Preparation No.

12
Calcium Hydroxide Topical Solution PROCEDURE:
Official, External, USP 31 1. Slake CaO for 5 mins.
(place in mortar or evaporating dish,
Formula sprinkle with 3-5 gtts of water, cover
Ingredients OA CA with watch glass. Let it stand for 5
CaOH 3g 0.09g mins.)
Water, qs ad 1000mL 30mL
2. Add 30 mL cold water
3. Agitate for 30 mins in an ice bath
Slaking
4. Filter, collect filtrate
CaO + 5gtts H2O -> Ca(OH)2
5. Transfer in container (liniment bottle)
56g/mol 74 g/mol

X:56g/n :: 0.09g:74g/n 6. Add cold water up to the brim

X= 0.07 g of CaO
**there should be no bubbles in bottle because
it indicates presence of carbon dioxide.

STIR FOR 15 mins. Ca(OH)2 + CO2  CaCO3 (white ppt)

WHY??
USES:
--to increase the solubility of CaOH in water
 Astringent
**avoid too much exposure to air
 Protective
AVOID BUBBLES??
Hydrogen + O2
Calcium hydroxide is less soluble in hot water
we were preventing the formation of CaCO3
than cold so cold purified water is the solvent.
(white precipitate)
SYNONYMS:
 lime water
FINAL RESULT:
 Liquor calcis
Clear solution, no bubbles inside your bottle.
CONTAINER && STORAGE:
Add enough cold water up the brim of the
Soln should be stored in well-filled, tightly
container.
stappered containers to deter the absorption of
CO2 & should be kept in a cool place to
maintain an adequate concentration of
dissolved solute, white clear solution.
Preparation no 13
Strong Iodine Solution USES:
Official, external, USP 31  Antiseptic
 Disinfectant
FORMULA Solubilizing agent
Ingredients OA CA - Converts iodine to triiodocomplex form
Iodine 50g 1.5g
which is more water soluble
KI 100g 3g=3mL
Water, qs ad 1000mL 30mL PHYSICAL APPEARANCE:
Like Betadine.
PROCEDURE
1. Dissolve KI in 2.5 mL of p.H2O
2. Dissolve Iodine crystals in KI soln
3. Add sufficient amt of H2O to obtain
15mL.

SYNONYMS:
 Lugol’s solution

METHOD OF PREPN:
 Simple solution Method
Potassium Iodide or sodium iodide
- Used as solubilizing agent for iodine

PRECAUTION:
1. Do not use stainless spatula bec iodine
is very corrosive & reactive, use the
porcelain instead.
2. Watch glass should be used in weighing
3. Avoid holding the iodine crystals bec it
would stain your hands & jewelries.
Solubility of 1g of I2 will be dissolved in 2950 mL
H2O ; it is very slightly soluble.
Preparation no 14 It should be stored in a cool place, preferably
Magnesium Citrate Oral Solution refrigerator. Keep the bottle on its side so the
Official, Internal, USP 31 cork or rubber liner of the cap is kept moist &
swollen, thereby maintaining the air tight seal
FORMULA between the cap & the bottle.
Ingredients OA CA
MgCO3 15 g 2.14 g
Magnesium Citrate Oral Solution is a colorless
Anhydrous 27.4 g 3.91 g
to slightly yellow, clear, effervescent liquid
Citric Acid
Syrup 60 mL 8.57 mL having a sweet, acidulous taste, a lemon flavor.
Talc 5g 0.71 g It is commonly referred to as citrate or ascapate
Lemon Oil 0.1 mL 0.01 mL
KHCO3 2.5 g 0.36 g of magnesia.
p.H2O qs ad 350 mL 50mL

Cotton – for the exchange of gas

EXPECTED RESULT: POP!

PROCEDURES:
Flavoring and sweetening agent
***Refer to your notes. 
 Lemon Oil and Syrup
Aluminum Foil
- Is used to avoid formation of molds
Talc
- Dispersing agent for lemon oil
- Clarifying agent w/c will remove
impurities

USES:
 Saline Cathartic

HEAT
 To allow reaction to take place
 Prevent the formation of molds
STORAGE:
Preparation no 15 SAPONIFICATION
Saponated Cresol Solution Conjugation process
Official, External, Poison Hydrolysis of ester by an alkaloid

FORMULA *Upon addition of cresol, it will bcome clear,

Ingredients OA CA yellow solution after stir.
Cresol 500mL 15mL
Vegetable Oil 350mL 10.5mL
Potassium OH 73 g 2.19 g METHOD OF PREPN
Alcohol 55mL 1.65 mL  Chemical or Simple
P.H2O, qs ad 1000mL 30mL

**Use hot plate with temperature not more

than 90c

Saponification process
Is complete  if the solution is clear; formation
of bubbles, no oil globules
Is incomplete has globules

TO CONFIRM:
**Test mixture using 1mL water + 1 drop of
mixture

Cresol
- Poisonous
- Immiscible in water(soap to dissolve)
- Responsible for disinfecting
- Caustic like phenol, can burn skin
*wash with alcohol or ethanol if put in skin
KOH – saponifying agent
Ester – vegetable oil (fatty acid)