1.

Download and install the Wineskin Winery. Click update when it opens
and let it update, and then click the plus sign below the "Installed Engines"
window. A new window will appear. Choose the newest version from the drop
down menu and click "Download and Install".

2. Go back to the first Winery window and click "Create New Blank Wrapper".
You will be asked to name the wrapper. Name it Civilization V because it will be
your new application for opening Civ5. It prompted me to download a couple
more files in the process of creating the wrapper, and then it was created in my
temp folder.
3. Now go to where you downloaded the Civ5 torrent. After mounting the .dmg,
right click the Civ5 app and choose "show package contents". In the window
that opens, navigate to "drive_c/Program Files". Inside "Program Files" there is
a folder named "Sid Meier's Civilization V". Drag that folder onto your hard
drive. The desktop is fine.
4. Now navigate back to where you installed the new Wineskin Wrapper. Right
click the wrapper and choose "Show Package Contents". Now double click the
"Wineskin" application inside the window that opens. The app will start, and you
should choose "Install Software". Now click "Move a Folder Inside", and when
prompted navigate to and select the "Sid Meier's Civilization V" folder you
removed from the original torrent .dmg. You may be asked to verify the .exe file
from a drop down list. It's the one that says "/Program Files/Sid Meier's
Civilization V/CivilizationV.exe".
5. Exit out of everything and navigate back inside the package contents of your
new wineskin wrapper. Once again double click the Wineskin app inside the
window that opens. This time click on the "Advanced" button. Near the top of
the window that opens, check the box that says "Use Start.exe". In the bottom
right corner you can choose an icon for your app. You can copy and paste the
one from the torrent dmg.
6. Close everything again and double click on your new wineskin wrapper (Not
the wineskin app inside the wrappers package contents). Civilization should
launch now.