39

five half lives:

1s
1h
24 h

36

energy barrier (kcal/mol)

33
30
27
24
21
18
15
12
9
-75

-50

-25

25

50

75

100

temperature (C)

125

150

175

200

64

barrier
(kcal/mol)
10
15
20
25
30
35

35 kcal/mol

speedup

32

16

10 kcal/mol
1
200

250

300

temperature (C)

350

400

high ksolv
lower E

normal region:
less reactive,
more selective
low ksolv
higher E

vertical slope:
constant selectivity

negative slope:
more reactive,
more selective!