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1Chairman, Prof. and 2Course-coordinator of International Co-operation. Co- Supervisors: Prof. F. H. Sirazee 3(Ex. Head of the Department ), Associate Prof. P.C Debenath 3( Head of the Department ).
1. Dept. of Medical Radiation Physics, Kreis-krankenhaus Gummersbach Teaching Hospital of the University of Cologne, 51643 Gummersbach, Germany. 2. Dept. of Medical Physics and Biomedical Engineering, GonoBishwabidyalay (Gono University), Nayarhat, Savar, Dhaka- 1344, Bangladesh. 3. Department of Orthopedic and Traumatology, ShaheedSuhrawardy Medical College Hospital, Dhaka-1207,Bangladesh.
Contents:
Introduction:
Optimizing the results of fracture treatment requires a holistic view of both patients and treatment. There is a perception, not least among fracture surgeons themselves, that the mechanical issues have been over-emphasized in the past.
Introduction:
The principles of AO treatment, drummed into a generation of orthopedic trainees, were anatomical open reduction, rigid internal fixation and early rehabilitation of soft tissues without external splint.
Introduction: Now the science is taking another step, further in the direction from mechanics to biology. If the mechanical environment influences bone regeneration and hence fracture healing, how, at a cellular level, does it do so.
Introduction: Low level laser acts on biological tissues on cellular level. The basic premise is that LLLT stimulates cell activation processes which in turn, intensify physiologic al activities.
Introduction:
Low Level Laser increases Cellular ion-exchange, Tissue vascularization, Lymphatic circulation, Activates cytokines, Growth factors and necessary hormonal activities for tissue healing enhancement in the proliferative stage thereby reduction of pain & inflammation.
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Introduction:
And increases Fibroblast, Chondrocyte and osteoblast proliferation, Inhibition of osteoclast & Synthesis of bone collagen and bone matrix that activities & enhances bone regeneration.
Although there are no magical ways to fix a bone fracture, but there are ways to help speed up the healing process, and help fracture to heal properly/ faster.
Proper medical management. Nutritional Support. BMP/ Osteoblast cell injection Electrical stimulation. Magnetic stimulation. Ultrasound therapy. Gene-therapy Low Level Laser therapy.
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Laser mechanism on biological tissues can be explained by1. Physical mechanism 2. Bio-chemical mechanism
The primary (physical) mechanisms relate to the interaction between photons and molecules in the tissue, while the secondary mechanisms relate to the effect of the chemical (Bio-chemical) changes induced by primary effects.
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physicalThere are two primary forms of physical effects generated by laser irradiation on biological tissues: Photon-absorption (the basis of photobiological action, and generated by all forms of light). Internal conversion & fluorescence of light also generates Speckle formation, which is unique to laser therapy.
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Mechanism of action of LLLT on tissue (cont.): BiochemicalBio-chemical action of laser can be explained by Action of photon with mitochondrial respiratory chain- Cytochromecoxidase enzyme. Cytochromecoxidase mediated increase in ATP production. Cytochromecoxidase mediated singlet-oxygen production. Cytochromecoxidase mediated Reactive oxygen species (ROS) formation. Cytochromecoxidase mediated Photodiassociation and Nitric Oxide Production.
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Infrared laser radiation enhances bone regeneration/ formation by two consecutive phases of cellular, intra cellular and tissue modulating cascades of interdepended process. 1.Directly by simulation of osteoblast formation, inhibition of osteoclast activities, proliferation/differentiation of fibroblast and enhancement bone growth factors/ modulation of cytokines. 2. Indirectly by enhancing some specific bone formation modulation, and creating a friendly environment that fascinates bone formation /regeneration.
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Mechanism of action of Laser on Bone union(Direct) Studies of bone healing response to infrared light show acceleration of osteoblast formation as well as calcium salt deposition under the influence of infrared light. Osteoclast Inhibition Prevents Bone Mineral Resorption . Bone-matrix & collagen synthesis.
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Mechanism of action of Laser on Bone union(Indirect) Laser promotes cellular/tissue ion exchange / transport and enhances Bone Mineralization. Laser therapy increases Nitric Oxide in tissues which increases vascularity, thereby helps in tissue healing and Bone Formation. Laser therapy increases lymphatic circulation in bone and enhances better tissue healing & regeneration.
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Effects Of Low Level Laser (Ga-al-as, 830nm) On Human Appendicular Bone Fracture By Assessing Parameters: Objective (Clinical) & Subjective (Radiological).
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Duration of study: The duration of this study was two years (from April2008 to March- 2010). Type of study: Prospective Randomized Case Control study. Place of study: The study was conducted at ShaheedSuhrawardy Medical College Hospital in the Department of Orthopedics and Traumatology, SherE-Bangla Nagor, Dhaka-1207, Bangladesh.
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Materials & Method(Cont.) Method (Cont.) The patients were analyzed byClinical Assessment Pain & inflammation level. Stability of fracture side. Movement of fracture side. Immobilization duration. 26 Patient compliance.
Radiological Assessment Radiographic Scoring System (by Lane and Sandhu) of fracture site, done weekly. Densitometer assessment of Callus in the radiograph of fracture site, taken weekly.
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Clinically the laser group showed better stable fracture site, earlier movement of limb and removal of cast/plaster was performed. Pain & inflammation also subsided much earlier in the laser group (L1 & L2) than the control group (C1 & C2).
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Patient on LLLT
Before starting of treatment. L1-2. Patient Name: Md DalilUddin Age: 95 Years Sex: Male Diagnosis: Fracture Lt. Humerus (Shaft) Study group: L1
At 1st week
At 2nd week
At 3rd week
At 4th week
At 6th week
At 12th week
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fracture site,Cortex
2.0033
1.7767
1.7567 1.43
1.0167 1.1667 1.0033 0.8333 0.87 0.8367 0.9267 0.5633 At the end of the 1st week At the end of the 2nd week
1.2267
1.8133 1.0167
1.14
0.9333
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At the end of the 3rd week At the end of the 4th week At the end of the 6th week
2.0267
1.2333 1.1667
0.9033
0.9033
0.8367
1.0967 0.5633
0.8967
1.0933
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At the end of the 1st week At the end of the 2nd week At the end of the 3rd week At the end of the 4th week At the end of the 6th week
The result of this study reveals a better bone healing after irradiation with 830nm diode laser (Ga-Al-As). This study result also concludes that better bone healing after irradiation with Ga-Al-As, 830nm diode laser in human model as an adjunctive to regular fracture management that accelerates bone union significantly and enhances patient compliances.
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This study has demonstrated the potential of low level laser therapy in the treatment of Enhancement Of Human Bone Fracture Union.
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Future Recommendations(Cont.)
A large multi- centric study pointing important subjective (i.e. mechanical, biochemical and Histological , as well as objective (clinical) parameters.
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