Change in one base-pair in DNA molecule

Valine produced instead of glutamic acid

at position, 6 in B-chain

Abnormal Hgb Molecule

Sickling of RBC Concentration of

Destruction of sickle- shaped cells in
many sickle the spleen
cells
Clumping of sickle shaped cells interfere
with circulation
Enlargement
of spleen
Anemia
Impaired blood supply to
various organs
Fibrosis of
spleen
Enlargement
Proliferation of of heart
bone marrow
Slowed Damage to Brain Kidney
Damage to Damage to Damage to
Weakness & physical heart damage damage
lungs muscles abd organs
lassitude developme muscle and joints

Impaired
mental Renal
Heart Failure Pneumonia Rheumatism Paralysis Abd pain
function Failure

DEATH