ProteinSynthesis

Author:MegLicht
Datecreated:05/27/20158:49PMCDTDatemodified:05/01/20168:42PMCDT

Date

04/22/16

Subject

Biology,Science

Topic

DNAreplication(Transcription/Translation),Proteinsynthesis

Grade/Level

Grade10,Grade11,Grade12

TheBigIdea(s)orEssential
Question(s)

Whatarethestepsofprotiensynthesisandwheredotheyhappeninthecell?
HowdoDNAandRNAinteracttomakegenesintoproteins?

MulticulturalGoals(checkone
ormore)

Combattingracism,prejudice,anddiscriminationAlllivingorganismsarebuiltfromthesame5nitrogenousbaseswhichcodefor
thesame20aminoacids.

StateofIdahoand/orcommon
corestandardsaddressed

USANextGenerationScienceStandards(2013)
Grade/Level:
HighSchoolLifeSciences
Area:
HSLS1FromMoleculestoOrganisms:StructuresandProcesses
Standard:
HSLS11.ConstructanexplanationbasedonevidenceforhowthestructureofDNAdeterminesthestructureof
proteinswhichcarryouttheessentialfunctionsoflifethroughsystemsofspecializedcells.
Standard:
HSLS12.Developanduseamodeltoillustratethehierarchicalorganizationofinteractingsystemsthatprovide
specificfunctionswithinmulticellularorganisms.
Area:
HSLS3Heredity:InheritanceandVariationofTraits
Standard:
HSLS31.AskquestionstoclarifyrelationshipsabouttheroleofDNAandchromosomesincodingtheinstructions
forcharacteristictraitspassedfromparentstooffspring.
Standard:
HSLS32.Makeanddefendaclaimbasedonevidencethatinheritablegeneticvariationsmayresultfrom:(1)new
geneticcombinationsthroughmeiosis,(2)viableerrorsoccurringduringreplication,and/or(3)mutationscausedby
environmentalfactors.
Area:
HSLS4BiologicalEvolution:UnityandDiversity
Standard:
HSLS41.Communicatescientificinformationthatcommonancestryandbiologicalevolutionaresupportedby
multiplelinesofempiricalevidence.

Objectives

SWBATtranslateanmRNAsequenceintoapolypeptidechainwith100%accuracy.
SWBATtranscribeaDNAstrandintoanmRNAstrandwith100%accuracy.
APBiologySWBATanswerquestionsontheAPbiologytestrelatedtoproteinsynthesis.

Materialsand/ortechnology

ELMO,hoolahoop,scratchpaperfortranscribingandtranslating,tshirtslabeledwiththe20aminoacids,tape,
scissors,markers,'lifesize"mRNAstrand

Activities/Procedures(IncludeAnticipatedTimeForEach)
Introduction/Activator

Warmup(writtenontheboardwhenthestudentscomein.ThisisadailyoccurencesotheyknowtoworkonitwhileI
takerollandhandbackgradedpapers)
HavethestudentstranscribeaDNAsequenceintoanmRNAsequence.
Ex:CATTTACACGCCTATGGCTGACATTCGTA

Classactivities(what
you/studentswilldo)

1)Checkthetranscribedsequenceforaccuracy.
Examplefromactivator:GUAAAUGUGCGGAUACCGACUGUAAGCAU
2)LayoutthelifesizedversionofthemRNAstrand(eachlettergetsan8.5"x11"pieceofprinterpaper.Theyare
tapedtogetheratthesidesandstoredina3ringbinder)
3)CreateapolypepetidechainasaclassbyhavingstudentsstandinfortRNA.(Thehoolahooprepresentsthe
ribosome,andapaperchainrepresentsthepolypeptide)

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4)Afteryouhavecreatedthepolypeptidechain,discussthedifferentbondsintheprocess,codonsvsanticodons,the
differenttypesofRNA,etc.
5)Competitions.Canuseavarietyofrewardsforthewinningteams.Eachroundhasawinner.Youcantranscribe
and/ortranslateintopaperpolypeptidechains.Attheendtheclassneedstomakeapolypeptidechainwiththeir
bodiesastheaminoacids(thisiswherethetshirtscomein)theylinkarmstoformpeptidebonds.
Attachments:
1. teams001.jpg
2. warmup001.jpg
3. wholeclass001.jpg

Classactivities(whyyouwill
dothem)

Sothatthestudentscanhaveavisual/kinestheticrepresentationoftranscriptionandtranslation.
SothatstudentscanpracticetranscribingandtranslatingstrandsofDNA/RNA.
SostudentscananswerquestionsaboutproteinsynthesisontheAPexam.

Closure/reminders

Forreview,looktopages128134intheCliffsNotesAPBiologyEdition4orBozemanScienceAPBiologyDNA&RNA
Part2.
Attachments:
1. 128001.jpg
2.
3.
4.
5.
6.
7.

129001.jpg
130001.jpg
131001.jpg
132001.jpg
133001.jpg
134001.jpg

Links:
1. DNARNApt2

Assessment

Checkeachgroup'schainforaccuracyeachround.Mustget100%oftheaminoacidscorrecttowin.Addressany
misconceptionsduringtheactivityandredopartsisnecessary.TheseskillswillbeassessedontheAPexamorona
unittest.

Accommodations/differentiation

Studentsareworkingingroupssothatthosethatunderstandcanassistthosewhoneedmoreassistance.Thisis
goodforalltypesoflearnersbecauseitiskinetic,auditory,visual,etc.Icoldcallatvarioustimesduringthelessonto
checkengagementandunderstanding.

Reflection/Evaluation

Ihavetaughtthislessonmultipletimeswithavarietyofclassesin3differentschools.ThestudentsandIbothloveitbecauseitisfun,
engaging,andreallyhelpstobringproteinsynthesistolife.Itgoesslowerinlowerlevelclassesandwehavelesstimetodocompetitive
groupsattheendbutitcanbemodifiedforanyhighschoollevelbiologyclass.Ihaveuseditbothasanintroductionandasareview,
thoughitworksbestasareview.Itcanalsobebrokenupintotwolessons,onebeingthedemonstrationandtheotherbeingthe
competition.

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