LIVER CIRRHOSIS PATHOPHYSIOLOGY

chronic alcoholism

toxins from alcohol:

release of acetyldehyde
↑ AST, ALT,
damage hepatocytes
alkaline,
phophatase, GGT
necrosis of hepatocytes

fibrosis obstruction in
blood flow

↓ liver function liver cells regenerate PORTAL

in abnormal pattern HYPERTENSION

liver cells loaded with fat

enlargement

irritates the Glisson capsule

PAIN

↑ glycogenesis ↓ production ↓ CHON ↓ production ↓ metabolism of ↓ metabolism ↓ stores of vitamins obstruction of bile flow
↓ glycogenolysis, of albumin synthesis of clotting ammonia drugs and minerals
glucogenesis (in factors
↓ colloidal general) drug toxicity ↓ fat ↓ bilirubin bile reabsorbed in
↑ ammonia
altered glucose osmotic altered clotting absorption in GIT the blood
levels
metabolism pressure altered studies ↓ RBC ↓ energy ↓ energy
immune production production ↓ Vitamin K bilirubin in
↓ energy bleeding hepatic production
edema, function absorption feces bile salts in jaundice ↑ bile in
tendendcies encephalopathy
ascites and altered skin kidney
anemia ↓ energy
healing ↓ clotting clay-colored
blood loss feces pruritus production
factors dark-colored
changes in coma
susceptibility urine
anemia coordination,
to infection bleeding/
memory, death
anemia ↑ bilirubin level
↓ metabolism of steroid hormone orientation

asterixis, fetor
estrogen, progesterone, aldosterone hepaticus
testosterone

Na and water ↑ K+ and H+

male female retention excretion

loss of male loss of feminine edema, ascites alkalosis

characteristics characteristics
and and hypokalemia
development of development of
some feminine some male
characteristics characteristics