5. Enumerate the conditions associated with an increased or decreased platelet count.

a. decreased platelet count:

Impaired or Decreased Production of Platelets
Congenital
May-Hegglin anomaly
Bernard-Soulier syndrome
Fechtner syndrome
Sebastian syndrome
Epstein syndrome
Montreal platelet syndrome
Fanconi anemia
Wiskott-Aldrich syndrome
Thrombocytopenia with absent radii (TAR) syndrome
Congenital amegakaryocytic thrombocytopenia
Autosomal dominant and X-linked thrombocytopenia
Neonatal
Acquired
Viral
Drug induced
Increased Platelet Destruction
Immune
Acute and chronic immune thrombocytopenic purpura
Drug induced: immunologic
Heparin induced thrombocytopenia
Neonatal alloimmune (isoimmune neonatal) thrombocytopenia
Neonatal autoimmune thrombocytopenia
Posttransfusion isoimmune thrombocytopenia
Secondary autoimmune thrombocytopenia
Nonimmune
Thrombocytopenia in pregnancy and preeclampsia
Human immunodeficiency virus infection
Hemolytic disease of the newborn
Thrombotic thrombocytopenia purpura
Disseminated intravascular coagulation
Hemolytic uremic syndrome
Drug induced
Abnormalities of Distribution or Dilution
Splenic sequestration
Kasabach-Merritt syndrome
Hypothermia
Loss of platelets: massive blood transfusions, extracorporeal circulation
Common Drugs Causing Immune Thrombocytopenia
Analgesics
Salicylates
Acetaminophen
Phenylbutazone
Antibiotics

Cephalothin
Penicillin
Streptomycin
Aminosalicylic acid
Rifampin
Novobiocin
Various sulfa drugs (chlorthalidone, furosemide)
Alkaloids
Quinidine
Quinine
Sedatives, anticonvulsants
Methoin
Troxidone
Chlorpromazine
Diphenylhydantoin
Meprobamate
Phenobarbital
Carbamazepine
Oral hypoglycemics
Chlorpropamide
Tolbutamide
Heavy metals
Gold
Mercury
Bismuth
Organic arsenicals
Miscellaneous
Chloroquine
Chlorothiazide
Insecticides
b. Increased Platelet Count:
Conditions Associated with Reactive Thrombocytosis
Blood loss and surgery
Splenectomy
Iron deficiency anemia
Inflammation and disease
Stress or exercise
Myeloproliferative Disorders Associated with
Thrombocytosis
Polycythemia vera
Chronic myelogenous leukemia
Myelofibrosis with myeloid metaplasia
Thrombocythemia: essential or primary
Source: HEMATOLOGY: CLINICAL PRINCIPLES AND APPLICATIONS by Saunders, an
imprint
of Elsevier Inc.