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PATHOPHYSIOLOGY

HYPOTHYROIDISM

CAUSES

PRIMARY
CONGENITAL

Thyroid dysgenesis
Thyroid hormone resistance
syndrome
Congenital dyshormogenetic
goiter

ACQUIRED

Postablative
Iodine deficiency
Drugs

AUTOIMMUNE

SECONDARY
Pituitary failure
Thalamic failure

CONGENITAL HYPOTHYROIDISM
CONGENITAL

Cold Intolerance
Short Stature
Slow Mental &
Physical
Developmement
Puffy Face

Thyroid dysgenesis
Thyroid hormone resistance
syndrome
Congenital dyshormogenetic
goiter

Deficient Thyroid
Hormone
Increased TSH level,
Increased TRH

Gonadal Stimulation
Breast Development: Tanner
Stage 2-3
Bilateral Ovarian
Enlargement
Multicystic Ovaries
Uterine Bleeding

Hyperprolactine
mia

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