X471 INTRODUCTION TO BIOSTATISTICS UC BERKELEY EXTENSION (SF DOWNTOWN CENTER) SPRING 2013 LECTURE: TUESDAY, 6:30 - 9:30 PM, SF DOWNTOWN CAMPUS, ROOM 810. INSTRUCTOR: Dr. Steven E. Kelley EMAIL: skelley@unex.berkeley.edu IRSE DE: IPTION: The health and behavioral sciences commonly use several statistical methods (linear regression, ANOVA, logistical regression, and nonparametric methods) to study biological problems. This course is designed to assist you to gain the statistical skills to read scientific articles in your fields, understand the statistical methods used, and interpret the results on your own. As importantly, we will use a “hands-on” approact to learn how to design experiments, gather data, and analyze re: sults for presentatior Learn to use computers and software for statistical analysis. This course is designed for premedical students and professionals who are interested in biostatistics. Prerequisites: Basic mathematics skills and computer literacy At the completion of the course, students will be able to: Calculate summary statistics Calculate common probability distributions and apply those calculations to solve problems based on biological and medical studies Calculate the distribution of observations about the mean based on assumptions of normality and apply those calculations to solve problen based on biological and health-related data Calculate the distribution of sample means about the mean and apply those calculations to solve problems based on biological and health related data Compare two means (from paired and unpaired data) using both parametric and nonparametric methods and use those methods to tes hypotheses Analyze categorical data Compare more than two means using analysis of variance methods an use those methods to test hypotheses derived from both single factc and two factor experimental designs Calculate least squares regression lines and apply those calculations t solve problems based on biological and health-related studiesB. TIVE; This course will provide you with a working knowledge of biostatistics, through lectures, problem sets, and data analysis. From my personal experience, | have found that a hands-on approach is much more effective for learning and retaining statistical skills. Hence, we will collect most of the data that we will analyze. Overall, we will cover the principles of experimental design, data analysis and presentation. The ultimate goal is to prepare you to conduct your own research project, data anal which you will present to the class in and end-of-semester symposium, REQUIRED TEXTS: Statistics for the Life Sciences. Myra L. Samuels and Jeffrey Witmer. 3 edition, 2003. ISBN 13: 978-0130413161 (THERE IS A 4™ EDITION). PRENTICE HALL, ISBN 13: 978-0321652805. EITHER WILL SUFFICE. ysis, JMP Start Statistics: A Guide to Statistics and Data Analysis Using JMP. 2007. Fourth Edition. John Sall, Lee Creighton, and Ann Lehman. ISBN: 978-S994 572-9. JMP can be ordered online: bttp://www,onthehub.com/jmp/. Wait till the last month and you can get a free trial for 30 days. GRADING: Exams: There will be 2 exams (ONE midterm hour exam and a FINAL exam), The exams will not be cumulative, though we will continue building on the material learned earlier in the course. The focus of the course is the completion of an individual research project, for which you will use many of the skills obtained throughout the semester. The grading options for courses numbered X400-499 are as follows: CLG—Credit Letter Grade (DEFAULT STUDENT GRADING OPTION) P/NP—Pass/Not Pass NC—Not for Credit W—wWithdrawal (must be student-initiated) Please note that auditing is not permitted in UC Berkeley Extension courses, Students who wish to attend the course but who do not wish to take a course for Credit Letter Grade (CLG) need to pay to enroll as Not for Credit (NC). Letter grade assignments: are shown on the last page. Project: There will be one final project, which will require that you obtain your ). You will analyze your results, create ent them orally to the class using own data (from observations or an experiment. inted and turned in to me prior to figures and tables, draw your conclusions, and pres Powerpoint. The Powerpoint presentation will be pri the oral presentation. If needed or desired, | will provide training in seminar presentation and organization, prior to your talk.ee will be a regular and important feature of graded, but not haere nave competed the homework on time. Hom The hotreaonet harshly. tis OK to make mistakes. Its importan ay * you will get most points for the serious attemy Ing the right answer. Making mistakes is how you will learn. enough how critical homework is to gaining an understanding of cl for doing well on exams. There is no substitute for attempting to do the h on your own, prior to class. Simply copying down answers does not work don’t practice doing problems, when you get to the exam, you will not by solve the problems. will ch Participation: You are strongly encouraged to participate and to ask q If you have questions while | am lecturing, feel free to raise your hand. | wil things as often as necessary for the majority of students to catch on. If you individual attention for any reason, feel free to schedule an appointment. The following weightings will be used to determine the final grade: MIDTERM EXAM (6-2 proele ms ) 25% _ ae <2 /estanEINAL EXAM 30% {not om / +8 ENAL PROJECT 25% HOMEWORK 15% 5% CLASS PARTICIPATION LECTURE SCHEDULE: READING # DATE TOPIC 1 JANIS COURSE INTRO swi DESCRIBING POPULATIONS Sw2 2 JAN 22 RANDOM SAMPLING/THE BINOMIAL DISTRIBUTION Sw3 3 JAN 29 THE NORMAL DISTRIBUTION sw4 4 FEBS. SAMPLING DISTRIBUTIONS sws 2 FEB 12 CONFIDENCE INTERVALS Sswé 6 FEB 19 COMPARISON OF TWO INDEPENDENT SAMPLES SW7 T FEB 26 MIDTERM EXAM 8 MAR 5 PRINCIPLES OF DESIGN sws io: MAR 12 COMPARISON OF PAIRED SAMPLES. sw 10 MAR19 CATEGORICAL DATA: X2-SQUARE TEST FISHER EXACT SW 10 11. MAR 26 COMPARISON OF MANY SAMPLE MEANS. swii 12 APR2 LINEAR/MULTIPLE REGRESSION AND CORRELATION SW 12 13. APRO REVIEW AND SPECIAL TOPICS (cate ued 14. APR16 PROJECT PRESENTATIONS lowwinS 15 __APR23 FINAL EXAMGrades are assigned on the following basis per UC Berkeley extension policy: GRAD GRA RECOMMEND DESCRIPTION E (FOR ROSTE R) At A A Bt B B- C+ c DE POIN TS PER UNIT 4.0 4.0 S74 3.3 3.0 oF 2.3 2.0 ED PERCENTAGE BREAKDOWN 94-100% 94-100% 90-93% 86-89% 83-85% 80-82% 76-79% 73-75% 70-72% 66-69% 63-65% 60-62% < 60% Excellent: The grade of "A+", when awarded at the instruct discretion, represents extraordinary achievement, but does receive grade point credit beyond that received for the gra A. Good Fair: Each course in a certificate program must be complet with a grade of C or better, although some programs have requirements. Barely passed Failed Passed at a minimum level of C-minus or 70% Not Passed—anything below a C-minus or below 70% Satisfactory or passed at a minimum level of B-minus or (only an option for graduate division university courses « 200-299) Unsatisfactory—anything belov an option for graduate division university courses, e.g. » 2) > eats ser AAO.