O O

40

Investigating the diagnostics of aorta stiffness

with a elastic oscillator model

18

... 1
... 2

... 3
... 4

3-1

......... 5

3-2

. 7

4-1

..... 9

4-2

.... 10

. 11

.. 12
....... 28

... 34

. 36
. 38
. 39

TTE

Investigating the diagnostics of aorta stiffness with

a elastic oscillator model
Abstract
U

According to the elastic oscillation model of physics, we found

that the aorta stiffness could be obtained by measuring the delay time
of the aorta relative to the cardiac motion. The idea was confirmed by
an analysis of the echocardiograph images of several samples. A
home-made mechanical model was also employed to simulate the
effect of cardiovascular thickness. The experimental results fitted the
theory very well, verifying the feasibility of the elastic oscillation
model. This measurement could be carried out with the conventional
echocardiography instruments, making it convenient and common.
Furthermore, the delay time could be measured with TaransThoracic
Echo (TTE) instead of TransEsophadeal Echo (TEE). This non-invasion
can avoid patients discomfort and side effect during medical process.
The quantitative measurement also enables that the diagnostics can be
progressed in advance.

(CT)
(MRI) TEE

E-mail


3-1

(CT)
(MRI)TEE

3-1

3-1

 3-2 R
3-3 3-3

(TEE)(TTE)

TTE

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()

t1 t

I
Z

3-2

3-3

cosZt1cosZt
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tan1( 3-4)I0
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3-2
Jean Baptiste Joseph Fourier, 1768-1830
heat propagation & diffusion
series of harmonically related
sinusoids

P QRS T U ( 3-5)

3-5

 f=1~7
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10


(A)
TEE (Agilent 500 TEE)

Ulead VideoStudio 6 ()

PhotoImpact

Excel

(B)

9V

LED 1

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( 1cm 2.5cm)

UV ( 0.8cm 30cm)

( 8cm4cm )

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Qualatex
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11

WK Model

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1
2

12

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1. (A) 1 1
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4. 1~3
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13

4.1

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5.9

5.05

1.8

1.5

2.1

2.05

93.05

90.84

516.97

605.59

2.8

11.1

0.093

0.267

0.370

2.05
(mm)

5.65
(mm)

3.6
(rcm)

1.4
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62.04
(Fdyne) 1
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172.32
(kdyne/cm) 2

(A )

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14

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(
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6-2
15

=1362551
6-3

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1.55u105 cm/s[7]
P

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0.342

0.3731

0.414

0.453

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5.75

5.05

5.65

5.15

3.1

1.75

2.8

2.05

1.65

1.6

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2.45

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108.6

235.85

405.14

458.94

529.58

2.1

3.1

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0.103

0.233

0.267

0.303

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1.95
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70.9
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17

(dyne/cm)

600
500

400

300

R2 = 0.9471

200

100
0.3

0.35

0.4

(mm)

6-5

6-6

18

0.45


12

10
8
6
4
2
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0.3

0.32

0.34

0.36

0.38

0.4

0.42

0.44

0.46

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6-6

6-7 3-4
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( 6-8(a))(

6-8(b))(8%)
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19


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6-8

(a)

(b)

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Qualatex (
260Q UV UV
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UV

(
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20

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40
35

31

32
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30

A =4.1
S=0.83

25
20
15
10
5
0

37

40

35

28

30

25
20

UV6hrs
A =5.5
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20

15

15
10
5
0

40
35

30
25

20

20

19

31

30

UV12hrs
A =6.7
S=1.10

15
10
5
0
40
35
28

30
25
20
15
10

UV16hrs
A =7.6
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28
S

22

A
13
9

5
0
40
35

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20
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10

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27

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23

UV24hrs
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A =8.6
A =8.6
S=1.26
S=1.26

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11

11

10

11

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21

 6-11 UV

(a)
(b)
6-12 (a) UV (b)
22

 UV
6-10 UV
6-11

6-12(a)(b)

()

UV

(mm)

(mm)

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12

18

24

1.6

2.4

2.4

2.8

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0.42

0.35

0.27

0.185

0.2

1.6

2.5

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70.90

110.78

104.13

124.07

146.23

168.8

316.5

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5.5

6.7

7.6

8.6

0.137

0.183

0.223

0.253

0.287

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23

(dyne/cm)

800
700
600
500
400
300

R = 0.9698

200
100
0
0

12

18

24

UV)*

6-13

UV

9
24hrs

8
18hrs

12hrs

7
6

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6hrs

5
4

3
160

260

360

460

560

660

k(dyne/cm)
6-14

24

760

(%)

120

24hrs

100

18hrs

80

12hrs

60
y = 0.1799x - 22.161
2
R = 0.9473

6hrs

40
20
0

0hr
150

250

350

450

550

650

750

(dyne/cm)

6-15

(%)

120

24hrs

100

18hrs

80

12hrs

60
6hrs

40

y = 30.365x + 8.2038
2

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20
0hr
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0.00

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1.50

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2.50

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(%)

100

(a)

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20
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S21
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30
6hrs

20
10

S23

S4

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150

250

350

450

550

650

750

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6-17 (a) UV
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3.70

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30

40

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27


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23 TEE 10
TTE TEE 7 32
22 50 100

23

6-8 ()
6-9 10 TEETTE
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23 5671516
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6
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( 6) 30 /
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29

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0.30

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30

0.00

()

0.20

0.23

0.27

10
9
8
7
6
5
4
3
2
1
0

 6-20 10 TEE TTE ()

TE E TTE

TEE
TTE

0.27
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0.17
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31

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9
8
7
6
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4
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A 9.3
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9.3

6-21 (100 )

( 91923 )

A 5.3
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6-22 (100 )

6-21 6-22
4~6

32


TEE

(TTE)
10 TEE
TTE

( 6-20) (

6-23)
TTE

6-23 (100 )

A ---TEE8.5TTE8.6
S ---TEE0.89TTE0.86

23

( 1-7.1)

()()100

WK Model

33


(1)

(angiography)--- X X
(2)
WK

Model


WK Model

()

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()

TEE
TTE

MPEG MPEG
30 0.03
1
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34

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35

0.2
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1.0

TTE

TEE

WK Model

---
36

R-

0.2 0.5~1.0
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TEE

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(
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37

7-1

38


1. ( 90)

2. ( 94)?38770~73
3. 94 10 14
http://www.doh.gov.tw/statistic/data/ /93
.xls

4. ( 91)

5. ( 89)/

6. ( 91)
7. ( 93)

8. ( 90)/

9. ( 75)
10. ( 79)
11. ( 92)

12. ( 90)
92 8 23 http://grc.mech. yzu.edu.tw.

13. ( 91 5 15 )
92 10 27 http://www.libert- ytimes.com.tw/2002/new

/may/15/today-m1.htm

14. ( 91 )
92 11 5 http://wwwphys.cycu.edu.tw/ ~choucl/Gphysics
/gen_phys/sho-2.php

15. () PCKweb
92 9 10 http://pck.bio.ncue.edu.tw/ pckweb/database/data2/ck

/ch04/supply/y86.htm

16. Robert Appleyard, PhD ( ) A Historical Perspective of

39

HemodynamicsHemodynamics Home Page 94 10 22

http://hemodynamics.ucdavis.edu/appleyard's%20review/
history_Appleyard.htm

17. BIOLOGICAL FLUID DYNAMICS (2004)ANNUAL SURVEY 94

10

23

survey2004pdf/ea16.pdf

40

http://www.vki.ac.be/research/themes/


1-1
100
60
52

50

40

38

30
20
10
7

3
0
5

normal
A 6.5 S0.67
67

6.49 5

41

1-2
100
35
30

30

25

23

20

17
14

15
10
6
5

5
3

2
0

0
5

10

11

12

13

normal
A 9.3 S1.57

9.32 5

42

1-3
100
60
49

50

S
40

30

24

20

15
11

10
1
0
5

normal
A 6.7 S0.89

43

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70
35

32

30

25

20
16
15

14

10

5
0
7

10

young aorta
A 8.3 S0.91

44

1-5
55
30

27

25

A
20

20
15
10

5
0
4

young aorta
A 5.2 S0.69

45

1-6
70
50

46

45
40

35
30
25

20

20
15
10
5

0
4

young aorta
A 5.2 S0.54

46

1-7
32
18
16 S

16
14

12
10
8

6
4
2
0
4

normal young
A 5.00 S0.72

1-7.1
16

47

3.0

3.5

4.0

4.5

5.0

5.5

6.0

6.5

11

48

16

21

26

1-7.1

31

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70
40
35

S
34

30

32

25
20
15
10
5

0
6

normal young
A 6.6 S0.60
(6.57)

49

1-9
48
20
18

18
16
14
12

12
10
8
6
4

6
4

A
2

2
0
7

10

11

12

aging aorta
A 9.7 S1.41

50

1-10
70
40
36

35

30

26

25
20
15
10

5
0
5

normal young
A 6.3 S0.65

51

1-11
100
70

60

50

60

40
30
21

18

20
10
1
0
5

normal
A 7.0 S0.66

7.0!

52

1-12
100

normal
A 6.3 S0.59

53

1-13
100

CAD (Coronary Artery Disease )

A 8.8 S1.01

8.8 1.01

54

1-14
100

(TEETTE)
normal

TEE--- A 7.2 S0.60

TTE--- A 6.8 S0.72

55

1-15
100

normal young

TEE--- A 5.4 S0.59

TTE--- A 5.7 S0.60

56

1-16
100

normal young

TEE--- A 5.3 S0.55

TTE--- A 5.1 S0.49

57

1-17
100

NO CAD

TEE--- A 6.5 S0.69

TTE--- A 6.6 S0.70

58

1-18
100

normal

TEE--- A 6.4 S0.66

TTE--- A 6.6 S0.64
6.5
5~6 1

59

1-19
100

CAD

TEE--- A 8.5 S0.89

TTE--- A 8.6 S0.86

8.6!

60

1-20
100

CAD

TEE--- A 8.3 S0.73

TTE--- A 8.4 S0.91

8.4 0.91
!

61

1-21
100

atheromatous

TEE--- A 5.9 S0.60

TTE--- A 5.8 S0.59

5.8

62

1-22
100

CAD

TEE--- A 6.3 S0.73

TTE--- A 6.6 S0.77

63

1-23
100

CAD

TEE--- A 8.3 S0.87

TTE--- A 8.3 S0.85

64