Renin-angiotensin system

Dr Mohammad Waseem kausar

 involved in the regulation of blood pressure and
electrolyte metabolism (through production of
aldosterone).
 angiotensin II, an octapeptide made from
angiotensinogen a large α2-globulin made in liver, is the
substrate for renin, an enzyme produced in the
juxtaglomerular cells of the renal afferent arteriole.
The position of these cells makes them particularly
sensitive to blood pressure changes, and many of the
physiologic regulators of renin release act through renal
baroreceptors.
Formation and metabolism of angiotensins
Structure of the juxtaglomerular
apparatus
Angiotensin-converting enzyme, a glycoprotein found
in lung, endothelial cells, and plasma, removes two
carboxyl terminal amino acids from the decapeptide
angiotensin I to form angiotensin II in a step that is
not thought to be rate-limiting.
Various nonapeptide analogs of angiotensin I and
other compounds act as competitive inhibitors of
converting enzyme and are used to treat renin-
dependent hypertension. angiotensin-converting
enzyme (ACE) inhibitors.