SARDAR PATEL UNIVERSITY

Programme & Subject: M.Sc (Organic Chemistry)

Semester: IV
Title of Paper: Medicinal Chemistry

Sr.
Unit Name
Study Material
1 Introduction to Medicinal Chemistry,
1) Burgers Medicinal Chemistry and Drug
Pharmacokinetics:
Discovery (P: 20-39)
Drug absorption, drug distribution, drug
Metabolism (general pathway of drug metabolism:
Oxidative, reductive and hydrolytic reactions)
2) Essential of Medicinal Chemistry
Drug Design:
(P:120-150)
Concepts pf drug design, Approaches to lead
discovery, SAR, Combinatorial chemistry,
Prodrugs. Drug excretion. Drug administration.
2 Pharmacodynamics:
Medicinal Chemistry 3rd Edition by
Receptors, Chemical messengers, Binding sites,
Ashutosh Kar (p: 02 - 60)
Receptor types and
subtypes(protein receptors, DNA receptors with
examples of Agonists and Antagonists)
3 Psychoactive Drugs:
Antianxiety agents, Antipsychotics,
Medicinal Chemistry 3rd Edition by
Antidepressants, Psychotomimetic drugs.
Ashutosh Kar (p: 02-60)
Cardiovascular Drugs:
Antianginal and Vasodilators, Antihypertensive
drugs, Anticholesterolemic agents Antithyroid drugs
4 Antibiotics:
General Introduction, Chemical Classification.
1) Medicinal Chemistry 3rd Edition by
-lactam antibiotics:
Ashutosh Kar (p:794-832)
Penicillins, Cephalosporins, -lactamase inhibitors,
2) Burgers Medicinal Chemistry and
Aminoglycosides,Tetracyclines,
Drug Discovery (p: 10-79)
Chloramphenicol ,Quinolone antibacterials.
Antineoplastics Agents: Classification,synthesis
and drug profile.
Subject taught by Dr.Rajarshi N Patel & Mr.Dharam M. Pandya

Paper Code: PS04ECHE01