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Congress of the United States ‘Washington, DE 20515 Mareh 16, 2016 The Honorable Rodney Fretinghuysen The Honorable Pete Visclosky Chairman Ranking Member Subcommittee on Defense Subcommittee on Defense ‘Committee on Appropriations ‘Commitee on Appropriations US. House of Representatives US. House of Representatives Washington, DC 20515 Washington, DC 20815 Dear Chairman Frelinghuysen and Ranking Member Viselosky: ‘Thank you for your interest in and continued suppor of the Gulf War lness Research Program (GWIRP) within the Department of Defense (DoD) Congressionally Directed Medical Research Programs (CMRP). As your Subcommittee begins work on FY2017 DoD appropriations, we respectfully request adequate funding for the GWIRP. Since its inception, the GWIRP has demonstrated significant progress in developing treatments for Gulf War liness. The 2014 update report of the Congressionally-mandated Researeh Advisory Committee on Gulf War Veterans’ Illnesses (RAC), which built on landmark RAC 2008 and Institute of Medicine JOM) 2010 reports, concluded: © *Sciemfic esearch [since 2008)... supports and further substantiates ... that Gui War illness isa serious physical disease, affecting atleast 175,000 veterans of the 1990-1991 Gulf War, that resulted from hazardous exposures in the Gulf War thecter: . ‘Symptoms typically include some combination of widespread pain, headache, Persistent problems with memory and thinking, fatigue breathing problems, soriach and intestinal symptoms, and skin abnormalities.” © “Research has found an elevated incidence of ALS [Lou Giebtig’s Disease,” and Gulf War veterane who were most expoced tothe elenee af neeve gas hy the destruction ofthe Khamisiyah Iragi arms depot have significantly elevated rates of death due to brain cancer.” There are concems forthe heath ofthis vulnerable population as time progresses. ‘© “Treatment research has increased significantly since 2008, panicularly refleting the work of the Gull War ness Research Program [at] CDMRP. ..Eary results provide encouraging signs that the treatment goals identified in the 2010 Institute of Meeieine report are achievable: to speed the development of effective treatments, cures, and, itis hoped, preventions.”” ‘The 2014 RAC update report also noted the relevance ofthis research “to protect the health of current and future American servicemen and women a risk of similar exposures.” A 2016 10M. "update report “found Title evidence to warrant changes tothe conclusions made by the [2010 JOM] committee” The GWIRD has shown itself to be a model on how to conduct treatment-oriented research fo address a challenging illness, and is succeeding where earlier programs failed © By Congressional design, the GWIRP is narrowly focused on “improving the health and lives of veterans who have Gulf War Illness.” by Funding “innovative Gulf War lness research to identify effective treatments, improve definition and diagnosis, and better understand pathobiology and symptoms © GWIRP’s highly competitive, multi-stage peer-reviewed process is open to all researchers, whereas VA research is restricted to VA staff, few of whom have expertise inthis rapidly-evolving, cuting-edge area © GWIRP-funded research aimed at unlocking GWT's underlying mechanisms is shovving great promise, and has found that even low-dose chemical warfare agent andor pesticide exposite lead to persistent brain changes associated with GWI, evidence of'a GWI chronic central nervous system inflammatory state; a potential explanation of GWWI immunological dysfunction; inflammation and immune

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