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Pharos University
DIAGNOSTIC AGENTS
Used either to demonstrate Abnormalities in
structure or Impairment of functions of body organs.
The most widely used methods for non-invasive
imaging are:
(without exploratory surgery)
Terminology
Radiographic Procedure Tissue (Organ) Visualized
1 Angiography Blood vessels
2 Cholecystography Gall bladder
3 Cholangiography Gall bladder and Bile ducts
4 Hepatography Liver
5 Urography Urinary tract
6 Bronchography Lungs
7 Lymphography Lymph nodes and vessels
8 Esophago graphy Esophagus
9 Histero salpin gography Uterus and fallopian tubes
Spinal cord & subarachiniod
10 Myelography
spaces
Classification of
Agents used as X-
X-ray contrast media
1. Agents Used To Outline the Gall Bladder and Bile Ducts
I
1. lopanoic Acid (Telepaque) H2N
C2H5
COOH
NH2
I I
CH3 Normal cholecystogram
H3C N the contrast medium is seen
COOH
evenly filling the gallbladder
O
3-[Acetyl(3-amino-2,4,6-triiodophenyl)amino]-
2-methyl-propionic acid.
N.B:
B. Cholagiographic Agents
o They are moderately strong dibasic tri-iodobenzoic
acid dimers linked by a polymethylene chain of
variable length.
image showing the biliary tree and the main pancreatic duct
5-Acetamido-2,4,6-triiodo-N-methyl-isophthalamic acid
These are used in:
Intravascular angiography
Aortography
Selective renal arteriography
Urography
COOH
ii. Diatrizoic Acid Gastrografin I I
O O
H3C N N CH3
H H
I
3,5-Diacetamido-2,4,6-triiodobenzoicacid
I I
CH3 I I
CH3
H3C N H3C N
COOH COOH
O O
I I
OH
H
It provides improved image N OH
HO N
details with low risk of OH I O
toxicity. COCH3
5-[N-(2,3-Dihydroxypropylacetamido)]-
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-
benzene-1,3-dicarboxamide
Propyliodone (Dinosil)
Propyl 2-(3,5-diiodo-4-oxo-1,4-
dihydropyridin-1-yl)acetate
H2 NCH2COOH Reduction
Pyridine Zn/HCl
NO 2 NO 2 NH2
I132
N-(2-lodobenzoyl)glycine sodium salt
Performance of kidneys can be
determined by injecting a radioactive
compound which can be quickly and exclusively excreted
by kidneys
Renal malfunction can be indicated when the measured
activities in the two kidneys are unequal
iii. Inulin
It is present in the form of 10% inulin and 0.8% NaCI injection
It is used to evaluate the glomerular filtration
rate (GFR) because it is filtered by the glomeruli,
excreted unchanged and not reabsorbed by
the tubules.
HO
It is obtained commercially by OH
OH OH
the catalytic reduction of glucose.
It is used to as diagnostic agent for kidney function and also
as osmotic diuretic.
3,3’-disulfonate Br
Br OH
It is the best agent used to test for
liver function. SO3 Na
HO
It is administered IV…. 30 min after,
blood sample ….. The dye content in the alkalinized
serum is measured. Normal liver can remove most of the
amount of the injected dye within 30 min.
Assay of Sulfobromophthalein OH
ORGAN
IMAGING
2,4,6-TRIIODO
PH.ALKANOIC
DIMER 3,5-SUBS
BENZOIC
IOPANOIC DIATRIZOIC
LIPOIDOL
ACID ACID
ORGAN
FUNCTIONING
RENAL LIVER STOMACH
IODOHIPPURATE OSMOTIC-
TUBULAR
DIAGNOSTIC
CAPACITY
INULIN
MANNITOL GLOMERULAR
MALFUNCT FILTERATION
ION