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ReversingType2DiabetesNewcastleMagneticResonanceCentreNewcastleUniversity

NewcastleUniversity

NewcastleMagneticResonanceCentre

ReversingType2Diabetes
Ourworkhasshownthattype2diabetesisnotinevitablyprogressiveandlifelong.Wehavedemonstratedthatin
manypeoplewhohavehadtype2diabetesforupto10years,majorweightlossreturnsinsulinsecretiontonormal.
Ithasbeenpossibletoworkoutthebasicmechanismswhichleadtotype2diabetes.Toomuchfatwithinliverand
pancreaspreventsnormalinsulinactionandpreventsnormalinsulinsecretion.Bothdefectsarereversibleby
substantialweightloss.
Acrucialpointisthatindividualshavedifferentlevelsoftoleranceoffatwithinliverandpancreas.Onlywhena
personhasmorefatthantheycancopewithdoestype2diabetesdevelop.Inotherwords,onceapersoncrosses
theirpersonalfatthreshold,type2diabetesdevelops.Oncetheysuccessfullyloseweightandgobelowtheir
personalfatthreshold,diabeteswilldisappear.
SomepeoplecantolerateaBMIof40ormorewithoutgettingdiabetes.OtherscannottolerateaBMIof22without
diabetesappearing,astheirbodiesaresettofunctionnormallyataBMIof,say19.Thisisespeciallysoinpeopleof
SouthAsianethnicity.
Informationforpeoplewithdiabetes
Downloadtheinformationleaflet:ReversingType2Diabetes(documents/DiabetesReversaloftype2studyJune15.pdf)
(PDF:269KB).
ProfessorTaylor'sNewcastleUniversityPublicLectureonreversingtype2diabetes(4thNovember2014)can
beviewedhere(https://campus.recap.ncl.ac.uk/Panopto/Pages/Viewer.aspx?id=c3bef819e5f44a55876f0a23436988ed).
ReadRichardDoughty'spersonalstoryType2diabetesandthedietthatcuredme
(http://www.guardian.co.uk/lifeandstyle/2013/may/12/type2diabetesdietcure)ontheGuardianwebsite,includingavideo
interviewofanotherpersonalstoryandanupdatefromRichard,Ireversedmydiabetesinjust11days
(http://www.dailymail.co.uk/health/article2385179/Ireverseddiabetesjust11daysgoingstarvationdiet.html),ontheMail
Online.
GetsamplevegetablerecipesandmealplansfromtheReversingDiabetesLowCalorieDietProgramme
(documents/StudyRecipes.pdf)(PDF:375KB)devisedbyMissKarenHeron,Dietician,NewcastleDiabetes
Centre.MoreinformationonlowcaloriedietsisavailablefromtheDiabetesUKwebsite
(http://www.diabetes.org.uk).
TheBritishHeartFoundation(http://www.bhf.org.uk/)provideadviceonweightloss.
FurtherInformation
Readourlatestpaper,asmentionedinthecurrentnewsitem:Verylowcaloriedietand6monthsofweight
stabilityintype2diabetes:Pathophysiologicchangesinrespondersandnonresponders
(documents/VerylowcaloriedietS.Stevenetal.pdf).
Seealsoourpaperondietversussurgery(documents/PancreaspaperdietvssurgeryS.Stevenetal.pdf).
Readourarticle:RestoringnormoglycaemiabyuseofaverylowcaloriedietinlongandshortdurationType
2diabetes(documents/Restoringnormoglycaemia.pdf),regardingtheeffectofthedurationoftype2diabeteson
reversibility.
Data(http://www.clinsci.org/content/128/7/405)fromtheUnitedKingdomProspectiveDiabetesStudy(UKPDS)
helpstoexplainwhynonobesepeopledeveloptype2diabetes.
ResearchinspiredaChannel4special(http://www.channel4.com/programmes/thefoodhospital)resultinginwomen
reversingtheirType2diabetes.Toreadmoreabouttheoriginaltrialseethepressrelease
(../../../press/news/2015/10/type2diabetes/).
TheHairyBikersturnedHairyDietersandmetwithProfessorRoyTaylorandnutritionistProfessorAshley
AdamsonforadvicetheresultswereseeninthefourpartseriesHairyDieters:Howtolovefoodandlose
weight(http://www.bbc.co.uk/programmes/p00vq8c6)(BBC2August2012,repeatedJanuary2013).Further
informationontheprogrammeincludingexperts'hintsandtips
(http://www.bbc.co.uk/programmes/articles/lp65rvLtfcSRxgfVgKtSqn/hintsandtips)andregularupdatesontheHairy
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Dieters'progresscanbeseenontheBBCwebsite.TheprogrammepromotedtheUniversity'saimtohelpus
alllivehealthy,longerlives(../../../ageing/)andtoencourageusallonthatpath.
AwardofMajorGrant
InOctober2013,DiabetesUK(https://www.diabetes.org.uk/Research/Ourresearchprojects/Scotland/TheDiRECTroutetoType
2remission/)announcedtheawardofitslargestresearchgrantever.Itbuildsuponthebreakthroughinunderstanding
thepathophysiologyofdiabetesandtherelateddemonstrationthatshorttermtype2diabetescouldbereversedto
normal.ThisisbroughttogetherwithworkconductedinGlasgowonuseoflowcalorieliquiddietsinprimarycare.
Thestudywillanswertwomainquestions:
Cantype2diabetesberoutinelyreversedinPrimaryCare?
Isthelongtermeffectofthisinterventionbetterthanconventionaltreatment?
ThestudywillbeknownasDiRECT(http://www.directclinicaltrial.org.uk/)(DIabetesREmissionClinicalTrial).Participating
generalpracticesinNewcastleandGlasgowwillberandomisedeithertousethelowcaloriedietfollowedbyan
intensiveweightmaintenance2yearphase,ortobestpossiblecareaccordingtocurrentguidelines.Inorderto
deliverthelowcaloriediet,togetherwiththecriticallyimportantbackupandsupport,primarycarestaffwillbetrained
bythestudyteam.TheexpertiseofProfessorAshleyAdamson,ProfessorofHumanNutritioninNewcastleandDr
FalkoSniehotta,ReaderinHealthPsychology,willbecombinedwithpreviousexperiencedspecialistdieticiansfrom
CounterweightLtd.Counterweightwasformedasacompanyinordertokeeptogethertheexpertisedeveloped
duringtheCounterweightProjectwhichhasbeenhighlysuccessfulinachievingandmaintainingweightlossinthe
primarycaresetting.
StudyvolunteersintheNewcastleareawillalsoundergodetailedmagneticresonanceinvestigationscoupledwith
metabolicteststoexaminefurtherthebasicmechanismswhichbringaboutthereturntonormalbloodglucose
control.Additionally,detailedpsychologicalassessmentswillbecarriedouttounderstandtheresponseofindividuals
tothismanagementapproachandidentifyfactorswhicheffectadherence.
Thephaseofappointingandtrainingstaffisnowunderway,andthefirstvolunteerswillbejoiningthestudyinApril
2014.Allrecruitmentwillbeviaparticipatinggeneralpractices.
Theprotocol(DiRECTprotocol.pdf.pdf)fortheDiRECTstudyhasrecentlybeenpublished.
ThisstudyisacollaborationbetweenProfessorMikeLean(http://www.gla.ac.uk/schools/medicine/staff/mikelean/),Professor
ofHumanNutritionatGlasgowUniversityandalsoProfessorRoyTaylor(../../staff/profile/roy.taylor),Professorof
MedicineandMetabolismatNewcastleUniversity,astheChiefInvestigators.ThePrincipalInvestigatorsare
ProfessorAshleyAdamson(../../../ihs/people/profile/ashley.adamson),ProfessorFalkoSniehotta
(../../../ihs/people/profile/falko.sniehotta),DrKierenHollingsworth(../../../icm/people/profile/kieren.hollingsworth)andProfessor
JohnMathers(../../../cisban/people/profile/john.mathers),ProfessorIanFord
(http://www.gla.ac.uk/researchinstitutes/healthwellbeing/staff/ianford/)andProfessorNaveedSattar
(http://www.gla.ac.uk/researchinstitutes/icams/staff/naveedsattar/).
Informationforyourdoctor
Itisimportantthatpeoplewithdiabetesdiscusstheirmanagementwiththeirowndoctor.Itwilltakeyearsforthis
newknowledgetobecomeincorporatedintotextbooksandguidelines,soyourdoctormaybewaryofinformation
fromtheinternet.
NewcastleUniversityresearchershavewrittensomenotesforyoutotaketoyourdoctor.Downloadourinformation
sheetfordoctorsonthepracticalmanagementoftype2diabetesinrespectofreversal
(documents/Informationfordoctors_revised_April14.pdf)(PDF:220KB).
Lectureslidesfordoctorsandscientists
Downloadourslideson:
Counterpoint(documents/TheTwinCycleHypothesis&Counterpoint.pdf)
Counterbalance(documents/Counterbalance.pdf)
Pancreasfat(documents/Pancreasfatintype2diabetesstudy.pdf)
DiRECT(documents/DiRECTprotocol.pdf)
PersonalFatThreshold(PersonalFatThresholdconcept.pdf.pdf)
FurtherReading
In2008,wepublishedtheTwinCycleHypothesistoexplainthecauseoftype2diabetes.Thishypothesis
predictedthatdietcouldentirelyreversetype2diabetes.Readourscientificreview,Pathogenesisoftype2
diabetes(http://www.ncbi.nlm.nih.gov/pubmed/18726585?
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ordinalpos=183&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

ontheUSNationalLibraryofMedicinewebsite.
AclinicalstudydesignedtotestthehypothesiswasfundedbyDiabetesUK.Theresultswereveryclear.
Weightlossaveraging15kg(2stone5lb)achievedover8weekscausedtwodistinctsetsofchanges.Within7
days,liverfathadfallenby30%,liverinsulinsensitivityhadreturnedtonormalandfastingbloodglucosehad
becomenormal.By8weeks,pancreasfatcontenthadreturnedtonormalandinsulinsecretionbythe
pancreashadreturnedtonormal.Readthefullscientificpaper,Reversaloftype2diabetes
(http://www.ncbi.nlm.nih.gov/pubmed/21656330)andtherelatedNewcastleUniversityPressRelease,DietReverses
Type2Diabetes(../../../press.office/press.release/item/tvspecialshowsdietreversestype2diabetes).
Thisnewunderstandingofwhatcausestype2diabetesandhowitcanbecompletelyreversedhasbeenused
byindividualsworldwide,areporthasbeenpublisheddocumentingpracticalmanagementoftype2diabetes
inrespectofreversal(documents/CounterpointReflections.pdf)(PDF:84KB).
ProfessorTaylorwasawardedthe2012BantingLectureshipofDiabetesUK.ReadhislectureReversingthe
twincyclesofType2diabetes(documents/BantingDiabeticMed.pdf)(PDF:543KB).
ScientistsanddoctorswithaccesstothejournalDiabetesCare,canreadafullreviewofthescience
underlyingthismatter:Type2diabetes:etiologyandreversibility(http://www.ncbi.nlm.nih.gov/pubmed/23520370).

(http://www.ncbi.nlm.nih.gov/pubmed/18726585?
ordinalpos=183&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

NewcastleMagneticResonanceCentre
NewcastleUniversity,CampusforAgeing&Vitality
NewcastleuponTyne,NE45PL
UnitedKingdom.
EmailWebmaster (mailto:sandra.blackwood@ncl.ac.uk)
Lastupdated24March,2016 2016NewcastleUniversity(http://www.ncl.ac.uk/info/legal/copyright.html)

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