Peripheral Nerve Injury

Seddons Classification
Neuropraxia
Axonotmesis
Neurotmesis
Intact
Interruption
Interruption
Axon
Wallerian
Degeneration
Descripti
Local myelin injury Connective
Connective tissue
on
Myelin/CT
tissue/Schwann cell
disruption
intact
Conductio Conduction block
Conduction failure
Conduction failure
n
Nerve compression Nerve crush injury
Nerve transection
Etiology
injury
injury
Recovers within a Good prognosis
Aberrant
few days to
because the
regeneration and
weeks/months
endoneurium
neuroma
remains intact
formation
Rate of nerve
Surgical
regrowth is 1-2
modification of
Prognosis
mm/day
nerve ends
required
Prognosis guarded
and dependent on
nature of injury
and local factors

Type
1
2
3
4
5

Sunderlands Classification
Description
Conduction block (neuropraxia)
Axonal injury (axonotmesis)
Type 2 + endoneurium injury
Type 3 + perineurium injury
Type 4 + epineurium injury (neurotmesis)/Severance
of entire nerve