH GSSG + 2H2O
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Effects of Free Radicals

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Effects of Free Radicals

Lipid Peroxidation of Membranes

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Effects of Free Radicals

Lipid Peroxidation of Membranes
DNA Damage

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Effects of Free Radicals

Lipid Peroxidation of Membranes
Oxidative Modification of Protein
DNA Damage

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Effects of Free Radicals

Lipid Peroxidation of Membranes
Oxidative Modification of Protein
DNA Damage

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Effects of Free Radicals

Lipid Peroxidation of Membranes
Oxidative Modification of Protein
DNA Damage

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Effects of Free Radicals

Lipid Peroxidation of Membranes
Oxidative Modification of Protein
DNA Damage

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Thank you for watching this

video !

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Thank you for watching this

video
! this video do comment, share,
If you like
subscribe and let me know.

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Thank you for watching this

video
! this video do comment, share,
If you like
subscribe and let me know.
Best wishes from Bangladesh .

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