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Choroid
Inner surface smooth, brown and lies in
contact with pigment epithelium of retina.
Outer surface: rough and lies in contact with
the sclera.
Avg. about .25mm in thickness
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Choroid
Consist of 3 layers.
- Choriocapillaries the inner most layer.
- Stroma.
- Supra choroidal lamina outer layer
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Stroma
Consist of loose collagenous tissue, pigment
cells, macrophages, mast cells, plasma cells
and lymphocytes.
Main bulk is by vessels in 2 layers
- Outer layer of larger vessels: Hallers layer.
- inner layer of medium vessels: Sattlers layer
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Choriocapillaris
Sattlers layer connect with the
choriocapillaries.
Lying in the single plane beneath RPE.
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Choriocapillaries
Vessels walls thin with fenestration esp. the
surface facing the retina.
Fenestrated capillaries contain endothelial
cells joint by Zonular occludents.
Endothelial cells lined by basement
membrane containing pericytes.
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Bruch's Membrane
Innermost layer of the choroid.
Lies between Choriocapillaries and RPE.
Defects occur spontaneously in myopes ,in
trauma.
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Venous Drainage
Ant ciliary veins.
Smaller veins from sclera.
Vortex veins or post ciliary veins
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Anterior Chamber
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Anterior Chamber
Bounded antly by cornea and postly by ant
surface of iris and part of ciliary body
About 3m deep in adults.
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Anterior Chamber
Shallow in hyperopes.
Deep in myopes and aphakics.
Contains about 0.25ml of AH
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Angle structures
Ciliary body band
Scleral spur
Trabaecular meshwork
Schlemns canal.
Schwalbes line
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Narrow in hyperopes
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Scleral spur
Post portion of scleral sulcus
Usually white line on goniocopy
Attached at Ciliary body postly and corneo
Scleral meshwork
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Trabaecular meshwork
Function is for drainage of AH.
Roughly triangular in shape.
Apex: Schwalbes line.
Base: scleral spur
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Trabaecular meshwork
Divided into 3 parts:
- Uveal portion.
- Corneo scleral meshwork.
- Juxta canalicular tissue.
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Trabaecular meshwork
Uveal portion and corneo scleral meshwork
divided by Schwalbes line to scleral spur..
Uveal portion Lies internal to this line.
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Trabaecular meshwork
Pigmentation is variable.
Greater in brown iris than blue iris.
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Juxtacanalicular meshwork
Outer most portion of the TM.
Loosely arranged connective tissue lined on
either side by endothelium.
Juxtacanalicular meshwork
Gives normal resistance to aqueous outflow.
Lined on either side by endothelium
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Schlemms canal
Lined by endothelium.
Contains numerous opening of collector
channels.
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Collector channel
Called intrascleral aqueous vessels.
Leave SC obliquely to terminate ultimately
into episcleral veins.
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Schwalbes line
Fine ridge in front of TM.
End of Descemets membrane.
Forms ant structure of angle.
Lies in post corneal surface.
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Embryology.
Introduction
Three primary layers:
- Outer collagenous layer. (Sclera, cornea)
- Middle Vascular layer. (Uvea)
- Inner Sensory layer. ( retina , optic nerve)
Introduction
Embryology is important to know:
- Structure and its anatomic characteristics.
- Diseases of the eye.
- Pathogenesis of various congenital anomalies
Consist of:
Ectoderm.
Mesoderm.
Endoderm.
Orbit
4th week : Optic axes of two orbits are 1800
2nd month: 720
3rd month: 450
Lens
Derived for surface ectoderm.
3rd week of gestation.
Formation triggered by forward growth of
optic vesicle with surface ectoderm.
Lens
Lens capsule is thicker anteriorly than
posteriorly.
Formed by 5th week of gestation.
Lens
Development of primary lens nucleus.
Fibers extend form ant to post pole.
Each time new fibers formation.
Finally formation of Y sutures.
Lens
Linear junction where fibers terminate at ant
and post surface of lens forms Lens Sutures.
All fibers meet at single point leads to pit
formation leading to bad optical quality
Lens
Later in gestation and following birth
formation of these y sutures are irregular.
Retina
Sensory retina and RPE develop from two
layers of original Optic cup.
Ant rim of Optic cup: Epithelial layers of iris
and ciliary body.
Retina
Distal part of Optic vesicle forming Sensory
retina divides into 2 Zones:
- Outer Zones: 8 -9 rows of Nuclei.
- Inner zone: Devoid of nuclei called marginal
zone.
Retina
Five and half months of gestation all layers of
retina are developed.
Macula: 3rd month to 8th month of gestation.
Uvea
Stroma of 3 layers of Uvea are Mesodermally
derived.
Melanocytes: fifth month of gestation.
Iris: developd from 2 grem layers
- Ant stroma: Mesoderm
- Post pigment epithelium and sphincter:
neuroectoderm.
Sclera
Originates around seventh week of gestation.
Starts a limbus progress until it reaches
posterior pole at fifth month.
Crystalline lens
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Introduction
Biconvex.
Located in posterior chamber.
Behind pupil.
Held in position by zonules.
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Introduction
Transparent crystalline structure.
Power of about 20 D.
Avascular.
Posteriorly in contact with vitreous in circular area
called Weigers ligament.
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Introduction
Between the hyaloid face and lens capsule
small cavity called retrolental space or
Berger's space.
Its nourishment primarily by hyaloid artery
during fetal life.
Later by aqueous and vitreous.
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Introduction
Continuous to grow throughout life.
Color changes with age.
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Dimensons
At Birth:
EQ :
6.4mm
AP: 3.5
mm
WT: 90gm
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Dimensons
At Adult life.
EQ: 9-10mm.
AP: 5mm
WT: 255gm
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Other parameters
RI: 1.39
Anterior surface: 10mm
Posterior surface: 6mm.
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Structure
Three layers.
- lens capsule.
- Epithelium.
- Nucleus and cortex.
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Capsule
Thin transparent membrane.
Surrounds the lens.
Highly elastic.
Composed of type IV collagen fibers.
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Capsule
Anterior twice thicker than posterior.
Increases in thickness throughout.
Function : accommodation.
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Epithelium
Single layer of cuboidal nucleated epithelial
cells.
Beneath anterior and equatorial capsule.
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Epithelium
No attachment sites between lens epithelium
and basal lamina.
Cells undergo mitosis in pre equatorial zone.
Cell become elongated and descends to the
deeper layers.
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Epithelium
Absence of division at post capsule, leaves
post capsule clear.
Biosynthesis of DNA, RNA and Proteins takes
place.
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zonules
Supports lens.
Originate from basal lamina of non-pigmented
layer of ciliary body.
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Zonules
Made up of multiple filaments of collagen .
Insert lens capsule
- 1.5 mm ant capsule.
- 1.25 mm post capsule.
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Zonules
Diameter of each Zonule: 0.35-1 microns.
Function in accommodation.
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Vitreous
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General Features
Inert, transparent, colorless, jelly like,
hydrophilic gel acts as supporting str to the
eyeball.
Occupies 4/5th of the volume of the globe.
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Location
Bounded Antly by lens and ciliary body and
Postly by retina.
Adherence: 2mm ant and 4mm post to ora
serrata
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Attachments
Disc margin (outer rim area of Martigiane).
Perifoveal region.
Posterior lens capsule (hyaloidocapsular
ligament of Weiger)
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Composition
Largest, simplest, single piece connective
tissue.
- H2O content: 99%
- Weight: 40 gms.
- Volume: 4ml
- Viscosity : twice of water
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Structure
Divided into three parts
- hyaloid layer
- Cortical vitreous
- Medullary Vitreous
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Hyaloid Vitreous
Not a true membrane.
Str of connective tissue.
Fibrils run parallel to the surface
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Cortical vitreous
Refers to entire peripheral vitreous.
Approx.100 microns in width.
Condensed fibrillar vitreous.
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Cortical vitreous
Consist of type II collagen fibrils.
Interspersed with sodium mucopolysaccharide
molecules.
Represents 2% of total vitreous.
Product of neuro-ectoderm.
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Cortical vitreous
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Medullary vitreous
Forms vitreous body.
Similar to cortical vitreous.except for fibrils.
Centre to it is cloquets canal. Absent in
adults.
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Medullary vitreous
Represents remnants of hyaloid artery.
Mittendorf's dot represents remnants of the
ant end of hyaloid artery may be seen in
adults.
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Embryology: 3 stages
Ist stage: 1st month of gestation: Space- lens
and retina filled with primary vitreous.
IInd Stage: 2nd month of gestation: collagen
like fibrils and hyaluronic acid forms secondary
vitreous. represents adult vitreous.
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Embryology: 3 stages
14th week: secondary vitreous begins to fill the
vitreous cavity, by 7th month entire cavity.
Remnants of primary vitreous:SShaped called
Cloquets canal.
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Embryology: 3 stages
IIIrd Stage: tertiary or zonular fibrils develop.
Remants of foetal vasculature seen in adults
called as Mittendorf's dot.
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Function
Occupying major volume of the globe.
To absorb and redistribute forces applied to
surrounding ocular tissue.
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RETINA
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Introduction
Innermost ,delicate layer of the eye.
Post pole thickness: 0.56mm
At EQ: 0.18to 0.2mm.
At Ora Serrata:approx. 0.1mm
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Introduction
Highly developed tissue.
Appears purplish red.
After death: white opaque.
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Gross Anatomy
Extends from optic disc to ora serrata.
OPTIC DISC:
pale disc. About 1.5 mm dia.
All retinal layers terminate at optic disc.
Except NFL (lamina Cribrosa).
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Gross Anatomy
Macula:
- yellow spot.
- 5.5 mm dia.
- Temporal to optic disc.
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Gross Anatomy
Fovea: sensitive part
- depressed part of macula.
- 1.85 mm dia.
- Corresponds 50 of visual
field.
- Surrounding to it is
parafoveal and perifoveal
areas.
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Gross Anatomy
Foveola:
- central floor of fovea.
- 2 disc dia (3mm) away to temporal edge of
optic disc .
- 0.35 mm dia
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Gross Anatomy
Umbo:
- tiny depression in centre of foveola.
- Corresponds as foveolar reflex during
ophthalmoscopy
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Gross Anatomy
FAZ:
- located inside fovea but outside foveola
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Microscopic structures
RPE.
INL
IPL
ELM.
Ganglion layer
ONL
NFL
OPL
ILM
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Consist of
bipolar cells (INL)
Horizontal cells( OPL)
Amacrine cells (within OPL)
Mullers cell (within INL)
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Blood supply
Outer four layers:from RPE to ONL by
choriocapillaries.
Six inner layers: from OPL to ILM by central
retinal artery.
OPL supplied partly by CRA and
choriocapillaries
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Blood supply
Fovea an avascular zone supplied by
choriocapillaries.
Macula by CRA and cilioretinal artery
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EOM
For eye movements
4: rectii ( SR, MR, IR, LR)
2 oblique: (SO, IO)
1 levator palpebral superiors.
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Annulus of Zinn
Is a fibrous ring.
Common origin of rectus muscles.
Orbital apex surrounded by annulus of Zinn called
occulomotor foramen.
Serves opening for CN III, IV, V, VI.
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Spiral of Tiallux
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Oblique Muscle
Superior Oblique:
Origination: orbital Apex
above Annulus of Zinn.
Course: Medially upwards
towards Trochlea.
Thereafter runs postly
below SR form an angle of
510
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Superior Oblique
Action:
Primary Action: Intorsion
when globe abducted 390
Optical axis and Pulley of
SO make 900 Angle.
Secondary and tertiary
Action: Depression when
Adducted 510 Muscle axis
and Optical axis Coincide
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Inferior Oblique
Origination: from
Maxillary Bone posterior to
Orbital rim and lateral to
the orifice to Lacrimal
Fossa.
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Inferior Oblique
Action:
Primary action: extorsion
when globe abducted
390
Secondary and tertiary
action: elevation when
globe adducted 510
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Blood supply
Medial Rectus: Inferior muscular branch of
ophthalmic artery.
Inferior Rectus: Inferior muscular branch of
ophthalmic artery and infraorbital artery.
Lateral Rectus: Lacrimal artery.
Definitions
Muscle Cone: lies post to equator of EOM,
EOM sheath, Intermuscular membrane extends
postly to annulus of Zinn.
Muscle Capsule: extend form its origin to its
insertion. Near equator they thicken.
Definitions
Check ligaments: limit excursion of EOM. Act
as support structure to globe. Neither check
movements nor they are ligaments.
Inter muscular membrane: connects all rectii
with thin layer of tissue that underlies
conjunctiva