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  • Journal, 3 (1) .: Ignacio, Richelle Angelika E. 3bio2

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    Richelle Ignacio
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    This document summarizes a case report on primary cutaneous leiomyosarcoma (PCL), a rare soft tissue tumor. The case report describes 4 cases of PCL, presenting clinical and histological details. All 4 cases presented as nodular growths and were graded a histological Grade 2. Surgical excision with hematoxylin & eosin staining was used for diagnosis. Careful pathological examination is needed to differentiate PCL from benign lesions, as local recurrence and distant metastasis can occur years later.

    Original Description:

    Histopathology of Leiomyosarcoma

    Original Title

    Leiomyosarcoma

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    This document summarizes a case report on primary cutaneous leiomyosarcoma (PCL), a rare soft tissue tumor. The case report describes 4 cases of PCL, presenting clinical and histological details. All 4 cases presented as nodular growths and were graded a histological Grade 2. Surgical excision with hematoxylin & eosin staining was used for diagnosis. Careful pathological examination is needed to differentiate PCL from benign lesions, as local recurrence and distant metastasis can occur years later.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    10 views7 pages

    Journal, 3 (1) .: Ignacio, Richelle Angelika E. 3bio2

    Uploaded by

    Richelle Ignacio
    This document summarizes a case report on primary cutaneous leiomyosarcoma (PCL), a rare soft tissue tumor. The case report describes 4 cases of PCL, presenting clinical and histological details. All 4 cases presented as nodular growths and were graded a histological Grade 2. Surgical excision with hematoxylin & eosin staining was used for diagnosis. Careful pathological examination is needed to differentiate PCL from benign lesions, as local recurrence and distant metastasis can occur years later.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 7

    Limaiem, F., Chelly, I., Bellil, S.

    , Mekni,
    A., Nidhameddine, K., Haouet, S., et
    al. (2007). Primary Cutaneous
    Leiomyosarcoma: A histological and
    immunohistochemical study of 4
    cases. Egyptian Dermatology Online
    Journal , 3 (1).

    Ignacio, Richelle Angelika E.

    3Bio2

    Abstract

    What is Primary Cutaneous


    Leiomyosarcoma (PCL)?
    Leiomyosarcoma is an
    aggressive soft tissue
    sarcoma derived from
    smooth muscle cells
    typically of uterine,
    gastrointestinal or
    soft tissue origin.
    Primary cutaneous
    leiomyosarcoma (PCL)
    of the skin is a rare
    soft tissue tumor.

    Methodology

    Surgical
    excision

    Hematoxy
    lin &
    Eosin
    staining

    Note: Only the following information regarding the methodology is available due to the
    article being a case report

    Results
    CASE 1

    CASE 2

    CASE 3

    CASE 4

    Location

    Chin

    Scrotum

    Lower lip

    Shoulder

    Growth
    pattern

    Nodular

    Nodular

    Nodular

    Nodular

    Atypia

    Moderate

    Marked

    Mild

    Moderate

    Giant
    multinucleat
    e cells

    Necrosis

    + (<50%)

    + (<50%)

    Ulceration

    Extension to
    subcutaneo
    us fat

    Histological
    Grade

    Grade 2

    Grade 2

    Grade 2

    Grade 2

    Results

    Conclusion
    In the presence of a small biopsy,
    PCL may be misinterpreted as benign
    smooth muscle proliferation such as
    leiomyoma. Therefore, careful scrutiny
    of cytological details in multiple
    sections, clinicopathological correlation
    and
    immunohistochemistry
    are
    mandatory for definitive diagnosis.
    Local
    recurrence
    and
    distant
    metastasis can occur years after the

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