Professional Documents
Culture Documents
Abstract
Topical corticosteroids (TC) have greatly contributed to the dermatologists ability to effectively treat several difficult dermatoses. The
available range of formulations and potency gives flexibility to treat all groups of patients, different phases of disease, and different
anatomic sites. However, the rapid rise in incidence of improper use of these drugs by dermatologists, general physicians, and patients
threatens to bring disrepute to the entire group of these amazing drugs. Responsibility to disseminate proper knowledge regarding when,
where, and how to use TC both to internists and patients rests primarily with the dermatologist. Benefits of rational and ethical use
and the harm of overuse and misuse for nonmedical, specially for cosmetic purposes, should be clearly conveyed before penning a
prescription involving TC. Simultaneous efforts to use political, legal, and other institutions to prevent misuse of these drugs by rationing
their availability only through proper prescriptions will greatly help the cause. This will hopefully bring down both the extremes of ever
increasing cases of steroid-induced dermatoses on one hand and the irrational fears of using TC in well justified indications on the other.
Key Words: Abuse, adverse effects, ethical use, indications, misuse, rational use, steroid responsive dermatoses, topical corticosteroids
Introduction
The topical corticosteroids (TC) are among the most
commonly prescribed medication in an out-patient
dermatology setting since they were first introduced in early
1950s.[1-3] Probably no other group of drugs has had such
a profound impact on the speciality as TC. Using them,
it has become so much easier to treat several dermatoses
which otherwise were the cause of significant morbidity
among people.
DOI: 10.4103/0019-5154.97655
Address for correspondence: Dr. Sanjay Rathi, 143, Hill Cart Road,
Siliguri 734 001, West Bengal, India. E-mail: drsrathi2@gmail.com
251
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
Vehicle
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
Vehicle
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
American classification
I
British classification
I
Superpotent corticosteroids
Very potent
II
II
Potent corticosteroids
Potent
III
Upper mid-strength
corticosteroids
Lower mid-strength
corticosteroids
Indications
Alopecia areata
Nummular eczema
Psoriasis
IV
Mid-strength corticosteroids
V
Asteatotic eczema
Atopic dermatitis
III
Moderate
Nummular eczema
Seborrheic dermatitis
Severe dermatitis
Severe intertrigo (short-term)
Stasis dermatitis
Alclometasone dipropionate 0.05% cream or Dermatitis (diaper)
ointment
Dermatitis (eyelids)
Desonide 0.05% cream
Dermatitis (face)
VI
Mild corticosteroids
IV
Mild
Intertrigo
Perianal inflammation
2.5% ointment
Lotion and gels are the least greasy and occlusive of all
topical steroid vehicles. Lotions are useful for hairy areas
because they penetrate easily and leave little residue. Gel
dry quickly and can be applied on the scalp or other hairy
areas as they do not cause matting.[26,27] Foams and mousses
and shampoo are effective vehicle for delivering steroid to
the scalp but are costly.
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
Adverse effects of TC
TC are used primarily for their anti-inflammatory properties.
Paradoxically, the same mechanisms which mediate their
anti-inflammatory properties and underlie their usefulness
are also responsible for their adverse effects.[37] Besides
the cutaneous and systemic adverse effects [Table 5],
the phenomenon of steroid addiction, tachyphylaxis, and
contact dermatitis (CD) due to TC also needs to be borne
in mind.
Local effects
They are encountered more frequently and have become
more prevalent with the introduction of high potency TC.[30]
These side effects depend on potency of steroid, duration
of use (i.e. extended period), volume of the product applied
(i.e. excessive amount), site of application, age of the
patient and occlusion (if present).
254
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
Cutaneous
Milia
Telangiectasia
Purpura
Erythema
Perioral dermatitis
Rosacea
Acne
Rebound erythema
Steroid addiction
Cushings disease
Femoral head osteonecrosis
Cataracts
Glaucoma
Hypertrichosis
Photosensitisation
Hyperglycemia
Hypopigmentation
Hypertension
Hyperpigmentation
Hypocalcemia
Contact dermatitis
Peripheral edema
Tachyphylaxis
Topical steroid
dependent face
Courtesy *Adapted from Hengge et al.[38]
These include, atrophy, striae, telengiectasis, purpura, hypopigmentation, acneiform eruptions, rosacea-like perioral and
periorbital dermatitis, and hypertrichosis.[38-53] The normal
presentation of superficial infections can be altered when
TC are inappropriately used to treat bacterial or fungal
infections. A typical example of this is seen when someone
applies a TC to an itchy groin rash. If this is a fungal
infection, the rash gets redder, itchier, and spread more
extensively than a typical fungal infection. The resulting
rash is a bizarre pattern of widespread inflammation with
pustules called tinea incognito [Figure 1].
Tachyphylaxis
It is the tolerance that skin develops to the vasoconstrictive
action of TC. After repeated use of topical steroids, the
capillaries in the skin do not constrict well, requiring
higher dose or more frequent application of the steroid.
The ability of the blood vessels to constrict returns four
days after stopping therapy.[60,61]
It is now suggested that either poor patient compliance
or the natural course of disease activity (unrelated to the
therapy) may be the main reason behind tachyphylaxis.
For this reason, instituting, weekend therapy or pulse
therapy may at least resolve the compliance issue. If a TC
loses its effectiveness, it should be discontinued for 47
days and then restarted.[16]
Systemic effects
Topically applied high and ultra high potency TC can
be absorbed well enough to cause systemic side-effects.
Hypothalamic-pituitary-adrenal suppression, glaucoma,
hyperglycemia, hypertension, and other systemic sideeffects have been reported, though rare.[54-58]
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
Conclusions
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
References
257
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
Rathi and DSouza: Rational and ethical use of TC based on safety and efficacy
68. Rapaport MJ, Rapaport VH. Serum nitric oxide level in red
patients: Separating cortico-steroid-addicted patients from those
with chronic eczema. Arch Dermatol 2004;140:1013-4.
69. Saraswat A. Topical corticosteroid use in children: Adverse
effects and how to minimize them. Indian J Dermatol Venereol
Leprol 2010;76:225-8.
70. Feldmann RJ, Maibach HI. Regional variation in percutaneous
penetration of 14C cortisol in man. J Invest Dermatol
1967;48:181-3.
Announcement
CUTICON WB 2012
16TH STATE CONFERENCE OF IADVL, WB STATE BRANCH
A State Conference with an International Touch
22nd and 23rd December, 2012
Swabhumi, Eastern Metropolitan Bypass, Kolkata
Highlights:
1.
2.
3.
4.