Professional Documents
Culture Documents
2016;2(1): 13-15
Journal homepage: www.ijcbr.com
Original Article
AUTHOR DETAILS
ABSTRACT
Professor, Dept. of
Biochemistry, The Oxford
Medical college, Hospital and
Research Centre, Bengaluru,
Karnataka, India.
ARTICLE INFO
Received: 10th June 2015,
Accepted: 13th Aug 2015.
*Corresponding author email:
drckh14@gmail.com
KEYWORDS
Alkaline phosphatase, Breast cancer, Metastasis, Isoenzymes.
INTRODUCTION
Breast cancer is one of the diseases most feared by women
and perceived as fatal world wide. In India breast cancer
accounts for 27.0 percent of all malignant cases (an incidence
rate of 25.8 per lakh & mortality rate being 12.7/lakh
population)[1]. Breast tumor in women has shown an
increased prevalence worldwide, both in industrialized and
developing countries. Various theories propounded are based
on altered hormonal milieu, personal and demographic
factors and certain agents such as radiant energy, oncogenic
viruses and chemical carcinogens which induces neoplastic
transformation of the cell.[2]
Educating the women about the value of periodic self
examination of the breast will help in detection of breast
cancer in early stage. Cancer that is detected early can
potentially be cured when the tumor is small enough to be
completely removed surgically. Unfortunately, most cancers
do not produce any symptoms until the tumors are either
too large to be removed surgically or cancerous cells have
already spread to other tissues i.e., metastasis has taken
13
Chandrakanth KH et al.
STATISTICAL ANALYSIS
All the measurements were expressed as mean SD and
range values. Unpaired t test was used for finding the
significant difference between two groups. One-way ANOVA
was used for multiple group comparison. In carcinoma
patients, changes in the serum levels of biochemical
parameter after surgery was analyzed by paired-t test for each
stage. For all the tests p-value of <0.05 was considered as
statistically significant.
F - VALUE
497.88
576.74
t-VALUE:
12.34 *
II
III
I
V
MEAN SD
PRE-OP
11
135.3622.11
POST-OP
11
130.7627.85
PRE-OP
18
167.1613.59
POST-OP
18
129.977.45
PRE-OP
18
298.2118.44
POST-OP
18
211.569.54
PRE-OP
13
415.0830.35
POST-OP
13
265.5117.65
STAGE I
STAGE II
22%
30%
tVALUE
SIGNIFIC
ANCE
1.58
0.145, NS
10.97
<0.001,
HS
22.75
<0.001,
HS
14.96
<0.001,
HS
STAGE III
STAGE IV
18%
30%
RESULTS
Table 1. Comparison of mean serum Alkaline phosphatase
(ALP) levels in controls & breast cancer patients.
Figure 1. Showing number of cases in different stages
STAGES
MEANSD
RANGE
CONTROL
35
94.8525.13
41.2 140.3
DISCUSSION
11
135.3622.11
111.2 180.1
II
18
167.1613.59
148.1 188.8
III
18
298.2118.44
271.0 333.5
IV
13
415.0830.35
374.1 456.2
Chandrakanth KH et al.
14
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[14]
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CONCLUSION
Our study reveals higher ALP levels in breast cancer when
compared to controls. Progressive increase in serum ALP in
the study may be due to metastasis. Serial analysis using
plasma Alkaline phosphatase isoenzymes combined with
other parameters like Gamma glutamyl transferase (GGT) for
the detection of metastasis would seem to be justified. Such
measurements, though less sensitive than imaging
procedures, can assist in screening for, early detection of a
considerable proportion of metastasis and to monitor the
treatment in breast cancer. Study indicates measurement of
serum ALP is cost effective and may be useful in smaller
laboratories where sophisticated laboratory and reliable
cancer marker are not available.
REFERENCES
1)
Chandrakanth KH et al.
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