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  • 223.20 Principles of Cell Signaling2015

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    Abhishek Isaac Mathew
    10 views11 pages
    The document discusses different types of cell signaling including cell surface receptors like ion-channel linked receptors which use rapid signals through multpass transmembrane channels, G-protein linked receptors which use indirect signals through 7-pass transmembrane proteins, and enzyme linked receptors which activate through ligand binding to single-pass transmembrane proteins. It also discusses signal transduction cascades, phosphorylation as a key mechanism, and two main types of GTP-binding proteins involved in intracellular signaling - trimeric G-proteins and monomeric GTPase proteins.

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    223.20 Principles of Cell Signaling2015

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    The document discusses different types of cell signaling including cell surface receptors like ion-channel linked receptors which use rapid signals through multpass transmembrane channels, G-protein linked receptors which use indirect signals through 7-pass transmembrane proteins, and enzyme linked receptors which activate through ligand binding to single-pass transmembrane proteins. It also discusses signal transduction cascades, phosphorylation as a key mechanism, and two main types of GTP-binding proteins involved in intracellular signaling - trimeric G-proteins and monomeric GTPase proteins.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    10 views11 pages

    223.20 Principles of Cell Signaling2015

    Uploaded by

    Abhishek Isaac Mathew
    The document discusses different types of cell signaling including cell surface receptors like ion-channel linked receptors which use rapid signals through multpass transmembrane channels, G-protein linked receptors which use indirect signals through 7-pass transmembrane proteins, and enzyme linked receptors which activate through ligand binding to single-pass transmembrane proteins. It also discusses signal transduction cascades, phosphorylation as a key mechanism, and two main types of GTP-binding proteins involved in intracellular signaling - trimeric G-proteins and monomeric GTPase proteins.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 11

    2015-11-22

    223.20
    Principles of Cell Signaling

    Cell Signaling-Receptors

    2015-11-22

    Cell Signaling-Receptors: Intracellular

    Cell Signaling

    2015-11-22

    Cell Signaling

    Cell Signaling-four general kinds

    2015-11-22

    Cell Signaling - Contact dependent

    Autocrine Signaling

    2015-11-22

    Cell Signaling - Cell Surface Receptors: Ion-channel linked


    Rapid signal
    Multipass transmembrane channel
    protein changes potential

    2015-11-22

    Cell Signaling - Cell Surface Receptors: G-protein linked


    Indirect signal
    7-pass transmembrane protein
    with conformational change

    Cell Signaling - Cell Surface Receptors: Enzyme linked


    Ligand binding activates
    receptors catalytic domains
    single-pass transmembrane proteins

    2015-11-22

    223.20
    Principles of Cell Signaling

    Signal Transduction Cascade

    2015-11-22

    Signal Transduction Cascade

    Cell Signaling-Phosphorylation

    2015-11-22

    Cell Signaling-Phosphorylation

    Two main types of


    GTP-binding proteins
    1. Large trimeric GTPbinding proteins (Gproteins) relay
    messages from Gprotein-coupled
    receptors (next
    lecture)
    2. Monomeric GTP
    binding proteins that
    are GTPases (shown
    here)

    2015-11-22

    Cell Signaling

    Cell Signaling

    10

    2015-11-22

    Cell Signaling

    11

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